Parkin mediates neuroprotection through activation of IkappaB kinase/nuclear factor-kappaB signaling (Q24297849)

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• Parkin Mediates Neuroprotection through Activation of I B Kinase/Nuclear Factor- B Signaling

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English	Parkin mediates neuroprotection through activation of IkappaB kinase/nuclear factor-kappaB signaling	scientific article	Parkin Mediates Neuroprotection through Activation of I B Kinase/Nuclear Factor- B Signaling

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6673568

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26 December 2019

title

Parkin mediates neuroprotection through activation of IkappaB kinase/nuclear factor-kappaB signaling (English)

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6673568

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26 December 2019

author

Carsten Culmsee

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8

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6673568

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26 December 2019

Daniel Krappmann

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10

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6673568

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26 December 2019

Jorg Tatzelt

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11

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6673568

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26 December 2019

Konstanze Winklhofer

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12

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6673568

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26 December 2019

Benedikt Berninger

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9

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Benedikt Berninger

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6673568

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26 December 2019

author name string

Iris H Henn

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1

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6673568

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26 December 2019

Lena Bouman

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2

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6673568

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26 December 2019

Julia S Schlehe

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3

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6673568

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26 December 2019

Anita Schlierf

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4

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6673568

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26 December 2019

Julia E Schramm

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5

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6673568

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26 December 2019

Elmar Wegener

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6

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6673568

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26 December 2019

Kazuhiro Nakaso

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7

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PMC publication ID

6673568

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17314283%20AND%20SRC:MED&resulttype=core&format=json

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26 December 2019

language of work or name

English

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publication date

1 February 2007

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Europe PubMed Central

PMC publication ID

6673568

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17314283%20AND%20SRC:MED&resulttype=core&format=json

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26 December 2019

published in

Journal of Neuroscience

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Europe PubMed Central

PMC publication ID

6673568

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26 December 2019

volume

27

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Europe PubMed Central

PMC publication ID

6673568

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17314283%20AND%20SRC:MED&resulttype=core&format=json

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26 December 2019

issue

8

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Europe PubMed Central

PMC publication ID

6673568

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17314283%20AND%20SRC:MED&resulttype=core&format=json

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26 December 2019

page(s)

1868-1878

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Europe PubMed Central

PMC publication ID

6673568

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26 December 2019

cites work

Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17314283

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunohistochemical and subcellular localization of Parkin protein: absence of protein in autosomal recessive juvenile parkinsonism patients

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17314283

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Roles of nuclear factor kappaB in neuronal survival and plasticity

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17314283

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The I kappa B kinase (IKK) complex is tripartite and contains IKK gamma but not IKAP as a regular component.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17314283

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17314283

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17314283

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

B-cell receptor- and phorbol ester-induced NF-kappaB and c-Jun N-terminal kinase activation in B cells requires novel protein kinase C's

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17314283

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Geldanamycin restores a defective heat shock response in vivo

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17314283

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NF-kappaB at the crossroads of life and death

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17314283

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17314283

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17314283

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17314283

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tetrameric oligomerization of IkappaB kinase gamma (IKKgamma) is obligatory for IKK complex activity and NF-kappaB activation

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17314283

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17314283

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17314283

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New parkin mutations and atypical phenotypes in families with autosomal recessive parkinsonism

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17314283

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel monoclonal antibodies demonstrate biochemical variation of brain parkin with age.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17314283

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inactivation of parkin by oxidative stress and C-terminal truncations: a protective role of molecular chaperones

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17314283

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Parkin is recruited into aggresomes in a stress-specific manner: over-expression of parkin reduces aggresome formation but can be dissociated from parkin's effect on neuronal survival

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17314283

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetics of parkin-linked disease.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17314283

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17314283

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Parkin genetics: one model for Parkinson's disease

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17314283

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Parkin counteracts symptoms in a Drosophila model of Parkinson's disease

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17314283

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Parkin attenuates manganese-induced dopaminergic cell death

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17314283

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Parkin protects human dopaminergic neuroblastoma cells against dopamine-induced apoptosis

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17314283

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signaling to NF-kappaB

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17314283

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NF-kappaB signaling: flipping the switch with polyubiquitin chains

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17314283

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polyubiquitin chains: polymeric protein signals

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17314283

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Parkin phosphorylation and modulation of its E3 ubiquitin ligase activity

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17314283

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an alpha-synuclein rat model of Parkinson's disease

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17314283

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathogenic mutations inactivate parkin by distinct mechanisms.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17314283

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha-synuclein and parkin contribute to the assembly of ubiquitin lysine 63-linked multiubiquitin chains

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17314283

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A pervasive role of ubiquitin conjugation in activation and termination of IkappaB kinase pathways

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17314283

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signaling via NF-kappaB in the nervous system

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17314283

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Familial-associated mutations differentially disrupt the solubility, localization, binding and ubiquitination properties of parkin.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17314283

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ubiquitin signalling in the NF-kappaB pathway

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17314283

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distinct regulation of Ubc13 functions by the two ubiquitin-conjugating enzyme variants Mms2 and Uev1A

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17314283

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ubiquitylation and cell signaling

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17314283

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dopamine covalently modifies and functionally inactivates parkin

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17314283

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired transcriptional upregulation of Parkin promoter variant under oxidative stress and proteasomal inhibition: clinical association

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17314283

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stress-induced alterations in parkin solubility promote parkin aggregation and compromise parkin's protective function

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17314283

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diverse effects of pathogenic mutations of Parkin that catalyze multiple monoubiquitylation in vitro

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17314283

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection of compound heterozygous deletions in the parkin gene of fibroblasts in patients with autosomal recessive hereditary parkinsonism (PARK2).

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17314283

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Parkin protects against mitochondrial toxins and beta-amyloid accumulation in skeletal muscle cells

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17314283

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17314283

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17314283

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Different mechanisms control signal-induced degradation and basal turnover of the NF-kappaB inhibitor IkappaB alpha in vivo

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17314283

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17314283

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

DOI

10.1523/JNEUROSCI.5537-06.2007

2 references

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

4370910

stated in

Europe PubMed Central

PMC publication ID

6673568

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17314283%20AND%20SRC:MED&resulttype=core&format=json

retrieved

26 December 2019

OpenCitations bibliographic resource ID

4370910

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

4370910

PMC publication ID

6673568

1 reference

stated in

Europe PubMed Central

PMC publication ID

6673568

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17314283%20AND%20SRC:MED&resulttype=core&format=json

retrieved

26 December 2019

PubMed publication ID

17314283

2 references

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

4370910

stated in

Europe PubMed Central

PMC publication ID

6673568

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17314283%20AND%20SRC:MED&resulttype=core&format=json

retrieved

26 December 2019

 

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