Tumor suppressor LATS1 is a negative regulator of oncogene YAP (Q24304725)

GOA release 2020-03-11

hippo signaling

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GOA release 2020-03-11

author name string

Yawei Hao

1

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Alex Chun

2

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Kevin Cheung

3

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Babak Rashidi

4

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Xiaolong Yang

Journal of Biological Chemistry

5

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language of work or name

English

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publication date

29 February 2008

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published in

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volume

283

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issue

9

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page(s)

5496-509

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Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts

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Negative regulators of cyclin-dependent kinases and their roles in cancers

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Control of cell proliferation and apoptosis by mob as tumor suppressor, mats

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The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP

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Elucidation of a universal size-control mechanism in Drosophila and mammals

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The tumor-suppressor gene fat controls tissue growth upstream of expanded in the hippo signaling pathway.

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Direct induction of autophagy by Atg1 inhibits cell growth and induces apoptotic cell death

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The Drosophila RASSF homolog antagonizes the hippo pathway

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Cellular signaling by fibroblast growth factor receptors

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Platelet-derived growth factor receptor (PDGFR): a target for anticancer therapeutics.

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Phosphorylation of human microtubule-associated protein tau by protein kinases of the AGC subfamily

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Centrosome-associated NDR kinase regulates centrosome duplication

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Shedding light on Merlin's wizardry

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Putative tumor suppressor Lats2 induces apoptosis through downregulation of Bcl-2 and Bcl-x(L).

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salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines

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Integrins: bidirectional, allosteric signaling machines

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hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts

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The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis

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Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis

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Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity

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Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction

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Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway

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LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1

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The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis

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Delineation of a Fat tumor suppressor pathway

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The Salvador-Warts-Hippo pathway - an emerging tumour-suppressor network

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Mechanisms of specificity in protein phosphorylation

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Filling out the Hippo pathway

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Tyrosine phosphorylation controls Runx2-mediated subnuclear targeting of YAP to repress transcription

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Human BAG-1/RAP46 protein is generated as four isoforms by alternative translation initiation and overexpressed in cancer cells

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Human homologue of Drosophila lats, LATS1, negatively regulate growth by inducing G(2)/M arrest or apoptosis.

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Lats2, a putative tumor suppressor, inhibits G1/S transition

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The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1

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Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon

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Yes-associated protein and p53-binding protein-2 interact through their WW and SH3 domains

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Physical interaction with Yes-associated protein enhances p73 transcriptional activity

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Inhibition of cell growth by conditional expression of kpm, a human homologue of Drosophila warts/lats tumor suppressor

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A WW domain-containing yes-associated protein (YAP) is a novel transcriptional co-activator

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Hippo signaling in organ size control

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Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control

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TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm

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The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation

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WW domains provide a platform for the assembly of multiprotein networks

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RASSF4/AD037 is a potential ras effector/tumor suppressor of the RASSF family.

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Beta4 integrin is a transforming molecule that unleashes Met tyrosine kinase tumorigenesis

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Identifiers

DOI

10.1074/JBC.M709037200

1 reference

Consolidated OpenCitations Corpus – April 2017

release_omlgwxm5vrdqvomjb54zmifmqe

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/omlgwxm5vrdqvomjb54zmifmqe

24 November 2022

mapped directly with Wikidata item

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

18158288

1 reference

Consolidated OpenCitations Corpus – April 2017