Mechanisms of specificity in protein phosphorylation (Q29617541)

Europe PubMed Central

title

Mechanisms of specificity in protein phosphorylation (English)

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30 April 2017

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Ubersax JA

1

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30 April 2017

Ferrell JE Jr

series ordinal

2

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=17585314

30 April 2017

language of work or name

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30 April 2017

publication date

July 2007

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Nature Reviews Molecular Cell Biology

30 April 2017

published in

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30 April 2017

volume

8

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30 April 2017

issue

7

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30 April 2017

page(s)

530-41

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The protein kinase complement of the human genome

30 April 2017

cites work

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Evolution of protein kinase signaling from yeast to man

31 March 2020

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The mouse kinome: discovery and comparative genomics of all mouse protein kinases

31 March 2020

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Analysis of yeast protein kinases using protein chips.

31 March 2020

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How do protein kinases recognize their substrates?

31 March 2020

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The regulation of protein function by multisite phosphorylation--a 25 year update

31 March 2020

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Comprehensive analysis of amino acid and nucleotide composition in eukaryotic genomes, comparing genes and pseudogenes

31 March 2020

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Global analysis of protein phosphorylation in yeast

31 March 2020

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Targets of the cyclin-dependent kinase Cdk1

31 March 2020

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The protein kinase family: conserved features and deduced phylogeny of the catalytic domains

31 March 2020

1 reference

Crystal Structure of the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase

31 March 2020

1 reference

2.0 A refined crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with a peptide inhibitor and detergent

31 March 2020

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Crystal structure of cyclin-dependent kinase 2

31 March 2020

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Atomic structure of the MAP kinase ERK2 at 2.3 A resolution

31 March 2020

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Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex

31 March 2020

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Three-dimensional structure of the tyrosine kinase c-Src

31 March 2020

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The crystal structure of a phosphorylase kinase peptide substrate complex: kinase substrate recognition

31 March 2020

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Targeting of PKA, PKC and protein phosphatases to cellular microdomains

31 March 2020

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Docking domains and substrate-specificity determination for MAP kinases

31 March 2020

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Kinetic and catalytic mechanisms of protein kinases

31 March 2020

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Signalling specificity of Ser/Thr protein kinases through docking-site-mediated interactions

31 March 2020

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Domains, motifs, and scaffolds: the role of modular interactions in the evolution and wiring of cell signaling circuits.

31 March 2020

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Docking interactions in protein kinase and phosphatase networks

31 March 2020

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Networks for the allosteric control of protein kinases

31 March 2020

1 reference

Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog

31 March 2020

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The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases

31 March 2020

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Structural basis for phosphotyrosine peptide recognition by protein tyrosine phosphatase 1B

31 March 2020

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Structural basis for substrate specificity of protein-tyrosine phosphatase SHP-1

31 March 2020

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Structural and evolutionary relationships among protein tyrosine phosphatase domains

31 March 2020

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Substrate specificity of the cyclic AMP-dependent protein kinase

31 March 2020

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Synthetic substrate for cyclic AMP-dependent protein kinase

31 March 2020

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Protein kinase phosphorylation site sequences and consensus specificity motifs: tabulations

31 March 2020

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Use of an oriented peptide library to determine the optimal substrates of protein kinases

31 March 2020

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A rapid method for determining protein kinase phosphorylation specificity

31 March 2020

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Global, in vivo, and site-specific phosphorylation dynamics in signaling networks

31 March 2020

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A motif-based profile scanning approach for genome-wide prediction of signaling pathways

31 March 2020

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The role of Thr160 phosphorylation of Cdk2 in substrate recognition

31 March 2020

1 reference

2.2 A refined crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MnATP and a peptide inhibitor

31 March 2020

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Dynamics of signaling by PKA.

31 March 2020

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Protein modification: docking sites for kinases

31 March 2020

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JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation

31 March 2020

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Signaling in the yeast pheromone response pathway: specific and high-affinity interaction of the mitogen-activated protein (MAP) kinases Kss1 and Fus3 with the upstream MAP kinase kinase Ste7.

31 March 2020

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A conserved motif at the amino termini of MEKs might mediate high-affinity interaction with the cognate MAPKs

31 March 2020

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Phosphorylated seryl and threonyl, but not tyrosyl, residues are efficient specificity determinants for GSK-3beta and Shaggy.

31 March 2020

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Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA

31 March 2020

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Identification of a cyclin-cdk2 recognition motif present in substrates and p21-like cyclin-dependent kinase inhibitors

31 March 2020

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Substrate recruitment to cyclin-dependent kinase 2 by a multipurpose docking site on cyclin A.

31 March 2020

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Determinants of specificity in TGF-beta signal transduction.

31 March 2020

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The L3 loop: a structural motif determining specific interactions between SMAD proteins and TGF-beta receptors.

31 March 2020

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A conserved docking motif in MAP kinases common to substrates, activators and regulators

31 March 2020

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Transcription factor ATF2 regulation by the JNK signal transduction pathway

31 March 2020

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ATF-2 contains a phosphorylation-dependent transcriptional activation domain

31 March 2020

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The Elk-1 ETS-domain transcription factor contains a mitogen-activated protein kinase targeting motif.

31 March 2020

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Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors

31 March 2020

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Docking motif interactions in MAP kinases revealed by hydrogen exchange mass spectrometry

31 March 2020

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The role of docking interactions in mediating signaling input, output, and discrimination in the yeast MAPK network

31 March 2020

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ERK2 mitogen-activated protein kinase binding, phosphorylation, and regulation of the PDE4D cAMP-specific phosphodiesterases. The involvement of COOH-terminal docking sites and NH2-terminal UCR regions

31 March 2020

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Spatially separate docking sites on ERK2 regulate distinct signaling events in vivo

31 March 2020

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Protein tyrosine kinase structure and function

31 March 2020

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Multisite phosphorylation and the countdown to S phase

31 March 2020

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Crystal structures of MAP kinase p38 complexed to the docking sites on its nuclear substrate MEF2A and activator MKK3b

31 March 2020

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Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125.

31 March 2020

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The role of the phospho-CDK2/cyclin A recruitment site in substrate recognition.

31 March 2020

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Two-faced cyclins with eyes on the targets

31 March 2020

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Specialization and targeting of B-type cyclins

31 March 2020

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Interaction of the S-phase cyclin Clb5 with an "RXL" docking sequence in the initiator protein Orc6 provides an origin-localized replication control switch.

31 March 2020

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A bipartite substrate recognition motif for cyclin-dependent kinases

31 March 2020

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Crystal structure of the human cell cycle protein CksHs1: single domain fold with similarity to kinase N-lobe domain

31 March 2020

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Crystal structure and mutational analysis of the human CDK2 kinase complex with cell cycle-regulatory protein CksHs1

31 March 2020

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Xe-p9, a Xenopus Suc1/Cks protein, is essential for the Cdc2-dependent phosphorylation of the anaphase- promoting complex at mitosis

31 March 2020

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The Cdk-associated protein Cks1 functions both in G1 and G2 in Saccharomyces cerevisiae

31 March 2020

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Proteomic screen finds pSer/pThr-binding domain localizing Plk1 to mitotic substrates

31 March 2020

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The molecular basis for phosphodependent substrate targeting and regulation of Plks by the Polo-box domain

31 March 2020

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Crystal structure of glycogen synthase kinase 3 beta: structural basis for phosphate-primed substrate specificity and autoinhibition

31 March 2020

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A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation

31 March 2020

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Structure of GSK3beta reveals a primed phosphorylation mechanism

31 March 2020

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A phosphoserine-regulated docking site in the protein kinase RSK2 that recruits and activates PDK1.

31 March 2020

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High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site

31 March 2020

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Translocation of cyclin B1 to the nucleus at prophase requires a phosphorylation-dependent nuclear import signal

31 March 2020

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Active cyclin B1-Cdk1 first appears on centrosomes in prophase

31 March 2020

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The localization of human cyclins B1 and B2 determines CDK1 substrate specificity and neither enzyme requires MEK to disassemble the Golgi apparatus

31 March 2020

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Unmasking the S-Phase-Promoting Potential of Cyclin B1

31 March 2020

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Distinct subcellular localization patterns contribute to functional specificity of the Cln2 and Cln3 cyclins of Saccharomyces cerevisiae

31 March 2020

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Signaling pathways for PC12 cell differentiation: making the right connections

31 March 2020

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A constitutively active and nuclear form of the MAP kinase ERK2 is sufficient for neurite outgrowth and cell transformation

31 March 2020

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Localization of protein kinase C isozymes in cardiac myocytes

31 March 2020

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Identification of intracellular receptor proteins for activated protein kinase C

31 March 2020

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AKAP signalling complexes: focal points in space and time

31 March 2020

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Spatial gradients of cellular phospho-proteins

31 March 2020

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Signaling through scaffold, anchoring, and adaptor proteins

31 March 2020

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MAP kinase dynamics in response to pheromones in budding yeast

31 March 2020

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Principles of MAP kinase signaling specificity in Saccharomyces cerevisiae.

31 March 2020

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Rewiring MAP kinase pathways using alternative scaffold assembly mechanisms

31 March 2020

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Redirecting tyrosine kinase signaling to an apoptotic caspase pathway through chimeric adaptor proteins

31 March 2020

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The biological functions of A-kinase anchor proteins.

31 March 2020

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PDZ-containing proteins: alternative splicing as a source of functional diversity

31 March 2020

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Identification of B-KSR1, a novel brain-specific isoform of KSR1 that functions in neuronal signaling

31 March 2020

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The Ste5 scaffold allosterically modulates signaling output of the yeast mating pathway.

31 March 2020

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Association of protein kinase A and protein phosphatase 2B with a common anchoring protein

31 March 2020

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Coordination of three signaling enzymes by AKAP79, a mammalian scaffold protein

31 March 2020

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mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module

31 March 2020

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A mammalian scaffold complex that selectively mediates MAP kinase activation

31 March 2020

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The JIP group of mitogen-activated protein kinase scaffold proteins

31 March 2020

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The JNK-interacting protein-1 scaffold protein targets MAPK phosphatase-7 to dephosphorylate JNK.

31 March 2020

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Dynamic interaction between the dual specificity phosphatase MKP7 and the JNK3 scaffold protein beta-arrestin 2.

31 March 2020

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Cyclin specificity in the phosphorylation of cyclin-dependent kinase substrates.

31 March 2020

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Substrate competition as a source of ultrasensitivity in the inactivation of Wee1.

31 March 2020

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Kinetic Proofreading: A New Mechanism for Reducing Errors in Biosynthetic Processes Requiring High Specificity

31 March 2020

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The role of proofreading in signal transduction specificity

31 March 2020

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Mechanistic studies of the dual phosphorylation of mitogen-activated protein kinase

31 March 2020

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MAPK specificity in the yeast pheromone response independent of transcriptional activation.

31 March 2020

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Specificity of MAP kinase signaling in yeast differentiation involves transient versus sustained MAPK activation

31 March 2020

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Pheromone-dependent destruction of the Tec1 transcription factor is required for MAP kinase signaling specificity in yeast.

31 March 2020

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Fus3-regulated Tec1 degradation through SCFCdc4 determines MAPK signaling specificity during mating in yeast

31 March 2020

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Cross-talk and decision making in MAP kinase pathways

31 March 2020

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Phosphorylated synthetic peptides as tools for studying protein phosphatases

31 March 2020

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Transforming gene product of Rous sarcoma virus phosphorylates tyrosine

31 March 2020

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Protein tyrosine phosphatases in the human genome

31 March 2020

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Genetic analysis of the kinome and phosphatome in cancer

31 March 2020

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Emerging roles of nuclear protein phosphatases

31 March 2020

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The structure of the cell cycle protein Cdc14 reveals a proline-directed protein phosphatase

31 March 2020

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Crystal structures of c-Src reveal features of its autoinhibitory mechanism

31 March 2020

1 reference

A structural basis for substrate specificities of protein Ser/Thr kinases: primary sequence preference of casein kinases I and II, NIMA, phosphorylase kinase, calmodulin-dependent kinase II, CDK5, and Erk1.

31 March 2020

1 reference

One-thousand-and-one substrates of protein kinase CK2?

31 March 2020

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Engineering the substrate specificity of the Abl tyrosine kinase

31 March 2020

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Catalytic specificity of protein-tyrosine kinases is critical for selective signalling

31 March 2020

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Peptide and protein library screening defines optimal substrate motifs for AKT/PKB.

31 March 2020

1 reference

Characterization of the proto-oncogene pim-1: kinase activity and substrate recognition sequence

31 March 2020

1 reference

The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification 1

31 March 2020

1 reference

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