Protective effect against Parkinson's disease-related insults through the activation of XBP1 (Q24314837)

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author name string

Megumi Sado

1

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Yuki Yamasaki

2

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Tomoyuki Iwanaga

3

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Yasushi Onaka

4

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Tatsuki Ibuki

5

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Shigeki Nishihara

6

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Hiroshi Mizuguchi

7

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Hiroshi Momota

8

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Ryuichi Kishibuchi

9

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Tetsuya Hashimoto

10

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Daisuke Wada

11

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Hisashi Kitagawa

12

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Takeshi K Watanabe

Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's disease

13

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language of work or name

English

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publication date

27 February 2009

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published in

Brain Research

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volume

1257

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page(s)

16-24

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cites work

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Discordance of UPR signaling by ATF6 and Ire1p-XBP1 with levels of target transcripts

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Activation of the unfolded protein response in Parkinson's disease

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A kinase inhibitor activates the IRE1alpha RNase to confer cytoprotection against ER stress

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Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1

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XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

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Regulated translation initiation controls stress-induced gene expression in mammalian cells

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ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs

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Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

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IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

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Parkinsonian mimetics induce aspects of unfolded protein response in death of dopaminergic neurons

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Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response

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