Mammalian NDR/LATS protein kinases in hippo tumor suppressor signaling (Q24315808)

Serine/threonine kinase 4

Europe PubMed Central

title

Mammalian NDR/LATS protein kinases in hippo tumor suppressor signaling (English)

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main subject

clinical chemistry

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Serine/threonine kinase 3

GOA release 2020-03-11

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GOA release 2020-03-11

hippo signaling

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Mammalian NDR protein kinases: from regulation to a role in centrosome duplication.

GOA release 2020-03-11

2

Brian A Hemmings

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author name string

Alexander Hergovich

series ordinal

1

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language of work or name

English

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publication date

2009

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35

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issue

4

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page(s)

338-45

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cites work

1 reference

The neurofibromatosis 2 tumor suppressor gene product, merlin, regulates human meningioma cell growth by signaling through YAP

21 January 2018

1 reference

Frequent hypermethylation of MST1 and MST2 in soft tissue sarcoma

21 January 2018

1 reference

7 January 2021

Control of cell proliferation and apoptosis by mob as tumor suppressor, mats

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7 January 2021

Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach

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7 January 2021

Elucidation of a universal size-control mechanism in Drosophila and mammals

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7 January 2021

Large-scale mutagenesis in p19(ARF)- and p53-deficient mice identifies cancer genes and their collaborative networks

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7 January 2021

Biosignaling of mammalian Ste20-related kinases

1 reference

7 January 2021

RASSF1A is part of a complex similar to the Drosophila Hippo/Salvador/Lats tumor-suppressor network.

1 reference

7 January 2021

YAP1 increases organ size and expands undifferentiated progenitor cells

1 reference

7 January 2021

MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation

1 reference

7 January 2021

NDR kinase is activated by RASSF1A/MST1 in response to Fas receptor stimulation and promotes apoptosis

1 reference

7 January 2021

Expression of Yes-associated protein in common solid tumors

1 reference

7 January 2021

Centrosome-associated NDR kinase regulates centrosome duplication

1 reference

7 January 2021

RASSF1A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor protein

1 reference

7 January 2021

Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage

1 reference

7 January 2021

PML, YAP, and p73 are components of a proapoptotic autoregulatory feedback loop.

1 reference

7 January 2021

Nf2/merlin regulates hematopoietic stem cell behavior by altering microenvironmental architecture

1 reference

7 January 2021

Identification of genes associated with tumorigenesis of retinoblastoma by microarray analysis.

1 reference

7 January 2021

salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines

1 reference

7 January 2021

hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts

1 reference

7 January 2021

Crystal structure of a human Mob1 protein: toward understanding Mob-regulated cell cycle pathways

1 reference

7 January 2021

Men and sin: what's the difference?

1 reference

7 January 2021

Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity

1 reference

7 January 2021

Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction

1 reference

7 January 2021

A crucial role of WW45 in developing epithelial tissues in the mouse

1 reference

7 January 2021

Prognostic significance of mammalian sterile20-like kinase 1 in colorectal cancer.

1 reference

7 January 2021

The tumour suppressor Hippo acts with the NDR kinases in dendritic tiling and maintenance

1 reference

7 January 2021

TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal

1 reference

7 January 2021

Mutations in transcript isoforms of the neurofibromatosis 2 gene in multiple human tumour types

1 reference

7 January 2021

New genes involved in cancer identified by retroviral tagging

1 reference

7 January 2021

KLF4, p21 and context-dependent opposing forces in cancer

1 reference

7 January 2021

The Salvador-Warts-Hippo pathway - an emerging tumour-suppressor network

1 reference

7 January 2021

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

1 reference

7 January 2021

NDR kinases regulate essential cell processes from yeast to humans

1 reference

7 January 2021

Filling out the Hippo pathway

1 reference

7 January 2021

PI3K pathway alterations in cancer: variations on a theme

1 reference

7 January 2021

Threonine 74 of MOB1 is a putative key phosphorylation site by MST2 to form the scaffold to activate nuclear Dbf2-related kinase 1

1 reference

7 January 2021

Lats2/Kpm is required for embryonic development, proliferation control and genomic integrity

1 reference

7 January 2021

Mob as tumor suppressor is activated by Hippo kinase for growth inhibition in Drosophila

1 reference

7 January 2021

LATS1 tumor suppressor regulates G2/M transition and apoptosis

1 reference

7 January 2021

Lats2, a putative tumor suppressor, inhibits G1/S transition

1 reference

7 January 2021

The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1

1 reference

7 January 2021

Glomerulocystic kidney disease in mice with a targeted inactivation of Wwtr1

1 reference

7 January 2021

Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon

1 reference

7 January 2021

WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus

1 reference

7 January 2021

Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 protein

1 reference

7 January 2021

Lats2 is an essential mitotic regulator required for the coordination of cell division.

1 reference

7 January 2021

Tumor suppressor LATS1 is a negative regulator of oncogene YAP

1 reference

7 January 2021

Mst2 and Lats kinases regulate apoptotic function of Yes kinase-associated protein (YAP)

1 reference

7 January 2021

Contact-dependent inhibition of EGFR signaling by Nf2/Merlin

1 reference

7 January 2021

YAP1 is involved in mesothelioma development and negatively regulated by Merlin through phosphorylation

1 reference

7 January 2021

NF2deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions

1 reference

7 January 2021

The Nf2 tumor suppressor gene product is essential for extraembryonic development immediately prior to gastrulation

1 reference

7 January 2021

Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors

1 reference

7 January 2021

A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization

1 reference

7 January 2021

Hippo signaling in organ size control

1 reference

7 January 2021

Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control

1 reference

7 January 2021

"Stemness": transcriptional profiling of embryonic and adult stem cells

1 reference

7 January 2021

TAZ, a transcriptional modulator of mesenchymal stem cell differentiation

1 reference

7 January 2021

TAZ promotes PC2 degradation through a SCFbeta-Trcp E3 ligase complex

1 reference

7 January 2021

TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway

1 reference

7 January 2021

Regulation of NDR protein kinase by hydrophobic motif phosphorylation mediated by the mammalian Ste20-like kinase MST3

1 reference

7 January 2021

Defects in yolk sac vasculogenesis, chorioallantoic fusion, and embryonic axis elongation in mice with targeted disruption of Yap65

1 reference

7 January 2021

Multiple renal cysts, urinary concentration defects, and pulmonary emphysematous changes in mice lacking TAZ

1 reference

7 January 2021

Role of the tumor suppressor RASSF1A in Mst1-mediated apoptosis.

1 reference

7 January 2021

A role for TAZ in migration, invasion, and tumorigenesis of breast cancer cells

1 reference

7 January 2021

Negative regulation of YAP by LATS1 underscores evolutionary conservation of the Drosophila Hippo pathway

1 reference

7 January 2021

Merlin is a potent inhibitor of glioma growth

1 reference

7 January 2021

Kpm/Lats2 is linked to chemosensitivity of leukemic cells through the stabilization of p73.

1 reference

7 January 2021

The Fat and Warts signaling pathways: new insights into their regulation, mechanism and conservation

1 reference

7 January 2021