p53: 25 years after its discovery (Q24338379)

Trends in Pharmacological Sciences

Europe PubMed Central

title

p53: 25 years after its discovery (English)

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2

S Perwez Hussain

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author name string

Lorne J Hofseth

series ordinal

1

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Curtis C Harris

series ordinal

3

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language of work or name

English

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publication date

April 2004

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published in

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volume

25

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issue

4

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page(s)

177-81

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cites work

TP53 and breast cancer

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TP53 mutation in colorectal cancer

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Introduction: p53--the first twenty years

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Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

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The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

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Direct involvement of p53 in the base excision repair pathway of the DNA repair machinery

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p53, the cellular gatekeeper for growth and division

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Small molecules that reactivate mutant p53.

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p53 has a direct apoptogenic role at the mitochondria

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p53 as a therapeutic target: unresolved issues on the road to cancer therapy targeting mutant p53.

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p53 leans on its siblings

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p53 and regulation of DNA damage recognition during nucleotide excision repair

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T antigen is bound to a host protein in SY40-transformed cells

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Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndrome

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The p53 tumour suppressor gene

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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

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Cancer-susceptibility genes. Gatekeepers and caretakers

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p53 mutant mice that display early ageing-associated phenotypes

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p63 and p73 are required for p53-dependent apoptosis in response to DNA damage

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Nucleolar Arf sequesters Mdm2 and activates p53

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PAC1 phosphatase is a transcription target of p53 in signalling apoptosis and growth suppression

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Live or let die: the cell's response to p53

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Targeting gene expression to tumor cells with loss of wild-type p53 function

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Activation of p53 by roscovitine-mediated suppression of MDM2 expression

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Deconstruction of p53 functions and regulation

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Exploiting the p53 pathway for cancer diagnosis and therapy

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Post-translational modifications and activation of p53 by genotoxic stresses

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Nitric oxide-induced cellular stress and p53 activation in chronic inflammation

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Rescue of mutants of the tumor suppressor p53 in cancer cells by a designed peptide

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Increased p53 mutation load in nontumorous human liver of wilson disease and hemochromatosis: oxyradical overload diseases

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Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse

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p53 tumor suppressor gene: from the basic research laboratory to the clinic--an abridged historical perspective

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A role for p53 in base excision repair.

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"Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally

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Ser-249 p53 mutations in plasma DNA of patients with hepatocellular carcinoma from The Gambia

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p53 mutations in human cancers

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Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms

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Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene

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Apoptosis - the p53 network

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