Live or let die: the cell's response to p53 (Q29547663)

Europe PubMed Central

title

Live or let die: the cell's response to p53 (English)

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23 April 2017

author name string

Vousden KH

series ordinal

1

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23 April 2017

Lu X

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2

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12154352

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12154352

23 April 2017

language of work or name

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23 April 2017

publication date

August 2002

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12154352

23 April 2017

published in

Nature Reviews Cancer

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23 April 2017

volume

2

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23 April 2017

issue

8

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23 April 2017

page(s)

594-604

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Proliferation, cell cycle and apoptosis in cancer

23 April 2017

cites work

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Activation and activities of the p53 tumour suppressor protein

31 March 2020

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Two functional assays employed to detect an unusual mutation in the oligomerisation domain of p53 in a Li-Fraumeni like family

31 March 2020

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A novel mechanism of tumorigenesis involving pH-dependent destabilization of a mutant p53 tetramer

31 March 2020

1 reference

31 March 2020

p53: puzzle and paradigm

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Targeted point mutations of p53 lead to dominant-negative inhibition of wild-type p53 function

31 March 2020

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High metastatic potential in mice inheriting a targeted p53 missense mutation

31 March 2020

1 reference

A mutant p53 transgene accelerates tumour development in heterozygous but not nullizygous p53-deficient mice

31 March 2020

1 reference

Mutant p53 gain of function: differential effects of different p53 mutants on resistance of cultured cells to chemotherapy

31 March 2020

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p73 function is inhibited by tumor-derived p53 mutants in mammalian cells.

31 March 2020

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A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain

31 March 2020

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Physical and Functional Interaction between p53 Mutants and Different Isoforms of p73

31 March 2020

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Physical interaction with human tumor-derived p53 mutants inhibits p63 activities.

31 March 2020

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A common polymorphism acts as an intragenic modifier of mutant p53 behaviour

31 March 2020

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Regulation of p53 function

31 March 2020

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Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

31 March 2020

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Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

31 March 2020

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Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53

31 March 2020

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Deregulated beta-catenin induces a p53- and ARF-dependent growth arrest and cooperates with Ras in transformation

31 March 2020

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Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors.

31 March 2020

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31 March 2020

Oncogenes and cell death

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A matter of life and death

31 March 2020

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The TRAIL decoy receptor TRUNDD (DcR2, TRAIL-R4) is induced by adenovirus-p53 overexpression and can delay TRAIL-, p53-, and KILLER/DR5-dependent colon cancer apoptosis

31 March 2020

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p53 induction of heparin-binding EGF-like growth factor counteracts p53 growth suppression through activation of MAPK and PI3K/Akt signaling cascades

31 March 2020

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A model for p53-induced apoptosis

31 March 2020

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Identification and classification of p53-regulated genes

31 March 2020

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NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription

31 March 2020

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DNA microarrays identification of primary and secondary target genes regulated by p53.

31 March 2020

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Analyses of p53 target genes in the human genome by bioinformatic and microarray approaches

31 March 2020

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A polymorphic microsatellite that mediates induction of PIG3 by p53.

31 March 2020

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31 March 2020

Surfing the p53 network

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Mechanisms of p53-dependent apoptosis

31 March 2020

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Tissue and cell-specific expression of the p53-target genes: bax, fas, mdm2 and waf1/p21, before and following ionising irradiation in mice

31 March 2020

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Characterization of structural p53 mutants which show selective defects in apoptosis but not cell cycle arrest

31 March 2020

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Mdm2 Inhibits the Apoptotic Function of p53 Mainly by Targeting It for Degradation

31 March 2020

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RB regulates the stability and the apoptotic function of p53 via MDM2

31 March 2020

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Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a.

31 March 2020

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The corepressor mSin3a interacts with the proline-rich domain of p53 and protects p53 from proteasome-mediated degradation

31 March 2020

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p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes

31 March 2020

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Induction of apoptosis in HeLa cells by trans-activation-deficient p53

31 March 2020

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p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells

31 March 2020

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Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.

31 March 2020

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A transactivation-deficient mouse model provides insights into Trp53 regulation and function

31 March 2020

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p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage

31 March 2020

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Cell surface trafficking of Fas: a rapid mechanism of p53-mediated apoptosis.

31 March 2020

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Essential role for caspase-8 in transcription-independent apoptosis triggered by p53

31 March 2020

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Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling

31 March 2020

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A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy

31 March 2020

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31 March 2020

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Transcriptional activation by p53 correlates with suppression of growth but not transformation.

31 March 2020

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Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant

31 March 2020

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A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis

31 March 2020

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Differential activation of target cellular promoters by p53 mutants with impaired apoptotic function

31 March 2020

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Kinetics of p53 binding to promoter sites in vivo

31 March 2020

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Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo

31 March 2020

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Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment.

31 March 2020

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DNA damage activates p53 through a phosphorylation-acetylation cascade

31 March 2020

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Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

31 March 2020

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31 March 2020

Why is p53 acetylated?

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A novel cofactor for p300 that regulates the p53 response

31 March 2020

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ASPP proteins specifically stimulate the apoptotic function of p53

31 March 2020

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p63 and p73 are required for p53-dependent apoptosis in response to DNA damage

31 March 2020

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31 March 2020

E2F-1 induced apoptosis

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Role for the p53 homologue p73 in E2F-1-induced apoptosis

31 March 2020

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Role of the p53-homologue p73 in E2F1-induced apoptosis

31 March 2020

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Novel function of the cyclin A binding site of E2F in regulating p53-induced apoptosis in response to DNA damage

31 March 2020

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NF-kappaB at the crossroads of life and death

31 March 2020

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Transcriptional cross talk between NF-kappaB and p53.

31 March 2020

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Role of NF-κB in p53-mediated programmed cell death

31 March 2020

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The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death

31 March 2020

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p53-mediated apoptosis and genomic instability diseases

31 March 2020

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p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53

31 March 2020

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Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation

31 March 2020

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Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.

31 March 2020

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Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2

31 March 2020

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p53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation

31 March 2020

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ATM mediates phosphorylation at multiple p53 sites, including Ser(46), in response to ionizing radiation

31 March 2020

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p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis

31 March 2020

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Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner

31 March 2020

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DNA damage-dependent acetylation of p73 dictates the selective activation of apoptotic target genes.

31 March 2020

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31 March 2020

The ins and outs of p53

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Molecular biology. Getting p53 out of the nucleus.

31 March 2020

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Regulation of p53 activity in nuclear bodies by a specific PML isoform

31 March 2020

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The function of PML in p53-dependent apoptosis

31 March 2020

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PML regulates p53 acetylation and premature senescence induced by oncogenic Ras

31 March 2020

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P53 and PML: new partners in tumor suppression

31 March 2020

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Phosphoinositide 3-OH kinase (PI3K) and PKB/Akt delay the onset of p53-mediated, transcriptionally dependent apoptosis

31 March 2020

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A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

31 March 2020

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HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

31 March 2020

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WISP-1 attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase

31 March 2020

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Akt activation protects hippocampal neurons from apoptosis by inhibiting transcriptional activity of p53.

31 March 2020

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Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals

31 March 2020

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Regulation of PTEN transcription by p53

31 March 2020

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Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.

31 March 2020

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Pharmacological rescue of mutant p53 conformation and function

31 March 2020

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A peptide that binds and stabilizes p53 core domain: chaperone strategy for rescue of oncogenic mutants

31 March 2020

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A common E2F-1 and p73 pathway mediates cell death induced by TCR activation.

31 March 2020

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Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB.

31 March 2020

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Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity

31 March 2020

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Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition.

31 March 2020

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Inactivation of the apoptosis effector Apaf-1 in malignant melanoma

31 March 2020

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Bax loss impairs Myc-induced apoptosis and circumvents the selection of p53 mutations during Myc-mediated lymphomagenesis

31 March 2020

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p53 regulates cell survival by inhibiting PIK3CA in squamous cell carcinomas

31 March 2020

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p73: Friend or foe in tumorigenesis

31 March 2020

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Apaf-1 is a transcriptional target for E2F and p53

31 March 2020

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APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death.

31 March 2020

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A novel form of Epstein-Barr virus latency in normal B cells in vivo

31 March 2020

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Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression

31 March 2020

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Ferredoxin reductase affects p53-dependent, 5-fluorouracil-induced apoptosis in colorectal cancer cells

31 March 2020

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Induction of the growth inhibitor IGF-binding protein 3 by p53

31 March 2020

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KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene

31 March 2020

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Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

31 March 2020

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Pidd, a new death-domain-containing protein, is induced by p53 and promotes apoptosis

31 March 2020

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ei24, a p53 response gene involved in growth suppression and apoptosis

31 March 2020

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PUMA, a novel proapoptotic gene, is induced by p53

31 March 2020

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PUMA induces the rapid apoptosis of colorectal cancer cells

31 March 2020

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Identification of BTG2, an antiproliferative p53-dependent component of the DNA damage cellular response pathway

31 March 2020

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WAF1, a potential mediator of p53 tumor suppression

31 March 2020

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14-3-3sigma is a p53-regulated inhibitor of G2/M progression

31 March 2020

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A ribonucleotide reductase gene is a transcriptional target of p53 and p73

31 March 2020

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A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage

31 March 2020

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Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1

31 March 2020

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Release of an inhibitor of angiogenesis upon induction of wild type p53 expression in glioblastoma cells

31 March 2020

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A novel brain-specific p53-target gene, BAI1, containing thrombospondin type 1 repeats inhibits experimental angiogenesis

31 March 2020

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Transcriptional activation by p53 of the human type IV collagenase (gelatinase A or matrix metalloproteinase 2) promoter

31 March 2020

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p53 regulates the expression of the tumor suppressor gene maspin

31 March 2020

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The expression of the KAI1 gene, a tumor metastasis suppressor, is directly activated by p53

31 March 2020

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mdm2 expression is induced by wild type p53 activity

31 March 2020

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The p53-mdm-2 autoregulatory feedback loop

31 March 2020

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p73 is transcriptionally regulated by DNA damage, p53, and p73

31 March 2020

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Human delta Np73 regulates a dominant negative feedback loop for TAp73 and p53.

31 March 2020

1 reference

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31 March 2020

Identifiers

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23 April 2017

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

1018869258

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Consolidated OpenCitations Corpus – April 2017

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PubMed publication ID

2 references

23 April 2017

Consolidated OpenCitations Corpus – April 2017