A role of the Lowe syndrome protein OCRL in early steps of the endocytic pathway (Q24569564)

10

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Roberto Zoncu

4

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author name string

Kai S Erdmann

1

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Yuxin Mao

2

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Heather J McCrea

3

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Sangyoon Lee

5

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Summer Paradise

6

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Jan Modregger

7

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Daniel Biemesderfer

8

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Derek Toomre

Membrane targeting and activation of the Lowe syndrome protein OCRL1 by rab GTPases

9

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language of work or name

English

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publication date

September 2007

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published in

Developmental Cell

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volume

13

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issue

3

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page(s)

377-90

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cites work

1 reference

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APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function

24 March 2017

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Lowe syndrome protein OCRL1 interacts with clathrin and regulates protein trafficking between endosomes and the trans-Golgi network

24 March 2017

1 reference

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Dent Disease with mutations in OCRL1

24 March 2017

1 reference

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APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment

24 March 2017

1 reference

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The Adaptor Protein ARH Escorts Megalin to and through Endosomes

24 March 2017

1 reference

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A conserved ER targeting motif in three families of lipid binding proteins and in Opi1p binds VAP

24 March 2017

1 reference

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Mediation of the DCC apoptotic signal by DIP13 alpha

24 March 2017

1 reference

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GIPC and GAIP form a complex with TrkA: a putative link between G protein and receptor tyrosine kinase pathways

24 March 2017

1 reference

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Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2

24 March 2017

1 reference

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Properties of type II inositol polyphosphate 5-phosphatase

24 March 2017

1 reference

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The Lowe's oculocerebrorenal syndrome gene encodes a protein highly homologous to inositol polyphosphate-5-phosphatase

24 March 2017

1 reference

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Specificity determinants in phosphoinositide dephosphorylation: crystal structure of an archetypal inositol polyphosphate 5-phosphatase

24 March 2017

1 reference

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Peptide-in-groove interactions link target proteins to the beta-propeller of clathrin

24 March 2017

1 reference

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Phosphoinositides in cell regulation and membrane dynamics

24 March 2017

1 reference

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XtalView/Xfit--A versatile program for manipulating atomic coordinates and electron density

24 March 2017

1 reference

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

24 March 2017

1 reference

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Neurotrophin signal transduction in the nervous system

24 March 2017

1 reference

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The Saccharomyces cerevisiae SCS2 gene product, a homolog of a synaptobrevin-associated protein, is an integral membrane protein of the endoplasmic reticulum and is required for inositol metabolism

24 March 2017

1 reference

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The protein deficient in Lowe syndrome is a phosphatidylinositol-4,5-bisphosphate 5-phosphatase

24 March 2017

1 reference

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Binding of internalized receptors to the PDZ domain of GIPC/synectin recruits myosin VI to endocytic vesicles

24 March 2017

1 reference

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Lowe syndrome protein Ocrl1 is translocated to membrane ruffles upon Rac GTPase activation: a new perspective on Lowe syndrome pathophysiology

24 March 2017

1 reference

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Human RhoGAP domain-containing proteins: structure, function and evolutionary relationships

24 March 2017

1 reference

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GAIP, GIPC and Galphai3 are concentrated in endocytic compartments of proximal tubule cells: putative role in regulating megalin's function

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2025683

Disrupted sperm function and fertilin beta processing in mice deficient in the inositol polyphosphate 5-phosphatase Inpp5b

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2025683

Essential role of phosphoinositide metabolism in synaptic vesicle recycling

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2025683

The immunoglobulin fold. Structural classification, sequence patterns and common core

24 March 2017

1 reference

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Functional overlap between murine Inpp5b and Ocrl1 may explain why deficiency of the murine ortholog for OCRL1 does not cause Lowe syndrome in mice

24 March 2017

1 reference

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Retrograde transport from endosomes to the trans-Golgi network

24 March 2017

1 reference

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Loss of endocytic clathrin-coated pits upon acute depletion of phosphatidylinositol 4,5-bisphosphate.

7 April 2017

1 reference

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PTEN-mediated apical segregation of phosphoinositides controls epithelial morphogenesis through Cdc42.

27 September 2017

1 reference

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PKB and megalin determine the survival or death of renal proximal tubule cells

27 September 2017

1 reference

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GIPC is recruited by APPL to peripheral TrkA endosomes and regulates TrkA trafficking and signaling

27 September 2017

1 reference

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APPL1 associates with TrkA and GIPC1 and is required for nerve growth factor-mediated signal transduction

27 September 2017

1 reference

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Regulation of phosphoinositide signaling by the inositol polyphosphate 5-phosphatases.

27 September 2017

1 reference

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Spatial dynamics of receptor-mediated endocytic trafficking in budding yeast revealed by using fluorescent alpha-factor derivatives

27 September 2017

1 reference

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An enzymatic cascade of Rab5 effectors regulates phosphoinositide turnover in the endocytic pathway

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2025683

Structure and function of the Lowe syndrome protein OCRL1.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2025683

Structural basis of FFAT motif-mediated ER targeting

27 September 2017

1 reference

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Mutually dependent localization of megalin and Dab2 in the renal proximal tubule.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2025683

Regulation of the interaction between PIPKI gamma and talin by proline-directed protein kinases

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2025683

The inositol polyphosphate 5-phosphatase Ocrl associates with endosomes that are partially coated with clathrin

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2025683

Human follicle-stimulating hormone (FSH) receptor interacts with the adaptor protein APPL1 in HEK 293 cells: potential involvement of the PI3K pathway in FSH signaling

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2025683

Ocrl1, a PtdIns(4,5)P(2) 5-phosphatase, is localized to the trans-Golgi network of fibroblasts and epithelial cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2025683

Megalin knockout mice as an animal model of low molecular weight proteinuria.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2025683

Albumin endocytosis in OK cells: dependence on actin and microtubules and regulation by protein kinases

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2025683

The oculocerebrorenal syndrome gene product is a 105-kD protein localized to the Golgi complex

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2025683

Presence of an extensive clathrin coat on the apical plasmalemma of the rat kidney proximal tubule cell

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2025683

A novel domain suggests a ciliary function for ASPM, a brain size determining gene

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2025683

The effect of missense mutations in the RhoGAP-homology domain on ocrl1 function.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2025683

Type II phosphoinositide 5-phosphatases have unique sensitivities towards fatty acid composition and head group phosphorylation

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2025683

Linking receptor-mediated endocytosis and cell signaling: evidence for regulated intramembrane proteolysis of megalin in proximal tubule

28 November 2018

1 reference

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Urinary megalin deficiency implicates abnormal tubular endocytic function in Fanconi syndrome

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2025683

ClC-5 Cl- -channel disruption impairs endocytosis in a mouse model for Dent's disease.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2025683

OCRL1 mutation analysis in French Lowe syndrome patients: implications for molecular diagnosis strategy and genetic counseling.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2025683

A sensitive assay for phosphoinositide phosphatases

28 November 2018

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12 December 2020

Processing of X-ray diffraction data collected in oscillation mode

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12 December 2020

Receptor-induced transient reduction in plasma membrane PtdIns(4,5)P2 concentration monitored in living cells

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12 December 2020

The Immunoglobulin Fold

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12 December 2020