A TSG101/MDM2 regulatory loop modulates MDM2 degradation and MDM2/p53 feedback control (Q24621472)

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J Liao

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T W Mak

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S N Cohen

Proceedings of the National Academy of Sciences of the United States of America

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language of work or name

English

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publication date

13 February 2001

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published in

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volume

98

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issue

4

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page(s)

1619-24

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cites work

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ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

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Tumor susceptibility gene 101 protein represses androgen receptor transactivation and interacts with p300

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Aberrant splicing of the TSG101 and FHIT genes occurs frequently in multiple malignancies and in normal tissues and mimics alterations previously described in tumours

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TSG101 protein steady-state level is regulated posttranslationally by an evolutionarily conserved COOH-terminal sequence.

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Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.

27 September 2017

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Amplification of MDM2 inhibits MyoD-mediated myogenesis

27 September 2017

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27 September 2017

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A putative tumor suppressor, TSG101, acts as a transcriptional suppressor through its coiled-coil domain

27 September 2017

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MDM2--arbiter of p53's destruction

30 May 2018

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Tsg101: a novel tumor susceptibility gene isolated by controlled homozygous functional knockout of allelic loci in mammalian cells

30 May 2018

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Identification and characterization of multiple mdm-2 proteins and mdm-2-p53 protein complexes

30 May 2018

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Regulation of the p53 protein by the MDM2 oncoprotein--thirty-eighth G.H.A. Clowes Memorial Award Lecture

30 May 2018

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The breast cancer gene product TSG101: a regulator of ubiquitination?

28 November 2018

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mdm2 deletion does not alter growth characteristics of p53-deficient embryo fibroblasts

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12 December 2020

Stress-induced aberrant splicing of TSG101: association to high tumor grade and p53 status in breast cancers

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12 December 2020

Frequent abnormalities of TSG101 transcripts in human prostate cancer

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12 December 2020

Signaling to p53: breaking the MDM2-p53 circuit

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12 December 2020