Cell damage-induced conformational changes of the pro-apoptotic protein Bak in vivo precede the onset of apoptosis (Q24670370)

7

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author name string

G J Griffiths

1

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C P Morgan

3

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N A Jones

4

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J Whitehouse

5

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B M Corfe

6

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J A Hickman

Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis

8

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language of work or name

English

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publication date

8 March 1999

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published in

Journal of Cell Biology

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volume

144

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issue

5

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page(s)

903-14

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cites work

1 reference

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Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria

7 April 2017

1 reference

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Movement of Bax from the cytosol to mitochondria during apoptosis

7 April 2017

1 reference

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Daxx, a Novel Fas-Binding Protein That Activates JNK and Apoptosis

7 April 2017

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BID: a novel BH3 domain-only death agonist

7 April 2017

1 reference

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A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions

7 April 2017

1 reference

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Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

7 April 2017

1 reference

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bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

7 April 2017

1 reference

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Multiple Bcl-2 family members demonstrate selective dimerizations with Bax

7 April 2017

1 reference

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Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

7 April 2017

1 reference

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Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo

7 April 2017

1 reference

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Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K

7 April 2017

1 reference

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Bcl-2 and Bax function independently to regulate cell death

7 April 2017

1 reference

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Proapoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain (BH3) distinct from BH1 and BH2

7 April 2017

1 reference

Crossref

https://api.crossref.org/works/10.1083/JCB.144.5.903

Commitment to cell death measured by loss of clonogenicity is separable from the appearance of apoptotic markers

22 April 2017

1 reference

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Subcellular and submitochondrial mode of action of Bcl-2-like oncoproteins

28 September 2017

1 reference

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v-Abl protein tyrosine kinase (PTK) mediated suppression of apoptosis is associated with the up-regulation of Bcl-XL.

28 September 2017

1 reference

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Bak can accelerate chemotherapy-induced cell death independently of its heterodimerization with Bcl-XL and Bcl-2.

28 September 2017

1 reference

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Functional dissection of the pro-apoptotic protein Bik. Heterodimerization with anti-apoptosis proteins is insufficient for induction of cell death

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2148192

Germinal center-derived signals act with Bcl-2 to decrease apoptosis and increase clonogenicity of drug-treated human B lymphoma cells.

28 September 2017

1 reference

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Bcl-2 phosphorylation required for anti-apoptosis function

28 September 2017

1 reference

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Bax upregulation is an early event in cisplatin-induced apoptosis in human testicular germ-cell tumor cell line NT2, as quantitated by flow cytometry

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2148192

Inhibition of Ced-3/ICE-related proteases does not prevent cell death induced by oncogenes, DNA damage, or the Bcl-2 homologue Bak

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2148192

BAX-induced cell death may not require interleukin 1 beta-converting enzyme-like proteases

28 September 2017

1 reference

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Molecular thanatopsis: a discourse on the BCL2 family and cell death.

28 September 2017

1 reference

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Bcl-2/Bax: a rheostat that regulates an anti-oxidant pathway and cell death

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2148192

Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2148192

Tumorigenic activity of the BCR-ABL oncogenes is mediated by BCL2.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2148192

Inactivation of Bcl-2 by phosphorylation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2148192

30 KDa phosphorylated form of Bcl-2 protein in human colon

28 September 2017

1 reference

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Hypersensitivity of human testicular tumors to etoposide-induced apoptosis is associated with functional p53 and a high Bax:Bcl-2 ratio.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2148192

Bax-independent inhibition of apoptosis by Bcl-XL.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2148192

Double identity for proteins of the Bcl-2 family

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2148192

The proto-oncogene Bcl-2 and its role in regulating apoptosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2148192

Growth factor modulation of p53-mediated growth arrest versus apoptosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2148192

Anti-apoptotic oncogenes prevent caspase-dependent and independent commitment for cell death

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2148192

Phosphorylation of Bcl-2 is a marker of M phase events and not a determinant of apoptosis.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2148192

Heterodimerization-independent functions of cell death regulatory proteins Bax and Bcl-2 in yeast and mammalian cells

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2148192

Caspases: intracellular signaling by proteolysis

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2148192

Induction of apoptosis by anti-cancer drugs with disparate modes of action: kinetics of cell death and changes in c-myc expression

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2148192

Bcl-2-family proteins: the role of the BH3 domain in apoptosis

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2148192

Structure-function analysis of Bcl-2 protein. Identification of conserved domains important for homodimerization with Bcl-2 and heterodimerization with Bax.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2148192

Apoptosis meets signal transduction: elimination of a BAD influence

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/10085290

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Nonionic detergents induce dimerization among members of the Bcl-2 family

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/10085290

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Interleukin-3 and bryostatin-1 mediate hyperphosphorylation of BCL2 alpha in association with suppression of apoptosis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/10085290