Heparan sulfate as a regulator of endochondral ossification and osteochondroma development (Q26849343)

Velina Bachvarova

series ordinal

2

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Andrea Vortkamp

series ordinal

3

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language of work or name

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February 2014

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34

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PubMed

page(s)

55-63

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Reevaluation of a genetic model for the development of exostosis in hereditary multiple exostosis

PubMed

cites work

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https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Heparan sulfate Ndst1 gene function variably regulates multiple signaling pathways during mouse development

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Redundant function of the heparan sulfate 6-O-endosulfatases Sulf1 and Sulf2 during skeletal development

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Expression patterns of sulfatase genes in the developing mouse embryo

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Multiple osteochondromas: mutation update and description of the multiple osteochondromas mutation database (MOdb).

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Tiling resolution array-CGH shows that somatic mosaic deletion of the EXT gene is causative in EXT gene mutation negative multiple osteochondromas patients

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Clinical outcome and genotype in patients with hereditary multiple exostoses.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Peripheral chondrosarcoma progression is accompanied by decreased Indian Hedgehog signalling.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Cell biology of osteochondromas: bone morphogenic protein signalling and heparan sulphates

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Isolation and characterization of heparan sulfate from various murine tissues

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Defective chondrocyte proliferation and differentiation in osteochondromas of MHE patients

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

NDST-1 modulates BMPR and PTHrP signaling during endochondral bone formation in a gene knockout model

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Compound heterozygous loss of Ext1 and Ext2 is sufficient for formation of multiple exostoses in mouse ribs and long bones

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Epiphyseal abnormalities, trabecular bone loss and articular chondrocyte hypertrophy develop in the long bones of postnatal Ext1-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Ext1-dependent heparan sulfate regulates the range of Ihh signaling during endochondral ossification

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Osteoblast precursors, but not mature osteoblasts, move into developing and fractured bones along with invading blood vessels.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Sonic hedgehog shedding results in functional activation of the solubilized protein.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Brachydactyly type A1 associated with unusual radiological findings and a novel Arg158Cys mutation in the Indian hedgehog (IHH) gene.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Synovial perlecan is required for osteophyte formation in knee osteoarthritis

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Synovial joint formation requires local Ext1 expression and heparan sulfate production in developing mouse embryo limbs and spine

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Perichondrium phenotype and border function are regulated by Ext1 and heparan sulfate in developing long bones: a mechanism likely deranged in Hereditary Multiple Exostoses

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Hereditary multiple exostoses: from genetics to clinical syndrome and complications

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Interaction of FGF, Ihh/Pthlh, and BMP signaling integrates chondrocyte proliferation and hypertrophic differentiation

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Functional analysis of secreted and transmembrane proteins critical to mouse development.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Indian hedgehog mutations causing brachydactyly type A1 impair Hedgehog signal transduction at multiple levels

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Up-regulation of PTHrP and Bcl-2 expression characterizes the progression of osteochondroma towards peripheral chondrosarcoma and is a late event in central chondrosarcoma

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Developmental regulation of the growth plate

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Heparan sulphate proteoglycans fine-tune mammalian physiology

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

A mutation in Ihh that causes digit abnormalities alters its signalling capacity and range.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Ptpn11 deletion in a novel progenitor causes metachondromatosis by inducing hedgehog signalling.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

The EXT2 multiple exostoses gene defines a family of putative tumour suppressor genes

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Cloning of the putative tumour suppressor gene for hereditary multiple exostoses (EXT1)

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Mutations in IHH, encoding Indian hedgehog, cause brachydactyly type A-1

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivo

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

A mouse model of osteochondromagenesis from clonal inactivation of Ext1 in chondrocytes.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Extracellular sulfatases support cartilage homeostasis by regulating BMP and FGF signaling pathways

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

A mouse model of chondrocyte-specific somatic mutation reveals a role for Ext1 loss of heterozygosity in multiple hereditary exostoses

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Structural insights into proteoglycan-shaped Hedgehog signaling

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Defect in 3'-phosphoadenosine 5'-phosphosulfate formation in brachymorphic mice

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

The putative tumor suppressors EXT1 and EXT2 are glycosyltransferases required for the biosynthesis of heparan sulfate

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Targeted disruption of a murine glucuronyl C5-epimerase gene results in heparan sulfate lacking L-iduronic acid and in neonatal lethality

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Heparan sulfate proteoglycans retain Noggin at the cell surface: a potential mechanism for shaping bone morphogenetic protein gradients

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Conditional ablation of the heparan sulfate-synthesizing enzyme Ext1 leads to dysregulation of bone morphogenic protein signaling and severe skeletal defects

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Dual roles of the Cardin-Weintraub motif in multimeric Sonic hedgehog.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Two distinct sites in sonic Hedgehog combine for heparan sulfate interactions and cell signaling functions

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Transglutaminase-2 interaction with heparin: identification of a heparin binding site that regulates cell adhesion to fibronectin-transglutaminase-2 matrix

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

An emerging role of Sonic hedgehog shedding as a modulator of heparan sulfate interactions

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

On the roles and regulation of chondroitin sulfate and heparan sulfate in zebrafish pharyngeal cartilage morphogenesis

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Heparan sulfate proteoglycans containing a glypican 5 core and 2-O-sulfo-iduronic acid function as Sonic Hedgehog co-receptors to promote proliferation

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Embryonic fibroblasts with a gene trap mutation in Ext1 produce short heparan sulfate chains

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Heparan sulfate structure in mice with genetically modified heparan sulfate production

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Cell-surface heparan sulfate proteoglycans potentiate chordin antagonism of bone morphogenetic protein signaling and are necessary for cellular uptake of chordin

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Substrate specificity and domain functions of extracellular heparan sulfate 6-O-endosulfatases, QSulf1 and QSulf2.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Mice deficient in heparan sulfate 6-O-sulfotransferase-1 exhibit defective heparan sulfate biosynthesis, abnormal placentation, and late embryonic lethality

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Mutations in the EXT1 and EXT2 genes in hereditary multiple exostoses

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

EXT-mutation analysis and loss of heterozygosity in sporadic and hereditary osteochondromas and secondary chondrosarcomas.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Down-regulated HS6ST2 in osteoarthritis and Kashin-Beck disease inhibits cell viability and influences expression of the genes relevant to aggrecan metabolism of human chondrocytes

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Heparan sulfate proteoglycans

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Renal agenesis in mice homozygous for a gene trap mutation in the gene encoding heparan sulfate 2-sulfotransferase

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Genotype-phenotype correlation in hereditary multiple exostoses

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Functions of cell surface heparan sulfate proteoglycans

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Order out of chaos: assembly of ligand binding sites in heparan sulfate

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Chondrocyte proliferation and differentiation

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Molecular modeling of protein-glycosaminoglycan interactions.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Molecular diversity of heparan sulfate

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Sulfotransferase Ndst1 is needed for mandibular and TMJ development

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Expression of novel extracellular sulfatases Sulf-1 and Sulf-2 in normal and osteoarthritic articular cartilage

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Cerebral hypoplasia and craniofacial defects in mice lacking heparan sulfate Ndst1 gene function

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Mice deficient in Ext2 lack heparan sulfate and develop exostoses

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

BMPs regulate multiple aspects of growth-plate chondrogenesis through opposing actions on FGF pathways.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Sulfation of chondroitin sulfate proteoglycans is necessary for proper Indian hedgehog signaling in the developing growth plate

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Severity of disease and risk of malignant change in hereditary multiple exostoses. A genotype-phenotype study

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

EXT 1 gene mutation induces chondrocyte cytoskeletal abnormalities and defective collagen expression in the exostoses

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Regulation of zebrafish skeletogenesis by ext2/dackel and papst1/pinscher

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Secreted sulfatases Sulf1 and Sulf2 have overlapping yet essential roles in mouse neonatal survival

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

The natural history of hereditary multiple exostoses

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Genotype-phenotype correlation study in 529 patients with multiple hereditary exostoses: identification of "protective" and "risk" factors.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Constitutive hedgehog signaling in chondrosarcoma up-regulates tumor cell proliferation

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

No haploinsufficiency but loss of heterozygosity for EXT in multiple osteochondromas

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021

Induction and patterning of intramembranous bone

1 reference

https://api.crossref.org/works/10.1016%2FJ.MATBIO.2013.11.003

7 January 2021