Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles' heel? (Q26852282)

Paul T. Schumacker

series ordinal

2

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language of work or name

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November 2014

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published in

Nature Reviews Cancer

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volume

14

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issue

11

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page(s)

709-21

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The maintenance of mitochondrial DNA integrity--critical analysis and update

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Role of oxidants in NF-kappa B activation and TNF-alpha gene transcription induced by hypoxia and endotoxin

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Dimers of mitochondrial ATP synthase form the permeability transition pore

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Peroxiredoxins: a historical overview and speculative preview of novel mechanisms and emerging concepts in cell signaling

7 April 2017

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Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death

7 April 2017

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Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase

7 April 2017

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The mtDNA T8993G (NARP) mutation results in an impairment of oxidative phosphorylation that can be improved by antioxidants

7 April 2017

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The R22X mutation of the SDHD gene in hereditary paraganglioma abolishes the enzymatic activity of complex II in the mitochondrial respiratory chain and activates the hypoxia pathway

7 April 2017

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A thiol-specific antioxidant and sequence homology to various proteins of unknown function

7 April 2017

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Thioredoxin and glutaredoxin systems

7 April 2017

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Mitochondrial genome instability and ROS enhance intestinal tumorigenesis in APC(Min/+) mice

7 April 2017

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Motexafin gadolinium, a tumor-selective drug targeting thioredoxin reductase and ribonucleotide reductase

7 April 2017

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Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

7 April 2017

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Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

7 April 2017

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Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

7 April 2017

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Eukaryotic evolution, changes and challenges

7 April 2017

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Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer

7 April 2017

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HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability

7 April 2017

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Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing

7 April 2017

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Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability

7 April 2017

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Reversible inactivation of the tumor suppressor PTEN by H2O2

7 April 2017

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Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing

7 April 2017

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Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma

7 April 2017

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Mitochondrial reactive oxygen species trigger hypoxia-induced transcription

7 April 2017

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Hydroperoxide metabolism in mammalian organs

7 April 2017

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Tumorigenicity of hypoxic respiring cancer cells revealed by a hypoxia-cell cycle dual reporter

7 April 2017

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Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells

28 September 2017

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Quantitative flux analysis reveals folate-dependent NADPH production.

28 September 2017

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The 2-oxoacid dehydrogenase complexes in mitochondria can produce superoxide/hydrogen peroxide at much higher rates than complex I

28 September 2017

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Peroxiredoxin-5 targeted to the mitochondrial intermembrane space attenuates hypoxia-induced reactive oxygen species signalling

28 September 2017

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HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations

28 September 2017

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The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling.

28 September 2017

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ROS-mediated PARP activity undermines mitochondrial function after permeability transition pore opening during myocardial ischemia-reperfusion

28 September 2017

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PGC1α expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress.

28 September 2017

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28 September 2017

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Superoxide generated at mitochondrial complex III triggers acute responses to hypoxia in the pulmonary circulation.

28 September 2017

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28 September 2017

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Brief hyperoxia increases mitochondrial oxidation and increases phosphodiesterase 5 activity in fetal pulmonary artery smooth muscle cells.

28 September 2017

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Reductive carboxylation supports growth in tumour cells with defective mitochondria.

28 September 2017

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Genomic instability induced by mutant succinate dehydrogenase subunit D (SDHD) is mediated by O2(-•) and H2O2.

28 September 2017

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K-ras(G12V) transformation leads to mitochondrial dysfunction and a metabolic switch from oxidative phosphorylation to glycolysis

28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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Hypoxia triggers subcellular compartmental redox signaling in vascular smooth muscle cells

28 September 2017

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Prolonged hypoxia increases ROS signaling and RhoA activation in pulmonary artery smooth muscle and endothelial cells

28 September 2017

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Fumarate hydratase deficiency in renal cancer induces glycolytic addiction and hypoxia-inducible transcription factor 1alpha stabilization by glucose-dependent generation of reactive oxygen species.

28 September 2017

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A mitochondrial DNA mutation linked to colon cancer results in proton leaks in cytochrome c oxidase

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28 September 2017

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Regulation of cancer cell metabolism by hypoxia-inducible factor 1.

28 September 2017

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Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response

28 September 2017

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ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis

28 September 2017

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Loss of the SdhB, but Not the SdhA, subunit of complex II triggers reactive oxygen species-dependent hypoxia-inducible factor activation and tumorigenesis.

28 September 2017

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HIF-dependent antitumorigenic effect of antioxidants in vivo

28 September 2017

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Sulfiredoxin, the cysteine sulfinic acid reductase specific to 2-Cys peroxiredoxin: its discovery, mechanism of action, and biological significance

28 September 2017

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Hypoxia-inducible factors, stem cells, and cancer

28 September 2017

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The thioredoxin system in cancer

28 September 2017

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Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate.

28 September 2017

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Reactive oxygen species in cancer cells: live by the sword, die by the sword.

28 September 2017

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Mitochondrial DNA mutations in human cancer

28 September 2017

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Oxygen sensing by mitochondria at complex III: the paradox of increased reactive oxygen species during hypoxia.

28 September 2017

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Mitochondrial regulation of oxygen sensing

28 September 2017

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Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation

28 September 2017

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Nuclear and mitochondrial DNA repair: similar pathways?

28 September 2017

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Myc stimulates nuclearly encoded mitochondrial genes and mitochondrial biogenesis

28 September 2017

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A targeted antioxidant reveals the importance of mitochondrial reactive oxygen species in the hypoxic signaling of HIF-1alpha.

28 September 2017

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mtDNA mutations increase tumorigenicity in prostate cancer

28 September 2017

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Reversible oxidation and inactivation of the tumor suppressor PTEN in cells stimulated with peptide growth factors

28 September 2017

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Evolution of mitochondrial gene content: gene loss and transfer to the nucleus

28 September 2017

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28 September 2017

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Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer

28 September 2017

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Inborn errors of complex II--unusual human mitochondrial diseases

28 September 2017

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An overview of endosymbiotic models for the origins of eukaryotes, their ATP-producing organelles (mitochondria and hydrogenosomes), and their heterotrophic lifestyle

28 September 2017

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High frequency of mitochondrial DNA mutations in glioblastoma multiforme identified by direct sequence comparison to blood samples

28 September 2017

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Progress in understanding structure-function relationships in respiratory chain complex II.

28 September 2017

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Function of the c-Myc oncogenic transcription factor.

28 September 2017

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28 September 2017

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Somatic mutations of the mitochondrial genome in human colorectal tumours

28 September 2017

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c-Myc transactivation of LDH-A: implications for tumor metabolism and growth

28 September 2017

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28 September 2017

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Complex mitochondrial DNA in leukemic and normal human myeloid cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657553

Failure of high-dose vitamin C (ascorbic acid) therapy to benefit patients with advanced cancer. A controlled trial

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657553

Mitochondrial oxidant stress triggers cell death in simulated ischemia-reperfusion.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657553

Voltage-dependent anion channels control the release of the superoxide anion from mitochondria to cytosol.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657553

Superoxide-driven aconitase FE-S center cycling

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657553

In vivo accumulation of 8-hydroxy-2'-deoxyguanosine in DNA correlates with release of reactive oxygen species in Fanconi's anaemia families

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657553

Comprehensive scanning of somatic mitochondrial DNA alterations in acute leukemia developing from myelodysplastic syndromes.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657553

Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation

19 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657553

Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657553

Positive contribution of pathogenic mutations in the mitochondrial genome to the promotion of cancer by prevention from apoptosis

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657553

SDHD mutations in head and neck paragangliomas result in destabilization of complex II in the mitochondrial respiratory chain with loss of enzymatic activity and abnormal mitochondrial morphology.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657553

Mitochondrial oxidative stress causes chromosomal instability of mouse embryonic fibroblasts

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657553

Altitude is a phenotypic modifier in hereditary paraganglioma type 1: evidence for an oxygen-sensing defect

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657553

Menadione-induced apoptosis: roles of cytosolic Ca(2+) elevations and the mitochondrial permeability transition pore

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657553

High frequency of homoplasmic mitochondrial DNA mutations in human tumors can be explained without selection

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657553

Hydrogen peroxide is not released following reaction of cyanide with several catalytically important derivatives of cytochrome c oxidase

28 November 2018

1 reference

Specific aquaporins facilitate the diffusion of hydrogen peroxide across membranes

31 March 2020

1 reference

Increases in mitochondrial reactive oxygen species trigger hypoxia-induced calcium responses in pulmonary artery smooth muscle cells

31 March 2020

1 reference

Circular Dimer and Catenate Forms of Mitochondrial DNA in Human Leukaemic Leucocytes

31 March 2020

1 reference

Mitochondrial dysfunction leads to telomere attrition and genomic instability

31 March 2020

1 reference

The isolation and purification of a specific "protector" protein which inhibits enzyme inactivation by a thiol/Fe(III)/O2 mixed-function oxidation system

31 March 2020

1 reference

https://pubmed.ncbi.nlm.nih.gov/25342630

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRC3803

1 reference

Dimensions Publication ID

1029306453

0 references

Fatcat ID

release_lwz4gxnqvncevhkzs744bnxesu

0 references

1 reference

1 reference

PubMed publication ID

25342630

1 reference