Motexafin gadolinium, a tumor-selective drug targeting thioredoxin reductase and ribonucleotide reductase (Q28567883)

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16481328%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

title

Motexafin gadolinium, a tumor-selective drug targeting thioredoxin reductase and ribonucleotide reductase (English)

2 references

31 January 2017

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16 January 2020

1 reference

1

1 reference

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16 January 2020

Farnaz Zahedi Avval

series ordinal

3

1 reference

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16 January 2020

author name string

Johanna S Ungerstedt

series ordinal

2

1 reference

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16 January 2020

Arne Holmgren

series ordinal

4

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16 January 2020

language of work or name

English

0 references

publication date

14 February 2006

1 reference

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Journal of Biological Chemistry

16 January 2020

published in

2 references

31 January 2017

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16 January 2020

volume

281

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31 January 2017

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16 January 2020

issue

16

2 references

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16 January 2020

page(s)

10691-10697

1 reference

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Texaphyrins: new drugs with diverse clinical applications in radiation and photodynamic therapy

16 January 2020

cites work

1 reference

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Lead-in phase to randomized trial of motexafin gadolinium and whole-brain radiation for patients with brain metastases: centralized assessment of magnetic resonance imaging, neurocognitive, and neurologic end points

21 January 2018

1 reference

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Neurocognitive function and progression in patients with brain metastases treated with whole-brain radiation and motexafin gadolinium: results of a randomized phase III trial

21 January 2018

1 reference

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Gadolinium(III) texaphyrin: a tumor selective radiation sensitizer that is detectable by MRI.

21 January 2018

1 reference

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Redox cycling by motexafin gadolinium enhances cellular response to ionizing radiation by forming reactive oxygen species

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511373200

Effects of Motexafin gadolinium on tumor metabolism and radiation sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511373200

Effects of texaphyrins on the oxygenation of EMT6 mouse mammary tumors

21 January 2018

1 reference

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Motexafin gadolinium generates reactive oxygen species and induces apoptosis in sensitive and highly resistant multiple myeloma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511373200

Motexafin gadolinium disrupts zinc metabolism in human cancer cell lines

21 January 2018

1 reference

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Ribonucleotide reductases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511373200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511373200

Physiological functions of thioredoxin and thioredoxin reductase

21 January 2018

1 reference

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Distinct effects of thioredoxin and antioxidants on the activation of transcription factors NF-kappa B and AP-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511373200

Antioxidant function of thioredoxin and glutaredoxin systems

21 January 2018

1 reference

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Essential role of selenium in the catalytic activities of mammalian thioredoxin reductase revealed by characterization of recombinant enzymes with selenocysteine mutations

21 January 2018

1 reference

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Structure and mechanism of mammalian thioredoxin reductase: the active site is a redox-active selenolthiol/selenenylsulfide formed from the conserved cysteine-selenocysteine sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511373200

Up-regulation of thioredoxin and thioredoxin reductase in human malignant pleural mesothelioma

21 January 2018

1 reference

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Overexpressed human mitochondrial thioredoxin confers resistance to oxidant-induced apoptosis in human osteosarcoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511373200

The thioredoxin system—From science to clinic

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511373200

Structure and function of the radical enzyme ribonucleotide reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511373200

Mutagenesis of structural half-cystine residues in human thioredoxin and effects on the regulation of activity by selenodiglutathione.

21 January 2018

1 reference

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High-level expression in Escherichia coli of selenocysteine-containing rat thioredoxin reductase utilizing gene fusions with engineered bacterial-type SECIS elements and co-expression with the selA, selB and selC genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511373200

Purification and characterization of recombinant mouse and herpes simplex virus ribonucleotide reductase R2 subunit

21 January 2018

1 reference

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A new selenoprotein from human lung adenocarcinoma cells: purification, properties, and thioredoxin reductase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511373200

Selenocysteine, identified as the penultimate C-terminal residue in human T-cell thioredoxin reductase, corresponds to TGA in the human placental gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511373200

Three-dimensional structure of a mammalian thioredoxin reductase: implications for mechanism and evolution of a selenocysteine-dependent enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511373200

Functional evaluation of nonphagocytic NAD(P)H oxidases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511373200

Thioredoxin reductase is irreversibly modified by curcumin: a novel molecular mechanism for its anticancer activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511373200

Role of thioredoxin in the response of normal and transformed cells to histone deacetylase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511373200

The emerging role of reactive oxygen species in cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511373200

Motexafin gadolinium induces oxidative stress and apoptosis in hematologic malignancies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511373200

Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511373200

Mismatch Binding Protein-Based Mutation Detection Systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511373200

21 January 2018

Identifiers

DOI

10.1074/JBC.M511373200

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16481328%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

2 references

31 January 2017