Protective coupling of mitochondrial function and protein synthesis via the eIF2α kinase GCN-2 (Q27333486)

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:1904806

positive regulation of protein oxidation

1 reference

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:1904808

negative regulation of protein oxidation

1 reference

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:1904807

Stress activated transcription factor atfs-1 CELE_ZC376.7

1 reference

MRNA guanylyltransferase CELE_C03D6.3

1 reference

Eukaryotic translation initiation factor 2-alpha kinase pek-1 CELE_F46C3.1

1 reference

Serine/threonine-protein phosphatase PP1-alpha CELE_F29F11.6

1 reference

AFG3-like protein spg-7 CELE_Y47G6A.10

1 reference

Ubiquitin-like protein 5 CELE_F46F11.4

1 reference

Eukaryotic translation initiation factor 2-alpha kinase gcn-2 CELE_Y81G3A.3

1 reference

Cytochrome b-c1 complex subunit Rieske, mitochondrial CELE_F42G8.12

1 reference

Ribosomal protein S6 kinase beta CELE_Y47D3A.16

1 reference

5-demethoxyubiquinone hydroxylase, mitochondrial CELE_ZC395.2

1 reference

Target of rapamycin homolog CELE_B0261.2

1 reference

Creative Commons Attribution 4.0 International

1 reference

Brooke M Baker

1

0 references

Amrita M Nargund

series ordinal

2

0 references

Tiffany Sun

series ordinal

3

0 references

Cole M Haynes

series ordinal

4

0 references

language of work or name

English

0 references

publication date

2012

0 references

published in

PLOS Genetics

0 references

volume

8

0 references

issue

6

0 references

page(s)

e1002760

0 references

copyright license

start time

14 June 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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Reduced cytosolic protein synthesis suppresses mitochondrial degeneration

28 September 2017

1 reference

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28 September 2017

1 reference

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Semaphorin controls epidermal morphogenesis by stimulating mRNA translation via eIF2alpha in Caenorhabditis elegans

28 September 2017

1 reference

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Quality control of mitochondria: protection against neurodegeneration and ageing

28 September 2017

1 reference

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Metabolic pathway profiling of mitochondrial respiratory chain mutants in C. elegans.

28 September 2017

1 reference

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An RNAi screen for mitochondrial proteins required to maintain the morphology of the organelle in Caenorhabditis elegans

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375257

Genomic overview of protein kinases

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375257

Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375257

Ubiquitin-like protein 5 positively regulates chaperone gene expression in the mitochondrial unfolded protein response

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375257

PKR and eIF2alpha: integration of kinase dimerization, activation, and substrate docking

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375257

Role of oxidative carbonylation in protein quality control and senescence

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375257

Decreased proteolysis caused by protein aggregates, inclusion bodies, plaques, lipofuscin, ceroid, and 'aggresomes' during oxidative stress, aging, and disease.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375257

A mitochondrial specific stress response in mammalian cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375257

Cell cycle- and swelling-induced activation of a Caenorhabditis elegans ClC channel is mediated by CeGLC-7alpha/beta phosphatases

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375257

Assaying metabolic activity in ageing Caenorhabditis elegans

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375257

Translation initiation: adept at adapting

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375257

Structural and functional conservation of the Caenorhabditis elegans timing gene clk-1.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375257

Mutations in the clk-1 gene of Caenorhabditis elegans affect developmental and behavioral timing.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375257

The eIF-2 alpha kinases: regulators of protein synthesis in starvation and stress

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375257

Protein sorting to mitochondria: evolutionary conservations of folding and assembly

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375257

Truncated protein phosphatase GLC7 restores translational activation of GCN4 expression in yeast mutants defective for the eIF-2 alpha kinase GCN2

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375257

Caenorhabditis elegans diet significantly affects metabolic profile, mitochondrial DNA levels, lifespan and brood size

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375257

Role of mitogen-activated protein kinase Sty1 in regulation of eukaryotic initiation factor 2alpha kinases in response to environmental stress in Schizosaccharomyces pombe.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375257

Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones

2 June 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1002760

eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1002760

ClpP mediates activation of a mitochondrial unfolded protein response in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1002760

Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1002760

Two modes of mitochondrial dysfunction lead independently to lifespan extension in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1002760

Rates of behavior and aging specified by mitochondrial function during development

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1002760

Mitochondrial genome content is regulated during nematode development

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1002760

Paraquat--a superoxide generator--kills neurons in the rat spinal cord

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22719267

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Selective induction of mitochondrial chaperones in response to loss of the mitochondrial genome

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22719267

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PGEN.1002760

1 reference

1 reference

1 reference

PubMed publication ID

22719267

1 reference