Targeting Bcr–Abl by combining allosteric with ATP-binding-site inhibitors (Q27658951)

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• Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors

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English	Targeting Bcr–Abl by combining allosteric with ATP-binding-site inhibitors	scientific article	Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors

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instance of

scholarly article

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title

Targeting Bcr–Abl by combining allosteric with ATP-binding-site inhibitors (English)

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main subject

allosteric inhibitor

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based on heuristic

inferred from title

author

George Q. Daley

series ordinal

28

object named as

George Q Daley

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John R. Engen

object named as

John R Engen

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27

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Stephan Grzesiek

object named as

Stephan Grzesiek

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21

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Nathanael Gray

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30

object named as

Nathanael S Gray

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Sandra W Cowan-Jacob

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4

object named as

Sandra W Cowan-Jacob

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Gabriele Fendrich

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18

object named as

Gabriele Fendrich

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author name string

Jianming Zhang

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1

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Francisco J Adrián

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2

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Wolfgang Jahnke

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3

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Allen G Li

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5

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Roxana E Iacob

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6

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Taebo Sim

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7

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John Powers

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8

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Christine Dierks

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9

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Fangxian Sun

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10

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Gui-Rong Guo

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11

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Qiang Ding

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12

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Barun Okram

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13

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Yongmun Choi

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14

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Amy Wojciechowski

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15

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Xianming Deng

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16

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Guoxun Liu

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17

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André Strauss

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19

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Navratna Vajpai

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20

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Tove Tuntland

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22

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Yi Liu

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23

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Badry Bursulaya

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24

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Mohammad Azam

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25

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Paul W Manley

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26

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Markus Warmuth

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29

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language of work or name

English

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publication date

28 January 2010

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published in

Nature

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volume

463

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issue

7280

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page(s)

501-6

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Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia

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7 April 2017

Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification

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7 April 2017

Overriding imatinib resistance with a novel ABL kinase inhibitor

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N-myristoylated c-Abl tyrosine kinase localizes to the endoplasmic reticulum upon binding to an allosteric inhibitor.

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29 September 2017

Identification of BCR-ABL point mutations conferring resistance to the Abl kinase inhibitor AMN107 (nilotinib) by a random mutagenesis study

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Activity of dual SRC-ABL inhibitors highlights the role of BCR/ABL kinase dynamics in drug resistance

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

A cell-based screen for resistance of Bcr-Abl-positive leukemia identifies the mutation pattern for PD166326, an alternative Abl kinase inhibitor

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29 September 2017

Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors

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29 September 2017

Protein NMR in biomedical research

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29 September 2017

A myristoyl/phosphotyrosine switch regulates c-Abl

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29 September 2017

Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor

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29 September 2017

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29 September 2017

Comparison of imatinib mesylate, dasatinib (BMS-354825), and nilotinib (AMN107) in an N-ethyl-N-nitrosourea (ENU)-based mutagenesis screen: high efficacy of drug combinations

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2 June 2018

Solution conformations and dynamics of ABL kinase-inhibitor complexes determined by NMR substantiate the different binding modes of imatinib/nilotinib and dasatinib

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27 November 2018

Molecular basis explanation for imatinib resistance of BCR-ABL due to T315I and P-loop mutations from molecular dynamics simulations

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27 November 2018

Prediction of resistance to small molecule FLT3 inhibitors: implications for molecularly targeted therapy of acute leukemia

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27 November 2018

Characterization of a conserved structural determinant controlling protein kinase sensitivity to selective inhibitors.

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27 November 2018

Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of BCR-ABL.

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27 November 2018

BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent transcription in mice

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27 November 2018

High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance

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PubMed Central

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27 November 2018

Identifiers

DOI

10.1038/NATURE08675

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

400710

Dimensions Publication ID

1010126996

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OpenCitations bibliographic resource ID

400710

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

400710

PMC publication ID

2901986

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

400710

PubMed publication ID

20072125

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

400710

ResearchGate publication ID

41013401

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