Emi1 is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex (Q28199187)

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E Freed

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J Y Hsu

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E R Kramer

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J M Peters

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P K Jackson

Sister chromatid separation and chromosome re-duplication are regulated by different mechanisms in response to spindle damage

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language of work or name

English

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publication date

1 June 2001

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published in

Cell

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volume

105

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issue

5

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page(s)

645-55

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cites work

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Control of G1 in the developing Drosophila eye: rca1 regulates Cyclin A.

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Cyclin A is destroyed in prometaphase and can delay chromosome alignment and anaphase

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Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1

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The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation

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Components of an SCF ubiquitin ligase localize to the centrosome and regulate the centrosome duplication cycle

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Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint

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Cyclin is degraded by the ubiquitin pathway

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The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex

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Microinjection of antibody to Mad2 protein into mammalian cells in mitosis induces premature anaphase

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Anaphase is initiated by proteolysis rather than by the inactivation of maturation-promoting factor.

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The disappearance of cyclin B at the end of mitosis is regulated spatially in Drosophila cells

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Budding yeast Cdc20: a target of the spindle checkpoint.

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Early events in DNA replication require cyclin E and are blocked by p21CIP1

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The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases

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APC-mediated proteolysis of Ase1 and the morphogenesis of the mitotic spindle

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Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events

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Fission yeast Slp1: an effector of the Mad2-dependent spindle checkpoint

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A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B

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MAD2 associates with the cyclosome/anaphase-promoting complex and inhibits its activity

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Phosphorylation by Cdc28 activates the Cdc20-dependent activity of the anaphase-promoting complex

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The Polo-like kinase Cdc5p and the WD-repeat protein Cdc20p/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae

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CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition

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Mad2 transiently associates with an APC/p55Cdc complex during mitosis

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Identification of a cullin homology region in a subunit of the anaphase-promoting complex

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Whose end is destruction: cell division and the anaphase-promoting complex

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