A naturally occurring mutation in the SLC21A6 gene causing impaired membrane localization of the hepatocyte uptake transporter (Q28219109)

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12 November 2019

title

A naturally occurring mutation in the SLC21A6 gene causing impaired membrane localization of the hepatocyte uptake transporter (English)

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12 November 2019

2

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12 November 2019

Anne T. Nies

3

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12 November 2019

6

Ulrich M Zanger

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12 November 2019

author name string

Christoph Michalski

1

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12 November 2019

Andreas K Nuessler

4

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12 November 2019

Kathrin Klein

7

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12 November 2019

Michel Eichelbaum

8

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12 November 2019

Dietrich Keppler

9

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12 November 2019

Jorg Konig

10

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12 November 2019

Peter Neuhaus

5

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12 November 2019

language of work or name

English

0 references

publication date

23 August 2002

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Journal of Biological Chemistry

12 November 2019

published in

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12 November 2019

volume

277

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12 November 2019

issue

45

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12 November 2019

page(s)

43058-43063

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Transport of drugs across the hepatic sinusoidal membrane: sinusoidal drug influx and efflux in the liver

12 November 2019

cites work

1 reference

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Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane

21 January 2018

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A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters

21 January 2018

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Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family

21 January 2018

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Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver

21 January 2018

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Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1

21 January 2018

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Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide

21 January 2018

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Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6

21 January 2018

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Molecular mechanisms of genetic polymorphisms of drug metabolism

21 January 2018

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Cytochrome P450 pharmacogenetics in drug development: in vitro studies and clinical consequences

21 January 2018

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Polymorphic human cytochrome P450 enzymes: an opportunity for individualized drug treatment

21 January 2018

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Glutathione S-transferase polymorphisms and their biological consequences

21 January 2018

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Identification of functionally variant MDR1 alleles among European Americans and African Americans

21 January 2018

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Polymorphisms in OATP-C: identification of multiple allelic variants associated with altered transport activity among European- and African-Americans

21 January 2018

1 reference

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Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): allele frequencies in the Japanese population and functional analysis

21 January 2018

1 reference

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cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats

21 January 2018

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Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencing

21 January 2018

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Expression of the multidrug resistance proteins MRP2 and MRP3 in human hepatocellular carcinoma

21 January 2018

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A comprehensive set of sequence analysis programs for the VAX

21 January 2018

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Expression of the MRP gene-encoded conjugate export pump in liver and its selective absence from the canalicular membrane in transport-deficient mutant hepatocytes

21 January 2018

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Suggestions for the nomenclature of human alleles: relevance to ecogenetics, pharmacogenetics and molecular epidemiology

21 January 2018

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Polymorphism of the ABC transporter genes, MDR1, MRP1 and MRP2/cMOAT, in healthy Japanese subjects

21 January 2018

1 reference

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Polymorphisms in the ABCC2 (cMOAT/MRP2) gene found in 72 established cell lines derived from Japanese individuals: an association between single nucleotide polymorphisms in the 5'-untranslated region and exon 28.

21 January 2018

1 reference

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Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance

21 January 2018

1 reference

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Impaired protein maturation of the conjugate export pump multidrug resistance protein 2 as a consequence of a deletion mutation in Dubin-Johnson syndrome

21 January 2018

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Bile acid and xenobiotic transporters in liver

21 January 2018

1 reference

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Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo

21 January 2018

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Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver

21 January 2018

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X-HUSAR, an X-based graphical interface for the analysis of genomic sequences

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M207735200

2 references

Consolidated OpenCitations Corpus – April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12196548%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

1 reference

Consolidated OpenCitations Corpus – April 2017

2 references

Consolidated OpenCitations Corpus – April 2017