Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production (Q28245521)

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10 January 2020

title

Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production (English)

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10 January 2020

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1

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10 January 2020

Jason L. Eriksen

3

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10 January 2020

Murad Ali Khan

8

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10 January 2020

author name string

Michael Paul Murphy

2

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10 January 2020

Sarah A Sagi

4

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10 January 2020

Sascha Weggen

5

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10 January 2020

Tawnya E Smith

6

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10 January 2020

Thomas Ladd

7

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10 January 2020

Rajashaker Kache

9

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10 January 2020

Jenny Beard

10

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10 January 2020

Mark Dodson

11

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10 January 2020

Sami Merit

12

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10 January 2020

Victor V Ozols

13

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10 January 2020

Panos Z Anastasiadis

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10 January 2020

Pritam Das

15

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10 January 2020

Abdul Fauq

16

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10 January 2020

Edward H Koo

17

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10 January 2020

Todd E Golde

18

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10 January 2020

language of work or name

English

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publication date

17 April 2005

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10 January 2020

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10 January 2020

volume

11

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10 January 2020

issue

5

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10 January 2020

page(s)

545-550

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Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

10 January 2020

cites work

1 reference

Dissecting the pathological effects of human Abeta40 and Abeta42 in Drosophila: a potential model for Alzheimer's disease

20 April 2017

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20 April 2017

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

20 April 2017

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Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

20 April 2017

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20 April 2017

Alzheimer's disease beta-amyloid peptide is increased in mice deficient in endothelin-converting enzyme

20 April 2017

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Alzheimer's disease: genes, proteins, and therapy

20 April 2017

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7 January 2021

Biochemical detection of Abeta isoforms: implications for pathogenesis, diagnosis, and treatment of Alzheimer's disease

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7 January 2021

The role of A beta 42 in Alzheimer's disease

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7 January 2021

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1 reference

7 January 2021

NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo

1 reference

7 January 2021

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

1 reference

7 January 2021

Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity

1 reference

7 January 2021

The non-cyclooxygenase targets of non-steroidal anti-inflammatory drugs, lipoxygenases, peroxisome proliferator-activated receptor, inhibitor of kappa B kinase, and NF kappa B, do not reduce amyloid beta 42 production

1 reference

7 January 2021

Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces Abeta 42 generation

1 reference

7 January 2021

Selected non-steroidal anti-inflammatory drugs and their derivatives target gamma-secretase at a novel site. Evidence for an allosteric mechanism.

1 reference

7 January 2021

Nonsteroidal anti-inflammatory drugs lower Abeta42 and change presenilin 1 conformation

1 reference

7 January 2021

Induction of the peroxisome proliferator activated receptor by fenofibrate in rat liver

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7 January 2021

Ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors

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7 January 2021

Biochemically based design of cyclooxygenase-2 (COX-2) inhibitors: facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors

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7 January 2021

Nonsteroidal Anti-Inflammatory Drugs Can Lower Amyloidogenic Aß 42 by Inhibiting Rho

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7 January 2021

Rho-kinase is involved in macrophage-mediated formation of coronary vascular lesions in pigs in vivo

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7 January 2021

Determination of GTP loading on Rho

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7 January 2021

Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors

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7 January 2021

Fenofibrate in the treatment of dyslipidemia: a review of the data as they relate to the new suprabioavailable tablet formulation

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7 January 2021

The four murine peroxisomal ABC-transporter genes differ in constitutive, inducible and developmental expression.

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7 January 2021

Dual mechanisms of ABCA1 regulation by geranylgeranyl pyrophosphate

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7 January 2021

New insights into the interaction of Ras with the plasma membrane

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7 January 2021

Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains

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7 January 2021

Squalene synthase inhibition alters metabolism of nonsterols in rat liver

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7 January 2021

Isoprenoids as mediators of the biological effects of statins

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7 January 2021

Statins inhibit HIV-1 infection by down-regulating Rho activity.

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7 January 2021

Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors.

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7 January 2021

Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons

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7 January 2021

A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease

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7 January 2021

Inflammation and Alzheimer's disease

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7 January 2021

Cyclooxygenase (COX)-2 and COX-1 Potentiate β-Amyloid Peptide Generation through Mechanisms That Involve γ-Secretase Activity

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7 January 2021

Cyclooxygenase-2 promotes amyloid plaque deposition in a mouse model of Alzheimer's disease neuropathology.

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7 January 2021

Clinical pharmacokinetics and pharmacodynamics of celecoxib: a selective cyclo-oxygenase-2 inhibitor

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Double placebo design in a prevention trial for Alzheimer's disease.

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7 January 2021

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7 January 2021

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7 January 2021

Presenilin 1 regulates pharmacologically distinct gamma -secretase activities. Implications for the role of presenilin in gamma -secretase cleavage

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7 January 2021

The profile of soluble amyloid beta protein in cultured cell media. Detection and quantification of amyloid beta protein and variants by immunoprecipitation-mass spectrometry

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7 January 2021

Inhibition of RhoA by p120 catenin

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7 January 2021

Cell-free assays for gamma-secretase activity

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7 January 2021

Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease.

1 reference

7 January 2021

Identifiers

DOI

10.1038/NM1235

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release_gckg5lir35citcfxpxnuilemeq

10 January 2020

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/gckg5lir35citcfxpxnuilemeq

24 November 2022

mapped directly with Wikidata item

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