Spotlight on BACE: the secretases as targets for treatment in Alzheimer disease (Q28363447)

Journal of Clinical Investigation

Europe PubMed Central

title

Spotlight on BACE: the secretases as targets for treatment in Alzheimer disease (English)

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C Dingwall

1

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language of work or name

English

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publication date

November 2001

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published in

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volume

108

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issue

9

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page(s)

1243-6

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cites work

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12 December 2020

Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease

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12 December 2020

The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation

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The carboxyl termini of beta-amyloid peptides 1-40 and 1-42 are generated by distinct gamma-secretase activities

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12 December 2020

Identifiers

DOI

10.1172/JCI14402

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1 reference

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PubMed publication ID

11696563

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