Anks4b, a novel target of HNF4α protein, interacts with GRP78 protein and regulates endoplasmic reticulum stress-induced apoptosis in pancreatic β-cells (Q28507247)

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Language	Label	Description	Also known as
English	Anks4b, a novel target of HNF4α protein, interacts with GRP78 protein and regulates endoplasmic reticulum stress-induced apoptosis in pancreatic β-cells	scientific journal article

Statements

scholarly article

1 reference

PubMed publication ID

24 January 2017

Anks4b, a novel target of HNF4α protein, interacts with GRP78 protein and regulates endoplasmic reticulum stress-induced apoptosis in pancreatic β-cells (English)

1 reference

PubMed publication ID

24 January 2017

endoplasmic reticulum

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apoptotic process

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Ankyrin repeat and sterile alpha motif domain containing 4B

1 reference

GOA release 2020-03-11

Hepatic nuclear factor 4, alpha

1 reference

GOA release 2020-03-11

HNF1 homeobox A

1 reference

GOA release 2020-03-11

Heat shock protein 5

1 reference

GOA release 2020-03-11

object named as

Mark A. Magnuson

7

0 references

5

object named as

Fan-Yan Wei

1 reference

PubMed publication ID

24 January 2017

Kazuhito Tomizawa

9

object named as

Kazuhito Tomizawa

1 reference

PubMed publication ID

24 January 2017

author name string

Yoshifumi Sato

1

1 reference

PubMed publication ID

24 January 2017

Mitsutoki Hatta

2

1 reference

PubMed publication ID

24 January 2017

Md Fazlul Karim

3

1 reference

PubMed publication ID

24 January 2017

Tomohiro Sawa

4

1 reference

PubMed publication ID

24 January 2017

Shoki Sato

6

1 reference

PubMed publication ID

24 January 2017

Frank J. Gonzalez

8

1 reference

PubMed publication ID

24 January 2017

Takaaki Akaike

10

1 reference

PubMed publication ID

24 January 2017

Tatsuya Yoshizawa

11

1 reference

PubMed publication ID

24 January 2017

Kazuya Yamagata

12

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PubMed publication ID

24 January 2017

language of work or name

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publication date

29 June 2012

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PubMed publication ID

24 January 2017

Journal of Biological Chemistry

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PubMed publication ID

24 January 2017

287

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PubMed publication ID

24 January 2017

27

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PubMed publication ID

24 January 2017

23236–23245

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PubMed publication ID

24 January 2017

Epistasis of transcriptomes reveals synergism between transcriptional activators Hnf1alpha and Hnf4alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3391104

19 March 2017

Macrosomia and hyperinsulinaemic hypoglycaemia in patients with heterozygous mutations in the HNF4A gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3391104

19 March 2017

The HNF-1 target collectrin controls insulin exocytosis by SNARE complex formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3391104

19 March 2017

The MODY1 gene HNF-4alpha regulates selected genes involved in insulin secretion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3391104

19 March 2017

Harp (harmonin-interacting, ankyrin repeat-containing protein), a novel protein that interacts with harmonin in epithelial tissues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3391104

19 March 2017

Co-operative regulation of the transcription of human dihydrodiol dehydrogenase (DD)4/aldo-keto reductase (AKR)1C4 gene by hepatocyte nuclear factor (HNF)-4alpha/gamma and HNF-1alpha

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3391104

19 March 2017

https://api.crossref.org/works/10.1074%2FJBC.M112.368779

21 January 2018

Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3391104

19 March 2017

Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3391104

19 March 2017

Mass Spectrometric Sequencing of Proteins from Silver-Stained Polyacrylamide Gels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3391104

19 March 2017

Hepatocyte nuclear factor 1 inactivation results in hepatic dysfunction, phenylketonuria, and renal Fanconi syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3391104

19 March 2017

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3391104

19 March 2017

Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3391104

19 March 2017

Cellular hypoxia of pancreatic beta-cells due to high levels of oxygen consumption for insulin secretion in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3391104

29 September 2017

Roles of GRP78 in physiology and cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3391104

29 September 2017

Integrated approach for the identification of human hepatocyte nuclear factor 4alpha target genes using protein binding microarrays

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3391104

29 September 2017

Regulation of hepatocyte nuclear factor 4 alpha-mediated transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3391104

29 September 2017

The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3391104

29 September 2017

Endoplasmic reticulum stress: signaling the unfolded protein response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3391104

29 September 2017

Expansion of adult beta-cell mass in response to increased metabolic demand is dependent on HNF-4alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3391104

29 September 2017

Functional characterization of the HNF4alpha isoform (HNF4alpha8) expressed in pancreatic beta-cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3391104

29 September 2017

Hepatocyte nuclear factor 4alpha enhances the hepatocyte nuclear factor 1alpha-mediated activation of transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3391104

29 September 2017

Retrovirus-mediated gene transfer and expression cloning: powerful tools in functional genomics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3391104

29 September 2017

Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3391104

29 September 2017

Diabetes mellitus and genetically programmed defects in beta-cell function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3391104

29 September 2017

R127W-HNF-4alpha is a loss of function mutation but not a rare polymorphism and causes Type II diabetes in a Japanese family with MODY1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3391104

29 September 2017

Mutation P291fsinsC in the transcription factor hepatocyte nuclear factor-1alpha is dominant negative

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3391104

29 September 2017

Signals from the stressed endoplasmic reticulum induce C/EBP-homologous protein (CHOP/GADD153).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3391104

29 September 2017

Hnf1alpha (MODY3) controls tissue-specific transcriptional programs and exerts opposed effects on cell growth in pancreatic islets and liver.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3391104

2 June 2018

Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3391104

2 June 2018

Establishment of a pancreatic beta cell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoforms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3391104

2 June 2018

Functional domains of the nuclear receptor hepatocyte nuclear factor 4.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.368779

21 January 2018

Hepatocyte nuclear factor-4alpha is essential for glucose-stimulated insulin secretion by pancreatic beta-cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.368779

21 January 2018

Role of the unfolded protein response regulator GRP78/BiP in development, cancer, and neurological disorders.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.368779

21 January 2018

A tool coming of age: thapsigargin as an inhibitor of sarco-endoplasmic reticulum Ca(2+)-ATPases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.368779

21 January 2018

Tmem27: a cleaved and shed plasma membrane protein that stimulates pancreatic beta cell proliferation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.368779

21 January 2018

Persistent hyperinsulinemic hypoglycemia and maturity-onset diabetes of the young due to heterozygous HNF4A mutations

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.368779

21 January 2018

Hepatocyte nuclear factor 4alpha regulates the expression of pancreatic beta -cell genes implicated in glucose metabolism and nutrient-induced insulin secretion

1 reference

https://pubmed.ncbi.nlm.nih.gov/22589549

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of HNF-4alpha (MODY1), HNF-1beta (MODY5), and HNF-1alpha (MODY3) proteins in the developing mouse pancreas

1 reference

https://pubmed.ncbi.nlm.nih.gov/22589549

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunoglobulin binding protein (BiP) function is required to protect cells from endoplasmic reticulum stress but is not required for the secretion of selective proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/22589549

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M112.368779

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PMC publication ID

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PubMed publication ID

1 reference

PubMed publication ID

24 January 2017

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