AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10 (Q28580635)

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English	AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10	scientific journal article

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scholarly article

1 reference

PubMed publication ID

31 January 2017

AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10 (English)

1 reference

PubMed publication ID

31 January 2017

transmembrane protein

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author name string

Matthew J. Ovens

1

1 reference

PubMed publication ID

31 January 2017

Andrew J. Davies

2

1 reference

PubMed publication ID

31 January 2017

Marieangela C. Wilson

3

1 reference

PubMed publication ID

31 January 2017

Clare M. Murray

4

1 reference

PubMed publication ID

31 January 2017

Andrew P. Halestrap

5

1 reference

PubMed publication ID

31 January 2017

language of work or name

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publication date

15 January 2010

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PubMed publication ID

31 January 2017

Biochemical Journal

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PubMed publication ID

31 January 2017

425

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PubMed publication ID

31 January 2017

3

1 reference

PubMed publication ID

31 January 2017

523–530

1 reference

PubMed publication ID

31 January 2017

copyright license

Creative Commons Attribution-NonCommercial 2.5 Generic

25 July 2019

1 reference

April 2022 Public Data File from Crossref

copyright status

0 references

Studies on the DIDS-binding site of monocarboxylate transporter 1 suggest a homology model of the open conformation and a plausible translocation cycle

1 reference

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17 March 2017

The role of charged residues in the transmembrane helices of monocarboxylate transporter 1 and its ancillary protein basigin in determining plasma membrane expression and catalytic activity

1 reference

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17 March 2017

Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70)

1 reference

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17 March 2017

Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter

1 reference

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The SLC16 gene family?from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond

1 reference

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Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle

1 reference

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17 March 2017

CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811425

17 March 2017

The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation

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17 March 2017

Cloning of the monocarboxylate transporter isoform MCT2 from rat testis provides evidence that expression in tissues is species-specific and may involve post-transcriptional regulation

1 reference

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17 March 2017

Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle

1 reference

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Specific inhibition of pyruvate transport in rat liver mitochondria and human erythrocytes by alpha-cyano-4-hydroxycinnamate

1 reference

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cDNA cloning of MEV, a mutant protein that facilitates cellular uptake of mevalonate, and identification of the point mutation responsible for its gain of function

1 reference

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The mitochondrial pyruvate carrier. Kinetics and specificity for substrates and inhibitors

1 reference

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Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice

1 reference

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24 May 2017

Inhibition of monocarboxylate transporter 2 in the retrotrapezoid nucleus in rats: a test of the astrocyte-neuron lactate-shuttle hypothesis

1 reference

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29 September 2017

The specific monocarboxylate transporter-1 (MCT-1) inhibitor, AR-C117977, induces donor-specific suppression, reducing acute and chronic allograft rejection in the rat.

1 reference

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Is lactate food for neurons? Comparison of monocarboxylate transporter subtypes in brain and muscle.

1 reference

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29 September 2017

The H+-linked monocarboxylate transporter (MCT1/SLC16A1): a potential therapeutic target for high-risk neuroblastoma

1 reference

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The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism.

1 reference

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Monocarboxylate transporter MCT1 is a target for immunosuppression

1 reference

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Monocarboxylate transporters in the central nervous system: distribution, regulation and function.

1 reference

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29 September 2017

Lactate transport in skeletal muscle - role and regulation of the monocarboxylate transporter.

1 reference

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29 September 2017

Lactate transport in heart in relation to myocardial ischemia

1 reference

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29 September 2017

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811425

29 September 2017

Transport of lactate and other monocarboxylates across mammalian plasma membranes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811425

29 September 2017

cDNA cloning of MCT2, a second monocarboxylate transporter expressed in different cells than MCT1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811425

29 September 2017

Facilitated diffusion of glucose

1 reference

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1 reference

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Mouse MCT3 gene is expressed preferentially in retinal pigment and choroid plexus epithelia

1 reference

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Characterization of the monocarboxylate transporter 1 expressed in Xenopus laevis oocytes by changes in cytosolic pH.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811425

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Studies of the membrane topology of the rat erythrocyte H+/lactate cotransporter (MCT1).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811425

3 June 2018

N-terminal protein sequence analysis of the rabbit erythrocyte lactate transporter suggests identity with the cloned monocarboxylate transport protein MCT1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811425

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1 reference

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1 reference

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1 reference

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811425

3 June 2018

Reversible and irreversible inhibition, by stilbenedisulphonates, of lactate transport into rat erythrocytes. Identification of some new high-affinity inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811425

3 June 2018

Transport of pyruvate nad lactate into human erythrocytes. Evidence for the involvement of the chloride carrier and a chloride-independent carrier

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811425

3 June 2018

Characterization of the high-affinity monocarboxylate transporter MCT2 in Xenopus laevis oocytes

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091515

21 January 2018

Determination of transport kinetics of chick MCT3 monocarboxylate transporter from retinal pigment epithelium by expression in genetically modified yeast

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091515

21 January 2018

The low-affinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091515

21 January 2018

Lactic acid efflux from white skeletal muscle is catalyzed by the monocarboxylate transporter isoform MCT3.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091515

21 January 2018

Potent blockers of the monocarboxylate transporter MCT1: novel immunomodulatory compounds.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091515

21 January 2018

Swelling-induced taurine release without chloride channel activity in Xenopus laevis oocytes expressing anion channels and transporters

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091515

21 January 2018

Metabolic effects of blocking lactate transport in brain cortical tissue slices using an inhibitor specific to MCT1 and MCT2.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091515

21 January 2018

Kinetics of GLUT1 and GLUT4 glucose transporters expressed in Xenopus oocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811425

27 November 2018

The SLC16 monocaboxylate transporter family

1 reference

https://pubmed.ncbi.nlm.nih.gov/19929853

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discrimination of three parallel pathways of lactate transport in the human erythrocyte membrane by inhibitors and kinetic properties

1 reference

https://pubmed.ncbi.nlm.nih.gov/19929853

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of the lactate transporter (MCT1) in skeletal muscles

1 reference

https://pubmed.ncbi.nlm.nih.gov/19929853

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Optimization of monocarboxylate transporter 1 blockers through analysis and modulation of atropisomer interconversion properties

1 reference

https://pubmed.ncbi.nlm.nih.gov/19929853

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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