Huntingtin interacting protein 1 (Q21111483)

http://www.ebi.ac.uk/interpro/protein/O00291

Huntingtin-interacting protein 1

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O00291

I/LWEQ domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O00291

I/LWEQ domain, protein family

1 reference

Huntingtin-interacting protein 1, clathrin-binding domain, protein family

1 reference

AP180 N-terminal homology (ANTH) domain, protein family

1 reference

ENTH domain, protein family

1 reference

1 reference

13 November 2019

1 reference

13 November 2019

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00291&geneProductId=UniProtKB:O00291

4 references

16 July 2018

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00291&geneProductId=UniProtKB:O00291

16 July 2018

HIP1 and HIP1r stabilize receptor tyrosine kinases and bind 3-phosphoinositides via epsin N-terminal homology domains

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00291&geneProductId=UniProtKB:O00291

16 July 2018

Clathrin- and AP-2-binding sites in HIP1 uncover a general assembly role for endocytic accessory proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00291&geneProductId=UniProtKB:O00291

structural constituent of cytoskeleton

1 reference

8 April 2019

HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

protein binding

12 references

8 April 2019

Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

8 April 2019

HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

8 April 2019

HIP1 and HIP12 display differential binding to F-actin, AP2, and clathrin. Identification of a novel interaction with clathrin light chain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

8 April 2019

Huntingtin interacting protein 1 modulates the transcriptional activity of nuclear hormone receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

8 April 2019

Huntingtin-interacting protein 1-mediated neuronal cell death occurs through intrinsic apoptotic pathways and mitochondrial alterations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

8 April 2019

Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

8 April 2019

A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

8 April 2019

A human interactome in three quantitative dimensions organized by stoichiometries and abundances

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

8 April 2019

A proteome-scale map of the human interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

8 April 2019

Replacement of charged and polar residues in the coiled-coiled interface of huntingtin-interacting protein 1 (HIP1) causes aggregation and cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

8 April 2019

Huntingtin interacting proteins are genetic modifiers of neurodegeneration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

8 April 2019

The NECAP PHear domain increases clathrin accessory protein binding potential

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

phospholipid binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

1 reference

8 April 2019

epidermal growth factor receptor binding

1 reference

8 April 2019

The Sla2p/HIP1/HIP1R family: similar structure, similar function in endocytosis?

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

phosphatidylinositol-4,5-bisphosphate binding

1 reference

8 April 2019

HIP1 and HIP1r stabilize receptor tyrosine kinases and bind 3-phosphoinositides via epsin N-terminal homology domains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

clathrin light chain binding

2 references

16 July 2018

Actin binding by Hip1 (huntingtin-interacting protein 1) and Hip1R (Hip1-related protein) is regulated by clathrin light chain

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00291&geneProductId=UniProtKB:O00291

16 July 2018

Huntingtin-interacting protein 1 (Hip1) and Hip1-related protein (Hip1R) bind the conserved sequence of clathrin light chains and thereby influence clathrin assembly in vitro and actin distribution in vivo

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00291&geneProductId=UniProtKB:O00291

phosphatidylinositol-3-phosphate binding

1 reference

8 April 2019

HIP1 and HIP1r stabilize receptor tyrosine kinases and bind 3-phosphoinositides via epsin N-terminal homology domains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

glutamate receptor binding

1 reference

8 April 2019

The Sla2p/HIP1/HIP1R family: similar structure, similar function in endocytosis?

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

AP-2 adaptor complex binding

1 reference

8 April 2019

Huntingtin-interacting protein 1 (Hip1) and Hip1-related protein (Hip1R) bind the conserved sequence of clathrin light chains and thereby influence clathrin assembly in vitro and actin distribution in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

clathrin adaptor activity

1 reference

16 July 2018

Actin binding by Hip1 (huntingtin-interacting protein 1) and Hip1R (Hip1-related protein) is regulated by clathrin light chain

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00291&geneProductId=UniProtKB:O00291

protein homodimerization activity

2 references

8 April 2019

Actin binding by Hip1 (huntingtin-interacting protein 1) and Hip1R (Hip1-related protein) is regulated by clathrin light chain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

8 April 2019

Huntingtin-interacting protein 1 (Hip1) and Hip1-related protein (Hip1R) bind the conserved sequence of clathrin light chains and thereby influence clathrin assembly in vitro and actin distribution in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

phosphatidylinositol-3,4-bisphosphate binding

1 reference

16 July 2018

HIP1 and HIP1r stabilize receptor tyrosine kinases and bind 3-phosphoinositides via epsin N-terminal homology domains

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00291&geneProductId=UniProtKB:O00291

protein heterodimerization activity

1 reference

8 April 2019

Huntingtin-interacting protein 1 (Hip1) and Hip1-related protein (Hip1R) bind the conserved sequence of clathrin light chains and thereby influence clathrin assembly in vitro and actin distribution in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

actin filament binding

1 reference

16 July 2018

Actin binding by Hip1 (huntingtin-interacting protein 1) and Hip1R (Hip1-related protein) is regulated by clathrin light chain

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00291&geneProductId=UniProtKB:O00291

phosphatidylinositol-3,5-bisphosphate binding

1 reference

16 July 2018

HIP1 and HIP1r stabilize receptor tyrosine kinases and bind 3-phosphoinositides via epsin N-terminal homology domains

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00291&geneProductId=UniProtKB:O00291

clathrin binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

5 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

8 April 2019

HIP1 and HIP1r stabilize receptor tyrosine kinases and bind 3-phosphoinositides via epsin N-terminal homology domains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

8 April 2019

Clathrin- and AP-2-binding sites in HIP1 uncover a general assembly role for endocytic accessory proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

clathrin light chain binding

Actin binding by Hip1 (huntingtin-interacting protein 1) and Hip1R (Hip1-related protein) is regulated by clathrin light chain

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

8 April 2019

Huntingtin-interacting protein 1 (Hip1) and Hip1-related protein (Hip1R) bind the conserved sequence of clathrin light chains and thereby influence clathrin assembly in vitro and actin distribution in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

phosphatidylinositol binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

3 references

8 April 2019

8 April 2019

HIP1 and HIP1r stabilize receptor tyrosine kinases and bind 3-phosphoinositides via epsin N-terminal homology domains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

clathrin adaptor activity

phosphatidylinositol-3,4-bisphosphate binding

actin filament binding

phosphatidylinositol-3,5-bisphosphate binding

HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain

3 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00291&geneProductId=UniProtKB:O00291

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00291&geneProductId=UniProtKB:O00291

16 July 2018

16 July 2018

Huntingtin interacting protein 1 Is a clathrin coat binding protein required for differentiation of late spermatogenic progenitors

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00291&geneProductId=UniProtKB:O00291

Golgi apparatus

1 reference

8 April 2019

Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

intracellular membrane-bounded organelle

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00291&geneProductId=UniProtKB:O00291

1 reference

16 July 2018

clathrin-coated vesicle membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

1 reference

8 April 2019

cytoskeleton

1 reference

8 April 2019

HIP-I: a huntingtin interacting protein isolated by the yeast two-hybrid system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

cytoplasmic vesicle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

1 reference

8 April 2019

endomembrane system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

1 reference

8 April 2019

clathrin-coated vesicle

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00291&geneProductId=UniProtKB:O00291

3 references

16 July 2018

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00291&geneProductId=UniProtKB:O00291

16 July 2018

HIP1 functions in clathrin-mediated endocytosis through binding to clathrin and adaptor protein 2

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00291&geneProductId=UniProtKB:O00291

cytosol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

1 reference

8 April 2019

AP-2 adaptor complex

1 reference

16 July 2018

HIP1 and HIP1r stabilize receptor tyrosine kinases and bind 3-phosphoinositides via epsin N-terminal homology domains

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00291&geneProductId=UniProtKB:O00291

extrinsic component of cytoplasmic side of plasma membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

extrinsic component of presynaptic membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

extrinsic component of postsynaptic membrane

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00291&geneProductId=UniProtKB:O00291

postsynaptic membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

glutamatergic synapse

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

cytoplasm

HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

8 April 2019

8 April 2019

Huntingtin interacting protein 1 Is a clathrin coat binding protein required for differentiation of late spermatogenic progenitors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

AP-2 adaptor complex

clathrin-coated vesicle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

4 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

8 April 2019

HIP1 functions in clathrin-mediated endocytosis through binding to clathrin and adaptor protein 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

actin cortical patch

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

presynapse

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

8 April 2019

The Sla2p/HIP1/HIP1R family: similar structure, similar function in endocytosis?

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

regulation of apoptotic process

biological process

1 reference

8 April 2019

Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

1 reference

8 April 2019

positive regulation of receptor-mediated endocytosis

Clathrin- and AP-2-binding sites in HIP1 uncover a general assembly role for endocytic accessory proteins

3 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00291&geneProductId=UniProtKB:O00291

16 July 2018

The huntingtin interacting protein HIP1 is a clathrin and alpha-adaptin-binding protein involved in receptor-mediated endocytosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00291&geneProductId=UniProtKB:O00291

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00291&geneProductId=UniProtKB:O00291

regulation of transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00291&geneProductId=UniProtKB:O00291

1 reference

16 July 2018

endocytosis

transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00291&geneProductId=UniProtKB:O00291

1 reference

16 July 2018

clathrin-dependent endocytosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

1 reference

8 April 2019

clathrin coat assembly

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00291&geneProductId=UniProtKB:O00291

4 references

16 July 2018

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00291&geneProductId=UniProtKB:O00291

16 July 2018

HIP1 and HIP12 display differential binding to F-actin, AP2, and clathrin. Identification of a novel interaction with clathrin light chain

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00291&geneProductId=UniProtKB:O00291

16 July 2018

Clathrin- and AP-2-binding sites in HIP1 uncover a general assembly role for endocytic accessory proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00291&geneProductId=UniProtKB:O00291

apoptotic signaling pathway

1 reference

8 April 2019

Huntingtin interacting protein 1 induces apoptosis via a novel caspase-dependent death effector domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

activation of cysteine-type endopeptidase activity involved in apoptotic process

1 reference

16 July 2018

Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00291&geneProductId=UniProtKB:O00291

apoptotic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

8 April 2019

8 April 2019

Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

cytoskeleton organization

1 reference

16 July 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00291&geneProductId=UniProtKB:O00291

regulation of endocytosis

NAS

1 reference

8 April 2019

The Sla2p/HIP1/HIP1R family: similar structure, similar function in endocytosis?

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

positive regulation of epidermal growth factor receptor signaling pathway

NAS

1 reference

8 April 2019

HIP1 and HIP1r stabilize receptor tyrosine kinases and bind 3-phosphoinositides via epsin N-terminal homology domains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

protein stabilization

1 reference

8 April 2019

HIP1 and HIP1r stabilize receptor tyrosine kinases and bind 3-phosphoinositides via epsin N-terminal homology domains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

positive regulation of protein kinase B signaling

1 reference

8 April 2019

HIP1 and HIP1r stabilize receptor tyrosine kinases and bind 3-phosphoinositides via epsin N-terminal homology domains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

membrane organization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

1 reference

8 April 2019

neurotransmitter receptor transport

1 reference

8 April 2019

The Sla2p/HIP1/HIP1R family: similar structure, similar function in endocytosis?

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

positive regulation of platelet-derived growth factor receptor-beta signaling pathway

1 reference

8 April 2019

HIP1 and HIP1r stabilize receptor tyrosine kinases and bind 3-phosphoinositides via epsin N-terminal homology domains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

activation of cysteine-type endopeptidase activity involved in apoptotic process

actin filament organization

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

positive regulation of receptor-mediated endocytosis

The huntingtin interacting protein HIP1 is a clathrin and alpha-adaptin-binding protein involved in receptor-mediated endocytosis

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

8 April 2019

Clathrin- and AP-2-binding sites in HIP1 uncover a general assembly role for endocytic accessory proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

clathrin coat assembly

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

5 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

8 April 2019

HIP1 and HIP12 display differential binding to F-actin, AP2, and clathrin. Identification of a novel interaction with clathrin light chain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

8 April 2019

Clathrin- and AP-2-binding sites in HIP1 uncover a general assembly role for endocytic accessory proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291