Pyruvate dehydrogenase kinase as a novel therapeutic target in oncology (Q21129303)

PubMed publication ID

23471124

16 August 2022

Evangelos D Michelakis

series ordinal

2

author given names

Evangelos D

author last names

Michelakis

1 reference

PubMed publication ID

23471124

16 August 2022

language of work or name

English

0 references

publication date

2013

0 references

published in

Frontiers in Oncology

1 reference

Inactivation of the HIF-1α/PDK3 signaling axis drives melanoma toward mitochondrial oxidative metabolism and potentiates the therapeutic activity of pro-oxidants

Crossref

volume

3

0 references

page(s)

38

0 references

cites work

1 reference

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p53 negatively regulates transcription of the pyruvate dehydrogenase kinase Pdk2

19 March 2017

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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

19 March 2017

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Understanding the Warburg effect: the metabolic requirements of cell proliferation

19 March 2017

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Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer

19 March 2017

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Pyruvate dehydrogenase complex activity controls metabolic and malignant phenotype in cancer cells

19 March 2017

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19 March 2017

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Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells

19 March 2017

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Regulatory roles of the N-terminal domain based on crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands

19 March 2017

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Reactive oxygen species-induced phosphorylation of p53 on serine 20 is mediated in part by polo-like kinase-3

19 March 2017

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The role of hydroxyl radical as a messenger in Cr(VI)-induced p53 activation

19 March 2017

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Vanadate induces p53 transactivation through hydrogen peroxide and causes apoptosis

19 March 2017

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Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha

19 March 2017

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Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex

19 March 2017

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Glucose catabolism in cancer cells. The type II hexokinase promoter contains functionally active response elements for the tumor suppressor p53

19 March 2017

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Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

19 March 2017

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19 March 2017

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Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

19 March 2017

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Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.

19 March 2017

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On the Origin of Cancer Cells

19 March 2017

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19 March 2017

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Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

12 September 2017

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TIGAR, a p53-inducible regulator of glycolysis and apoptosis

19 March 2017

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Mitochondrial activation by inhibition of PDKII suppresses HIF1a signaling and angiogenesis in cancer

19 March 2017

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Metabolic modulation of glioblastoma with dichloroacetate

19 March 2017

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Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion

19 March 2017

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A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth

19 March 2017

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p53 regulates mitochondrial respiration

19 March 2017

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Controlled clinical trial of dichloroacetate for treatment of congenital lactic acidosis in children

19 March 2017

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HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

19 March 2017

1 reference

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Dichloroacetate causes toxic neuropathy in MELAS: a randomized, controlled clinical trial

19 March 2017

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NFAT proteins: key regulators of T-cell development and function

19 March 2017

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Glycolytic enzymes can modulate cellular life span

19 March 2017

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Why do cancers have high aerobic glycolysis?

19 March 2017

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Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase

19 March 2017

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Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

19 March 2017

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Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit

19 March 2017

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The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted

19 March 2017

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Mitochondrial Membrane Potential in Living Cells

19 March 2017

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The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

6 April 2017

1 reference

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Mitochondrial membrane permeabilization in cell death

7 April 2017

1 reference

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The pathophysiology of mitochondrial cell death

7 April 2017

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7 April 2017

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Mitofusin 2 tethers endoplasmic reticulum to mitochondria

7 April 2017

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Malignant gliomas in adults

7 April 2017

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Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance

7 April 2017

1 reference

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Akt stimulates aerobic glycolysis in cancer cells

7 April 2017

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Regulation of angiogenesis by hypoxia: role of the HIF system

7 April 2017

1 reference

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The mitochondrial permeability transition pore and its role in cell death

7 April 2017

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Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining

7 April 2017

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Curbing cancer's sweet tooth: is there a role for MnSOD in regulation of the Warburg effect?

7 April 2017

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Novel molecular mechanisms of antitumor action of dichloroacetate against T cell lymphoma: Implication of altered glucose metabolism, pH homeostasis and cell survival regulation

12 September 2017

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New aspects of mitochondrial Uncoupling Proteins (UCPs) and their roles in tumorigenesis

12 September 2017

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Evidence for an alternative glycolytic pathway in rapidly proliferating cells

12 September 2017

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The role of mitochondria in pulmonary vascular remodeling

12 September 2017

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Dichloroacetate induces apoptosis and cell-cycle arrest in colorectal cancer cells

12 September 2017

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Reactive oxygen species: A radical role in development?

12 September 2017

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Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction

12 September 2017

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12 September 2017

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CPEB regulation of human cellular senescence, energy metabolism, and p53 mRNA translation

12 September 2017

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12 September 2017

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Mitochondrial depolarization and the role of uncoupling proteins in ischemia tolerance

12 September 2017

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Acute oxygen-sensing mechanisms

12 September 2017

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Multifaceted roles of glycolytic enzymes.

12 September 2017

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PACS-2 controls endoplasmic reticulum-mitochondria communication and Bid-mediated apoptosis

12 September 2017

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PI3K-Akt pathway: its functions and alterations in human cancer

12 September 2017

1 reference

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DNA damage is a prerequisite for p53-mediated proteasomal degradation of HIF-1alpha in hypoxic cells and downregulation of the hypoxia marker carbonic anhydrase IX.

12 September 2017

1 reference

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Activation of K+ channels: an essential pathway in programmed cell death

12 September 2017

1 reference

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Anaplerotic reactions in tumour proliferation and apoptosis

12 September 2017

1 reference

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Hexokinase II: the integration of energy metabolism and control of apoptosis

12 September 2017

1 reference

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Efficacy of dichloroacetate as a lactate-lowering drug

12 September 2017

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Cisplatin biochemical mechanism of action: from cytotoxicity to induction of cell death through interconnections between apoptotic and necrotic pathways

12 September 2017

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The mitochondrion in apoptosis: how Pandora's box opens

12 September 2017

1 reference

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Uncoupling proteins 2 and 3: potential regulators of mitochondrial energy metabolism.

12 September 2017

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Regulatory interactions between lipids and carbohydrates: the glucose fatty acid cycle after 35 years.

12 September 2017

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Contributions of mitochondria to animal physiology: from homeostatic sensor to calcium signalling and cell death

12 September 2017

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The pharmacology of dichloroacetate

12 September 2017

1 reference

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Reversal of the glycolytic phenotype by dichloroacetate inhibits metastatic breast cancer cell growth in vitro and in vivo

12 September 2017

1 reference

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Dichloroacetate (DCA) sensitizes both wild-type and over expressing Bcl-2 prostate cancer cells in vitro to radiation

27 September 2017

1 reference

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p300 relieves p53-evoked transcriptional repression of hypoxia-inducible factor-1 (HIF-1).

27 September 2017

1 reference

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Identification of seven genes regulated by wild-type p53 in a colon cancer cell line carrying a well-controlled wild-type p53 expression system

27 September 2017

1 reference

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The permeability transition pore. Control points of a cyclosporin A-sensitive mitochondrial channel involved in cell death

27 September 2017

1 reference

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Review of the pharmacologic and therapeutic effects of diisopropylammonium dichloroacetate (DIPA)

27 September 2017

1 reference

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Effect of altered redox states on expression and DNA-binding activity of hypoxia-inducible factor 1.

27 September 2017

1 reference

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The role of Nogo and the mitochondria-endoplasmic reticulum unit in pulmonary hypertension

27 September 2017

1 reference

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Metabolic enzymes as oncogenes or tumor suppressors

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3590642

VDAC-dependent permeabilization of the outer mitochondrial membrane by superoxide induces rapid and massive cytochrome c release

30 May 2018

1 reference

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Selection of cancer cells with repressed mitochondria triggers colon cancer progression

30 May 2018

1 reference

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Expression of HIF-1alpha in injured arteries controls SDF-1alpha mediated neointima formation in apolipoprotein E deficient mice.

29 November 2018

1 reference

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Why is cancer drug discovery so difficult?

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3590642

Regulation of the multidrug resistance transporter P-glycoprotein in multicellular tumor spheroids by hypoxia-inducible factor (HIF-1) and reactive oxygen species

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3590642

Glucose catabolism in cancer cells: identification and characterization of a marked activation response of the type II hexokinase gene to hypoxic conditions

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3590642

From the molecule to the clinic--inhibiting HER2 to treat breast cancer

29 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/23471124

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Activation of glycogen synthase kinase 3beta disrupts the binding of hexokinase II to mitochondria by phosphorylating voltage-dependent anion channel and potentiates chemotherapy-induced cytotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/23471124

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.3389/FONC.2013.00038

1 reference

1 reference

1 reference

PubMed publication ID

23471124

1 reference