p21(WAF1/Cip1): more than a break to the cell cycle? (Q34020123)

30 July 2017

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title

p21(WAF1/Cip1): more than a break to the cell cycle? (English)

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DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator

30 July 2017

main subject

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Gene Ontology release 2020-05-02

G P Dotto

1

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30 July 2017

language of work or name

English

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publication date

1 July 2000

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Biochimica et Biophysica Acta

30 July 2017

published in

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30 July 2017

volume

1471

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30 July 2017

issue

1

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30 July 2017

page(s)

M43-56

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The cell as a collection of protein machines: preparing the next generation of molecular biologists

30 July 2017

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WAF1, a potential mediator of p53 tumor suppression

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7 January 2021

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

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7 January 2021

Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen

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7 January 2021

CDK inhibitors: positive and negative regulators of G1-phase progression

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7 January 2021

Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair.

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7 January 2021

Cip1 inhibits DNA replication but not PCNA-dependent nucleotide excision-repair

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7 January 2021

Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA.

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7 January 2021

Cell-cycle inhibition by independent CDK and PCNA binding domains in p21Cip1

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7 January 2021

Reversible phosphorylation at the C-terminal regulatory domain of p21(Waf1/Cip1) modulates proliferating cell nuclear antigen binding

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7 January 2021

Suppression of cell transformation by the cyclin-dependent kinase inhibitor p57KIP2 requires binding to proliferating cell nuclear antigen

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7 January 2021

Cyclin-binding motifs are essential for the function of p21CIP1

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7 January 2021

p21CIP1 and Cdc25A: competition between an inhibitor and an activator of cyclin-dependent kinases

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7 January 2021

p21 Disrupts the interaction between cdk2 and the E2F-p130 complex

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7 January 2021

Control of E2F activity by p21Waf1/Cip1

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7 January 2021

Inhibitory function of p21Cip1/WAF1 in differentiation of primary mouse keratinocytes independent of cell cycle control

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7 January 2021

Reciprocal regulation via protein-protein interaction between c-Myc and p21(cip1/waf1/sdi1) in DNA replication and transcription

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7 January 2021

Regulation of NF-kappaB by cyclin-dependent kinases associated with the p300 coactivator

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7 January 2021

A novel transcriptional repression domain mediates p21(WAF1/CIP1) induction of p300 transactivation

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7 January 2021

Effects of p21Waf1/Cip1/Sdi1 on cellular gene expression: implications for carcinogenesis, senescence, and age-related diseases

1 reference

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7 January 2021

Inhibition of CDK activity and PCNA-dependent DNA replication by p21 is blocked by interaction with the HPV-16 E7 oncoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900019-6

7 January 2021

The human papillomavirus E7 oncoprotein can uncouple cellular differentiation and proliferation in human keratinocytes by abrogating p21Cip1-mediated inhibition of cdk2.

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7 January 2021

p21-containing cyclin kinases exist in both active and inactive states

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7 January 2021

Functional analysis of a p21WAF1,CIP1,SDI1 mutant (Arg94 --> Trp) identified in a human breast carcinoma. Evidence that the mutation impairs the ability of p21 to inhibit cyclin-dependent kinases.

1 reference

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7 January 2021

Protein-PCNA interactions: a DNA-scanning mechanism?

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7 January 2021

Purification of PCNA as a nucleotide excision repair protein

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https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900019-6

7 January 2021

Inhibition of Nucleotide Excision Repair by the Cyclin-dependent Kinase Inhibitor p21

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https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900019-6

7 January 2021

Mechanism of inhibition of proliferating cell nuclear antigen-dependent DNA synthesis by the cyclin-dependent kinase inhibitor p21.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900019-6

7 January 2021

Homologous regions of Fen1 and p21Cip1 compete for binding to the same site on PCNA: a potential mechanism to co-ordinate DNA replication and repair

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900019-6

7 January 2021

Human DNA-(Cytosine-5) Methyltransferase-PCNA Complex as a Target for p21WAF1

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7 January 2021

A 5' to 3' exonuclease functionally interacts with calf DNA polymerase epsilon

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7 January 2021

Lagging Strand DNA Synthesis at the Eukaryotic Replication Fork Involves Binding and Stimulation of FEN-1 by Proliferating Cell Nuclear Antigen

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7 January 2021

Processing of branched DNA intermediates by a complex of human FEN-1 and PCNA.

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7 January 2021

Structure of the C-terminal region of p21(WAF1/CIP1) complexed with human PCNA

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7 January 2021

Mammalian genes induced by radiation; activation of genes associated with growth control.

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7 January 2021

Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen

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7 January 2021

Genomic instability in Gadd45a-deficient mice

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7 January 2021

A small peptide inhibitor of DNA replication defines the site of interaction between the cyclin-dependent kinase inhibitor p21WAF1 and proliferating cell nuclear antigen

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7 January 2021

A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK

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7 January 2021

A non-enzymatic p21 protein inhibitor of stress-activated protein kinases

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7 January 2021

Apoptosis inhibitory activity of cytoplasmic p21(Cip1/WAF1) in monocytic differentiation

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7 January 2021

The proto-oncogene Bcl-2 and its role in regulating apoptosis

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7 January 2021

Biochemical pathways of caspase activation during apoptosis

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7 January 2021

Stress signals for apoptosis: ceramide and c-Jun kinase

1 reference

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7 January 2021

Resistance to Fas-mediated apoptosis: activation of caspase 3 is regulated by cell cycle regulator p21WAF1 and IAP gene family ILP

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900019-6

7 January 2021

Caspase 3 inactivation to suppress Fas-mediated apoptosis: identification of binding domain with p21 and ILP and inactivation machinery by p21

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900019-6

7 January 2021

Mitochondrial regulation of cell death: mitochondria are essential for procaspase 3-p21 complex formation to resist Fas-mediated cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900019-6

7 January 2021

Cleavage of p21Cip1/Waf1 and p27Kip1 mediates apoptosis in endothelial cells through activation of Cdk2: role of a caspase cascade

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900019-6

7 January 2021

Caspase 3 specifically cleaves p21WAF1/CIP1 in the earlier stage of apoptosis in SK-HEP-1 human hepatoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900019-6

7 January 2021

Cleavage of CDK inhibitor p21(Cip1/Waf1) by caspases is an early event during DNA damage-induced apoptosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900019-6

7 January 2021

Caspase-mediated cleavage of p21Waf1/Cip1 converts cancer cells from growth arrest to undergoing apoptosis

1 reference

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7 January 2021

Signal transduction by the c-Jun N-terminal kinase (JNK)--from inflammation to development

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7 January 2021

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

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7 January 2021

Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways

1 reference

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7 January 2021

Requirement of Rsk-2 for epidermal growth factor-activated phosphorylation of histone H3

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7 January 2021

The nucleosomal response associated with immediate-early gene induction is mediated via alternative MAP kinase cascades: MSK1 as a potential histone H3/HMG-14 kinase

1 reference

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7 January 2021

Calmodulin binds to p21(Cip1) and is involved in the regulation of its nuclear localization

1 reference

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7 January 2021

The Protein SET Regulates the Inhibitory Effect of p21Cip1on Cyclin E-Cyclin-dependent Kinase 2 Activity

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7 January 2021

CCAAT/enhancer binding protein alpha regulates p21 protein and hepatocyte proliferation in newborn mice

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7 January 2021

CK2: a protein kinase in need of control.

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7 January 2021

The p53 tumour suppressor protein is phosphorylated at serine 389 by casein kinase II.

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7 January 2021

Activation of the cryptic DNA binding function of mutant forms of p53.

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7 January 2021

Biosynthesis of casein kinase II in lymphoid cell lines

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7 January 2021

Calmodulin and calmodulin-binding proteins in the nucleus

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7 January 2021

Calmodulin regulates DNA polymerase alpha activity during proliferative activation of NRK cells

1 reference

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7 January 2021

CaMK-II inhibition reduces cyclin D1 levels and enhances the association of p27kip1 with Cdk2 to cause G1 arrest in NIH 3T3 cells

1 reference

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7 January 2021

Calcineurin is essential for DNA synthesis in Swiss 3T3 fibroblasts

1 reference

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7 January 2021

Calmodulin is essential for cyclin-dependent kinase 4 (Cdk4) activity and nuclear accumulation of cyclin D1-Cdk4 during G1

1 reference

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7 January 2021

New functional activities for the p21 family of CDK inhibitors

1 reference

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7 January 2021

Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3' half to different genes: characterization of the set gene

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7 January 2021

Replication factor encoded by a putative oncogene, set, associated with myeloid leukemogenesis

1 reference

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7 January 2021

The myeloid leukemia-associated protein SET is a potent inhibitor of protein phosphatase 2A

1 reference

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7 January 2021

Members of the NAP/SET family of proteins interact specifically with B-type cyclins

1 reference

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7 January 2021

CCAAT/enhancer-binding protein alpha (C/EBP alpha) inhibits cell proliferation through the p21 (WAF-1/CIP-1/SDI-1) protein

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7 January 2021

Radiation-induced cell cycle arrest compromised by p21 deficiency

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7 January 2021

Inhibition of cyclin-dependent kinase 2 by p21 is necessary for retinoblastoma protein-mediated G1 arrest after gamma-irradiation

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7 January 2021

Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21

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7 January 2021

Requirement for p53 and p21 to sustain G2 arrest after DNA damage

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7 January 2021

Transcriptional Regulation of the p21(WAF1/CIP1)Gene

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7 January 2021

Genetic determinants of p53-induced apoptosis and growth arrest

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7 January 2021

Protective role of p21(Waf1/Cip1) against prostaglandin A2-mediated apoptosis of human colorectal carcinoma cells

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7 January 2021

The cyclin-dependent kinase inhibitor p21 (WAF1) is required for survival of differentiating neuroblastoma cells

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7 January 2021

Cancer dormancy and cell signaling: induction of p21(waf1) initiated by membrane IgM engagement increases survival of B lymphoma cells

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7 January 2021

Commitment and effector phases of the physiological cell death pathway elucidated with respect to Bcl-2 caspase, and cyclin-dependent kinase activities

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7 January 2021

Caspase-dependent activation of cyclin-dependent kinases during Fas-induced apoptosis in Jurkat cells

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7 January 2021

The cyclin-dependent kinase Cdk2 regulates thymocyte apoptosis

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7 January 2021

Caspase-dependent Cdk activity is a requisite effector of apoptotic death events

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7 January 2021

p21(WAF1/CIP1) inhibits initiator caspase cleavage by TRAIL death receptor DR4.

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7 January 2021

p21 (WAF1/CIP1) expression is induced in newly nondividing cells in diverse epithelia and during differentiation of the Caco-2 intestinal cell line.

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7 January 2021

Ultraviolet Light Induces Expression of p53 and p21 in Human Skin: Effect of Sunscreen and Constitutive p21 Expression in Skin Appendages

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7 January 2021

A function of p21 during promyelocytic leukemia cell differentiation independent of CDK inhibition and cell cycle arrest

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7 January 2021

p21(CIP1) and p57(KIP2) control muscle differentiation at the myogenin step

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7 January 2021

Caspase activation in the terminal differentiation of human epidermal keratinocytes

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7 January 2021

Signal transduction pathways controlling the switch between keratinocyte growth and differentiation

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7 January 2021

The role of Far1p in linking the heterotrimeric G protein to polarity establishment proteins during yeast mating

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7 January 2021

p21(WAF1/Cip1) functions as a suppressor of malignant skin tumor formation and a determinant of keratinocyte stem-cell potential

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7 January 2021

Hematopoietic stem cell quiescence maintained by p21cip1/waf1

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7 January 2021

Tumor suppression by p27Kip1 and p21Cip1 during chemically induced skin carcinogenesis

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https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900019-6

7 January 2021

The cell cycle inhibitor p21 controls T-cell proliferation and sex-linked lupus development.

1 reference

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7 January 2021

10.1016/S0304-419X(00)00019-6

Identifiers

DOI

1 reference

30 July 2017

1 reference