Necroptosis drives motor neuron death in models of both sporadic and familial ALS. (Q34039826)

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7 March 2020

title

Necroptosis drives motor neuron death in models of both sporadic and familial ALS (English)

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7 March 2020

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amyotrophic lateral sclerosis

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1

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Mackenzie Mathis

4

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7 March 2020

Burcin Ikiz

7

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Hiroshi Mitsumoto

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7 March 2020

Christopher E. Henderson

16

object named as

Christopher E Henderson

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7 March 2020

author name string

Virginia Le Verche

2

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Changhao Yu

3

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Kristin A Politi

5

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Sudarshan Phani

6

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Lucas Hoffmann

8

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Martijn Koolen

9

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Tetsuya Nagata

10

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Dimitra Papadimitriou

11

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Peter Nagy

12

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Shingo Kariya

14

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Hynek Wichterle

15

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7 March 2020

Serge Przedborski

17

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language of work or name

English

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publication date

6 February 2014

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7 March 2020

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7 March 2020

volume

81

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issue

5

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7 March 2020

page(s)

1001-1008

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Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death

7 March 2020

cites work

1 reference

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TNF dually mediates resistance and susceptibility to mycobacteria via mitochondrial reactive oxygen species

5 July 2018

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Accelerated high-yield generation of limb-innervating motor neurons from human stem cells

5 July 2018

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An over-oxidized form of superoxide dismutase found in sporadic amyotrophic lateral sclerosis with bulbar onset shares a toxic mechanism with mutant SOD1

5 July 2018

1 reference

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The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways

5 July 2018

1 reference

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Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase

5 July 2018

1 reference

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Astrocytes carrying the superoxide dismutase 1 (SOD1G93A) mutation induce wild-type motor neuron degeneration in vivo

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951532

Astrocytes from familial and sporadic ALS patients are toxic to motor neurons

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951532

Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS

5 July 2018

1 reference

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Motor neuron diversity in development and disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951532

AIF promotes chromatinolysis and caspase-independent programmed necrosis by interacting with histone H2AX

5 July 2018

1 reference

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Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951532

RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951532

Non-cell-autonomous effect of human SOD1 G37R astrocytes on motor neurons derived from human embryonic stem cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951532

Human embryonic stem cell-derived motor neurons are sensitive to the toxic effect of glial cells carrying an ALS-causing mutation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951532

Bax- or Bak-induced mitochondrial fission can be uncoupled from cytochrome C release

5 July 2018

1 reference

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Identification of RIP1 kinase as a specific cellular target of necrostatins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951532

Selective association of misfolded ALS-linked mutant SOD1 with the cytoplasmic face of mitochondria.

5 July 2018

1 reference

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Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons

5 July 2018

1 reference

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Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model

5 July 2018

1 reference

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Clearance of apoptotic and necrotic cells and its immunological consequences

5 July 2018

1 reference

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Directed differentiation of embryonic stem cells into motor neurons

5 July 2018

1 reference

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Astrocyte activation by fibroblast growth factor-1 and motor neuron apoptosis: implications for amyotrophic lateral sclerosis

5 July 2018

1 reference

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Establishment of human adult astrocyte cultures derived from postmortem multiple sclerosis and control brain and spinal cord regions: immunophenotypical and functional characterization

29 October 2018

1 reference

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10.1016/J.NEURON.2014.01.011

29 October 2018

Identifiers

DOI

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7 March 2020

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7 March 2020

PubMed publication ID

24508385

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