Translocation of proteins through the Sec61 and SecYEG channels (Q34046866)

30 July 2017

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title

Translocation of proteins through the Sec61 and SecYEG channels (English)

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30 July 2017

Elisabet C Mandon

1

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30 July 2017

Steven F Trueman

series ordinal

2

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30 July 2017

Reid Gilmore

series ordinal

3

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30 July 2017

publication date

18 May 2009

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Current Opinion in Cell Biology

30 July 2017

published in

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30 July 2017

volume

21

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30 July 2017

issue

4

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30 July 2017

page(s)

501-507

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Synthetic peptides identify a second periplasmic site for the plug of the SecYEG protein translocation complex

30 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916700

Inter-species complementation of the translocon beta subunit requires only its transmembrane domain

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916700

Conformational transition of Sec machinery inferred from bacterial SecYE structures

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916700

Structure of a complex of the ATPase SecA and the protein-translocation channel

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916700

Molecular code for protein insertion in the endoplasmic reticulum membrane is similar for N(in)-C(out) and N(out)-C(in) transmembrane helices

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916700

SecA, the motor of the secretion machine, binds diverse partners on one interactive surface

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916700

Analysis of polypeptide movement in the SecY channel during SecA-mediated protein translocation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916700

An interaction between the SRP receptor and the translocon is critical during cotranslational protein translocation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916700

Ribosome binding of a single copy of the SecY complex: implications for protein translocation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916700

Structural Basis for Signal-Sequence Recognition by the Translocase Motor SecA as Determined by NMR

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916700

Nanodiscs unravel the interaction between the SecYEG channel and its cytosolic partner SecA.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916700

Different modes of SecY-SecA interactions revealed by site-directed in vivo photo-cross-linking

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916700

Oligomeric states of the SecA and SecYEG core components of the bacterial Sec translocon

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916700

The plug domain of yeast Sec61p is important for efficient protein translocation, but is not essential for cell viability

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916700

Investigating the SecY plug movement at the SecYEG translocation channel.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916700

Disulfide bridge formation between SecY and a translocating polypeptide localizes the translocation pore to the center of SecY.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916700

Recognition of transmembrane helices by the endoplasmic reticulum translocon.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916700

Identification of cytoplasmic residues of Sec61p involved in ribosome binding and cotranslational translocation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916700

A large conformational change of the translocation ATPase SecA

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916700

X-ray structure of a protein-conducting channel

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916700

Cooperation of transmembrane segments during the integration of a double-spanning protein into the ER membrane

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916700

The SecYEG preprotein translocation channel is a conformationally dynamic and dimeric structure

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916700

An essential amino acid residue in the protein translocation channel revealed by targeted random mutagenesis of SecY

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916700

Role of the cytoplasmic segments of Sec61alpha in the ribosome-binding and translocation-promoting activities of the Sec61 complex

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916700

Signal sequence recognition in posttranslational protein transport across the yeast ER membrane.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916700

Alignment of conduits for the nascent polypeptide chain in the ribosome-Sec61 complex

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916700

A second trimeric complex containing homologs of the Sec61p complex functions in protein transport across the ER membrane of S. cerevisiae

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916700

Secretory proteins move through the endoplasmic reticulum membrane via an aqueous, gated pore.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916700

Disruption of the gene encoding p12 (SecG) reveals the direct involvement and important function of SecG in the protein translocation of Escherichia coli at low temperature.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916700

SSS1 encodes a stabilizing component of the Sec61 subcomplex of the yeast protein translocation apparatus.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916700

Posttranslational protein transport in yeast reconstituted with a purified complex of Sec proteins and Kar2p

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916700

The ATPase activity of SecA is regulated by acidic phospholipids, SecY, and the leader and mature domains of precursor proteins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916700

A role for the two-helix finger of the SecA ATPase in protein translocation.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916700

A large conformational change couples the ATP binding site of SecA to the SecY protein channel.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916700

Structural determinants of lateral gate opening in the protein translocon

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916700

The transmembrane domain is sufficient for Sbh1p function, its association with the Sec61 complex, and interaction with Rtn1p.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916700

The active protein-conducting channel of Escherichia coli contains an apolar patch.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916700

The plug domain of the SecY protein stabilizes the closed state of the translocation channel and maintains a membrane seal

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916700

Arginine 357 of SecY is needed for SecA-dependent initiation of preprotein translocation.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916700

Protein translocation is mediated by oligomers of the SecY complex with one SecY copy forming the channel.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916700

Deregulation of the SecYEG translocation channel upon removal of the plug domain.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916700

Sequential triage of transmembrane segments by Sec61alpha during biogenesis of a native multispanning membrane protein

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916700

Nascent membrane and secretory proteins differ in FRET-detected folding far inside the ribosome and in their exposure to ribosomal proteins.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916700

Architecture of the protein-conducting channel associated with the translating 80S ribosome

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916700

Binding of secretory precursor polypeptides to a translocon subcomplex is regulated by BiP.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916700

SecA promotes preprotein translocation by undergoing ATP-driven cycles of membrane insertion and deinsertion.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916700

Atomic Model of the E.coli Membrane-bound Protein Translocation Complex SecYEG

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916700

Mutations in the Sec61p Channel Affecting Signal Sequence Recognition and Membrane Protein Topology

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916700

The Structure of Ribosome-Channel Complexes Engaged in Protein Translocation

10 December 2018

1 reference

12 December 2020

SecE-dependent overproduction of SecY in Escherichia coli. Evidence for interaction between two components of the secretory machinery

1 reference

12 December 2020

Determining the conductance of the SecY protein translocation channel for small molecules

1 reference

12 December 2020

Oligomeric Rings of the Sec61p Complex Induced by Ligands Required for Protein Translocation

1 reference

12 December 2020

Molecular mechanism of membrane protein integration into the endoplasmic reticulum

1 reference

12 December 2020

The aqueous pore through the translocon has a diameter of 40-60 A during cotranslational protein translocation at the ER membrane

1 reference

12 December 2020

SecA is required for the insertion of inner membrane proteins targeted by the Escherichia coli signal recognition particle

1 reference

12 December 2020

Identification of Two Interaction Sites in SecY that Are Important for the Functional Interaction with SecA

1 reference

12 December 2020

Slow translocon gating causes cytosolic exposure of transmembrane and lumenal domains during membrane protein integration

1 reference

12 December 2020

The Sec61p complex mediates the integration of a membrane protein by allowing lipid partitioning of the transmembrane domain

1 reference

12 December 2020

10.1016/J.CEB.2009.04.010

Identifiers

DOI

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30 July 2017

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30 July 2017

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