Architecture of the protein-conducting channel associated with the translating 80S ribosome (Q49485686)

20 February 2018

title

Architecture of the protein-conducting channel associated with the translating 80S ribosome (English)

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20 February 2018

8

Blobel G

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20 February 2018

Beckmann R

1

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20 February 2018

Spahn CM

2

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20 February 2018

Eswar N

3

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20 February 2018

Helmers J

4

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20 February 2018

Penczek PA

5

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20 February 2018

Sali A

6

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20 February 2018

Frank J

7

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20 February 2018

language of work or name

English

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publication date

1 November 2001

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20 February 2018

published in

Cell

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20 February 2018

volume

107

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20 February 2018

issue

3

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20 February 2018

page(s)

361-372

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20 February 2018

Direct Visualization of A-, P-, and E-Site Transfer RNAs in the Escherichia coli Ribosome

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Nascent polypeptide chains exit the ribosome in the same relative position in both eucaryotes and procaryotes

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Solution structure of the E. coli 70S ribosome at 11.5 A resolution

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Three-dimensional cryo-electron microscopy localization of EF2 in the Saccharomyces cerevisiae 80S ribosome at 17.5 A resolution

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The aqueous pore through the translocon has a diameter of 40-60 A during cotranslational protein translocation at the ER membrane

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BiP maintains the permeability barrier of the ER membrane by sealing the lumenal end of the translocon pore before and early in translocation

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Oligomeric Rings of the Sec61p Complex Induced by Ligands Required for Protein Translocation

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Sequence-specific alteration of the ribosome-membrane junction exposes nascent secretory proteins to the cytosol

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The Sec61p complex mediates the integration of a membrane protein by allowing lipid partitioning of the transmembrane domain

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The translocon: a dynamic gateway at the ER membrane

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A posttargeting signal sequence recognition event in the endoplasmic reticulum membrane

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7 January 2021

Binding of ribosomes to the rough endoplasmic reticulum mediated by the Sec61p-complex

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7 January 2021

The signal recognition particle

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7 January 2021

Both lumenal and cytosolic gating of the aqueous ER translocon pore are regulated from inside the ribosome during membrane protein integration

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SecYEG assembles into a tetramer to form the active protein translocation channel

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The protein-conducting channel in the membrane of the endoplasmic reticulum is open laterally toward the lipid bilayer.

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Protein transport by purified yeast Sec complex and Kar2p without membranes

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Protein translocation: tunnel vision

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The Structure of Ribosome-Channel Complexes Engaged in Protein Translocation

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The bacterial SecY/E translocation complex forms channel-like structures similar to those of the eukaryotic Sec61p complex

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7 January 2021

A comparison of the yeast and rabbit 80 S ribosome reveals the topology of the nascent chain exit tunnel, inter-subunit bridges and mammalian rRNA expansion segments

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7 January 2021

Molecular mechanism of membrane protein integration into the endoplasmic reticulum

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7 January 2021

Signal sequence recognition in cotranslational translocation by protein components of the endoplasmic reticulum membrane

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7 January 2021

Signal sequences specify the targeting route to the endoplasmic reticulum membrane

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The structural basis of ribosome activity in peptide bond synthesis

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Signal sequence recognition in posttranslational protein transport across the yeast ER membrane.

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Evolutionarily conserved binding of ribosomes to the translocation channel via the large ribosomal RNA.

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Evidence for the loop model of signal-sequence insertion into the endoplasmic reticulum

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7 January 2021

A protein-conducting channel in the endoplasmic reticulum

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7 January 2021

A method for differentiating proteins from nucleic acids in intermediate-resolution density maps: cryo-electron microscopy defines the quaternary structure of the Escherichia coli 70S ribosome

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7 January 2021

Structure of the 80S ribosome from Saccharomyces cerevisiae--tRNA-ribosome and subunit-subunit interactions

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7 January 2021

Arrangement of tRNAs in pre- and posttranslocational ribosomes revealed by electron cryomicroscopy.

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7 January 2021

An rRNA variable region has an evolutionarily conserved essential role despite sequence divergence

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7 January 2021

Structure of the junction between communicating cells

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7 January 2021

Electron microscopy and computer image averaging of ice-embedded large ribosomal subunits from Escherichia coli

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7 January 2021

Oligomeric complexes involved in translocation of proteins across the membrane of the endoplasmic reticulum

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7 January 2021

Secretory protein translocation in a yeast cell-free system can occur posttranslationally and requires ATP hydrolysis

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7 January 2021

Determination of the transmembrane topology of yeast Sec61p, an essential component of the endoplasmic reticulum translocation complex

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7 January 2021

10.1016/S0092-8674(01)00541-4

Identifiers

DOI

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20 February 2018

release_lffbwzxkfvfaflbofkcsogpsza

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24 November 2022

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20 February 2018