Joint binding of OTX2 and MYC in promotor regions is associated with high gene expression in medulloblastoma (Q34053468)

30 July 2017

title

Joint binding of OTX2 and MYC in promotor regions is associated with high gene expression in medulloblastoma (English)

1 reference

30 July 2017

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Jens Bunt

1

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Rogier Versteeg

object named as

Rogier Versteeg

5

0 references

Jan Koster

object named as

Jan Koster

4

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Marcel Kool

6

object named as

Marcel Kool

1 reference

30 July 2017

Nancy E Hasselt

2

1 reference

30 July 2017

Danny A Zwijnenburg

3

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30 July 2017

language of work or name

English

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publication date

10 October 2011

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30 July 2017

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30 July 2017

volume

6

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30 July 2017

issue

10

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30 July 2017

page(s)

e26058

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Creative Commons Attribution 4.0 International

30 July 2017

copyright license

start time

10 October 2011

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

OTX2 directly activates cell cycle genes and inhibits differentiation in medulloblastoma cells

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Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome

5 July 2018

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Regulation of cell cycle genes and induction of senescence by overexpression of OTX2 in medulloblastoma cell lines

5 July 2018

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A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs

5 July 2018

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SOX9, through interaction with microphthalmia-associated transcription factor (MITF) and OTX2, regulates BEST1 expression in the retinal pigment epithelium

5 July 2018

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OTX2 is critical for the maintenance and progression of Shh-independent medulloblastomas

5 July 2018

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5 July 2018

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Otx2 induction of the gonadotropin-releasing hormone promoter is modulated by direct interactions with Grg co-repressors

5 July 2018

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Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma

5 July 2018

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Outcome prediction in pediatric medulloblastoma based on DNA copy-number aberrations of chromosomes 6q and 17q and the MYC and MYCN loci

5 July 2018

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Stat3 and c-Myc genome-wide promoter occupancy in embryonic stem cells

5 July 2018

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Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features

5 July 2018

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Global analysis of in vivo Foxa2-binding sites in mouse adult liver using massively parallel sequencing

5 July 2018

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Integration of external signaling pathways with the core transcriptional network in embryonic stem cells

5 July 2018

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5 July 2018

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Molecular links among the causative genes for ocular malformation: Otx2 and Sox2 coregulate Rax expression

5 July 2018

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Genome-wide pattern of TCF7L2/TCF4 chromatin occupancy in colorectal cancer cells

5 July 2018

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Crx activates opsin transcription by recruiting HAT-containing co-activators and promoting histone acetylation

5 July 2018

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Genome-wide profiles of STAT1 DNA association using chromatin immunoprecipitation and massively parallel sequencing

5 July 2018

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5 July 2018

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In vivo identification of a 107-base pair promoter element mediating neuron-specific expression of mouse gonadotropin-releasing hormone

5 July 2018

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Gbx2 and Otx2 interact with the WD40 domain of Groucho/Tle corepressors

5 July 2018

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A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration

5 July 2018

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Molecular dissection reveals decreased activity and not dominant negative effect in human OTX2 mutants

5 July 2018

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DNA motifs in human and mouse proximal promoters predict tissue-specific expression

5 July 2018

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OTX1 and OTX2 expression correlates with the clinicopathologic classification of medulloblastomas

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189962

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

5 July 2018

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Polyglutamine-expanded ataxin-7 inhibits STAGA histone acetyltransferase activity to produce retinal degeneration

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189962

Identification of OTX2 as a medulloblastoma oncogene whose product can be targeted by all-trans retinoic acid

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189962

Genomic amplification of orthodenticle homologue 2 in medulloblastomas

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189962

Comparison of medulloblastoma and normal neural transcriptomes identifies a restricted set of activated genes

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189962

PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

5 July 2018

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DAVID: Database for Annotation, Visualization, and Integrated Discovery

5 July 2018

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5 July 2018

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OTX2 regulates expression of DOPAchrome tautomerase in human retinal pigment epithelium

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189962

"Stemness": transcriptional profiling of embryonic and adult stem cells

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189962

MYCC and MYCN oncogene amplification in medulloblastoma. A fluorescence in situ hybridization study on paraffin sections from the Children's Oncology Group

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189962

The chromatin structure of the dual c-myc promoter P1/P2 is regulated by separate elements

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189962

Genome-wide location and function of DNA binding proteins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189962

The Otx2 homeoprotein regulates expression from the gonadotropin-releasing hormone proximal promoter

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189962

OTX2 directly interacts with LIM1 and HNF-3beta

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189962

Binding properties of the human homeodomain protein OTX2 to a DNA target sequence

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189962

Meis2 competes with the Groucho co-repressor Tle4 for binding to Otx2 and specifies tectal fate without induction of a secondary midbrain-hindbrain boundary organizer.

5 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0026058

A conserved 30 base pair element in the Wnt-5a promoter is sufficient both to drive its' early embryonic expression and to mediate its' repression by otx2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0026058

Low-level copy number changes of MYC genes have a prognostic impact in medulloblastoma.

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0026058

Beta-catenin status in paediatric medulloblastomas: correlation of immunohistochemical expression with mutational status, genetic profiles, and clinical characteristics

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0026058

Genes differentially expressed in medulloblastoma and fetal brain.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3189962

10.1371/JOURNAL.PONE.0026058

28 October 2018

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DOI

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30 July 2017

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30 July 2017

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