Apoptosis in the nervous system (Q34068965)

30 July 2017

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title

Apoptosis in the nervous system (English)

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30 July 2017

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Yuan J

1

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30 July 2017

Yankner BA

series ordinal

2

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30 July 2017

language of work or name

English

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publication date

1 October 2000

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30 July 2017

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30 July 2017

volume

407

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30 July 2017

issue

6805

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30 July 2017

page(s)

802-809

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Proliferation, differentiation and degeneration in the spinal ganglia of the chick embryo under normal and experimental conditions

30 July 2017

cites work

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7 January 2021

Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation

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7 January 2021

Genetics of programmed cell death in C. elegans: past, present and future.

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7 January 2021

Prevention of vertebrate neuronal death by the crmA gene

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7 January 2021

Bcl-2 gene family in the nervous system

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7 January 2021

Prevention of programmed cell death of sympathetic neurons by the bcl-2 proto-oncogene

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7 January 2021

Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia

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7 January 2021

Neonatal motoneurons overexpressing the bcl-2 protooncogene in transgenic mice are protected from axotomy-induced cell death.

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7 January 2021

Bcl-2 overexpression prevents motoneuron cell body loss but not axonal degeneration in a mouse model of a neurodegenerative disease

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7 January 2021

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

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7 January 2021

Inactivation of bcl-2 results in progressive degeneration of motoneurons, sympathetic and sensory neurons during early postnatal development

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7 January 2021

bcl-x is expressed in embryonic and postnatal neural tissues and functions to prevent neuronal cell death

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7 January 2021

Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice

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7 January 2021

BAX is required for neuronal death after trophic factor deprivation and during development

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7 January 2021

Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3

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7 January 2021

Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development

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7 January 2021

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7 January 2021

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

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7 January 2021

Dual role of caspase-11 in mediating activation of caspase-1 and caspase-3 under pathological conditions

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7 January 2021

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta

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7 January 2021

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

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7 January 2021

Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9

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7 January 2021

Structural and functional properties of the TRK family of neurotrophin receptors

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7 January 2021

Phosphoinositide kinases

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7 January 2021

Activated phosphatidylinositol 3-kinase and Akt kinase promote survival of superior cervical neurons

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7 January 2021

Cellular survival: a play in three Akts

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7 January 2021

Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death

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7 January 2021

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

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7 January 2021

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

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7 January 2021

CREB is a regulatory target for the protein kinase Akt/PKB

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7 January 2021

Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons

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7 January 2021

Induction of NF-kappaB by the Akt/PKB kinase

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7 January 2021

Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms

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7 January 2021

Role of Ca2+ channels in the ability of membrane depolarization to prevent neuronal death induced by trophic-factor deprivation: evidence that levels of internal Ca2+ determine nerve growth factor dependence of sympathetic ganglion cells

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7 January 2021

Neuronal activity-dependent cell survival mediated by transcription factor MEF2

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7 January 2021

Depolarization and neurotrophins converge on the phosphatidylinositol 3-kinase-Akt pathway to synergistically regulate neuronal survival

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7 January 2021

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

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7 January 2021

Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis

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7 January 2021

A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death

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7 January 2021

The cell death-promoting gene DP5, which interacts with the BCL2 family, is induced during neuronal apoptosis following exposure to amyloid beta protein

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7 January 2021

BAX translocation is a critical event in neuronal apoptosis: regulation by neuroprotectants, BCL-2, and caspases

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7 January 2021

Evidence of a novel event during neuronal death: development of competence-to-die in response to cytoplasmic cytochrome c

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7 January 2021

Signalling through the neurotrophin receptor p75NTR.

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7 January 2021

Induction of cell death by endogenous nerve growth factor through its p75 receptor

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7 January 2021

Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75.

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7 January 2021

The p75 neurotrophin receptor mediates neuronal apoptosis and is essential for naturally occurring sympathetic neuron death

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7 January 2021

TrkB signalling inhibits p75-mediated apoptosis induced by nerve growth factor in embryonic proprioceptive neurons

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7 January 2021

Induction of DNA fragmentation after 10 to 120 minutes of focal cerebral ischemia in rats

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7 January 2021

Apoptosis and necrosis after reversible focal ischemia: an in situ DNA fragmentation analysis.

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7 January 2021

Activation and cleavage of caspase-3 in apoptosis induced by experimental cerebral ischemia.

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7 January 2021

Neurodegeneration in excitotoxicity, global cerebral ischemia, and target deprivation: A perspective on the contributions of apoptosis and necrosis

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7 January 2021

Immunohistochemical evidence for apoptosis in Alzheimerʼs disease

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7 January 2021

In situ labeling of dying cortical neurons in normal aging and in Alzheimer's disease: correlations with senile plaques and disease progression

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7 January 2021

Alzheimer's disease: genotypes, phenotypes, and treatments

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7 January 2021

Mechanisms of neuronal degeneration in Alzheimer's disease

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7 January 2021

Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity

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7 January 2021

Hydrogen peroxide mediates amyloid beta protein toxicity

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7 January 2021

Calcium-destabilizing and neurodegenerative effects of aggregated beta-amyloid peptide are attenuated by basic FGF.

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7 January 2021

Apoptosis is induced by beta-amyloid in cultured central nervous system neurons

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7 January 2021

RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease

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7 January 2021

Binding of beta-amyloid to the p75 neurotrophin receptor induces apoptosis. A possible mechanism for Alzheimer's disease.

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7 January 2021

Amyloid beta interacts with the amyloid precursor protein: a potential toxic mechanism in Alzheimer's disease.

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7 January 2021

Aggregated amyloid-beta protein induces cortical neuronal apoptosis and concomitant "apoptotic" pattern of gene induction.

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7 January 2021

Caspase-2 mediates neuronal cell death induced by beta-amyloid

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7 January 2021

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

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7 January 2021

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

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7 January 2021

Alzheimer's disease: genetic studies and transgenic models

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7 January 2021

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

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7 January 2021

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

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7 January 2021

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

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7 January 2021

Presenilins, the endoplasmic reticulum, and neuronal apoptosis in Alzheimer's disease.

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7 January 2021

Specific domains of beta-amyloid from Alzheimer plaque elicit neuron killing in human microglia

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7 January 2021

Microglial activation resulting from CD40-CD40L interaction after beta-amyloid stimulation.

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7 January 2021

Role of microglia and host prion protein in neurotoxicity of a prion protein fragment

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7 January 2021

Microglia as mediators of inflammatory and degenerative diseases

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7 January 2021

Apoptosis induced by infection of primary brain cultures with diverse human immunodeficiency virus type 1 isolates: evidence for a role of the envelope.

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7 January 2021

Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo

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7 January 2021

Polyglutamines, nuclear inclusions and neurodegeneration

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7 January 2021

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

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7 January 2021

Reversing neurodegeneration: a promise unfolds

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7 January 2021

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

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7 January 2021

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

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7 January 2021

Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice

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7 January 2021

Caspase-8 is required for cell death induced by expanded polyglutamine repeats.

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7 January 2021

Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease

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7 January 2021

Neuropathological classification of Huntington's disease

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7 January 2021

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

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7 January 2021

Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease

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7 January 2021

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

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7 January 2021

From Charcot to SOD1: mechanisms of selective motor neuron death in ALS.

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7 January 2021

Mutations associated with amyotrophic lateral sclerosis convert superoxide dismutase from an antiapoptotic gene to a proapoptotic gene: studies in yeast and neural cells

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7 January 2021

Caspase-1 is activated in neural cells and tissue with amyotrophic lateral sclerosis-associated mutations in copper-zinc superoxide dismutase.

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7 January 2021

Bcl-2: Prolonging Life in a Transgenic Mouse Model of Familial Amyotrophic Lateral Sclerosis

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7 January 2021

Functional Role of Caspase-1 and Caspase-3 in an ALS Transgenic Mouse Model

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7 January 2021

Inhibition of ICE slows ALS in mice

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7 January 2021

Mice deficient in interleukin-1 converting enzyme are resistant to neonatal hypoxic-ischemic brain damage

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7 January 2021

Differential requirement for caspase 9 in apoptotic pathways in vivo.

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7 January 2021

Neurodegenerative tauopathies: human disease and transgenic mouse models

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7 January 2021

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

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7 January 2021

Identifiers

DOI

10.1038/35037739

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30 July 2017

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