Control of central and peripheral tolerance by Aire (Q34177944)

31 July 2017

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title

Control of central and peripheral tolerance by Aire (English)

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31 July 2017

Todd C Metzger

1

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31 July 2017

Mark S Anderson

series ordinal

2

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31 July 2017

publication date

1 May 2011

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31 July 2017

published in

Immunological Reviews

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31 July 2017

volume

241

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31 July 2017

issue

1

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31 July 2017

page(s)

89-103

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Clues to immune tolerance: the monogenic autoimmune syndromes

31 July 2017

cites work

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28 July 2018

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Diversity of TCRs on natural Foxp3+ T cells in mice lacking Aire expression

28 July 2018

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Autonomous role of medullary thymic epithelial cells in central CD4(+) T cell tolerance

28 July 2018

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28 July 2018

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Biphasic Aire expression in early embryos and in medullary thymic epithelial cells before end-stage terminal differentiation

28 July 2018

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Identification of an autoantigen demonstrates a link between interstitial lung disease and a defect in central tolerance.

28 July 2018

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Lymph node-resident lymphatic endothelial cells mediate peripheral tolerance via Aire-independent direct antigen presentation

28 July 2018

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Lymph node fibroblastic reticular cells directly present peripheral tissue antigen under steady-state and inflammatory conditions

28 July 2018

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An autoimmune response to odorant binding protein 1a is associated with dry eye in the Aire-deficient mouse

28 July 2018

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Human peripheral lymphoid tissues contain autoimmune regulator-expressing dendritic cells

28 July 2018

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Aire's partners in the molecular control of immunological tolerance

28 July 2018

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Regulatory T cells exert checks and balances on self tolerance and autoimmunity

28 July 2018

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A hypomorphic allele of ZAP-70 reveals a distinct thymic threshold for autoimmune disease versus autoimmune reactivity

28 July 2018

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Deaf1 isoforms control the expression of genes encoding peripheral tissue antigens in the pancreatic lymph nodes during type 1 diabetes

28 July 2018

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The thymic medulla: a unique microenvironment for intercellular self-antigen transfer

28 July 2018

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Neonatal tolerance revisited: a perinatal window for Aire control of autoimmunity

28 July 2018

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28 July 2018

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Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance

28 July 2018

1 reference

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PHD finger of autoimmune regulator: an epigenetic link between the histone modifications and tissue-specific antigen expression in thymus

28 July 2018

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Promiscuous gene expression patterns in single medullary thymic epithelial cells argue for a stochastic mechanism

28 July 2018

1 reference

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Opposing functions of the T cell receptor kinase ZAP-70 in immunity and tolerance differentially titrate in response to nucleotide substitutions.

28 July 2018

1 reference

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DNA-PK contributes to the phosphorylation of AIRE: importance in transcriptional activity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093413

AIRE recruits P-TEFb for transcriptional elongation of target genes in medullary thymic epithelial cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093413

Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093413

TCR-based lineage tracing: no evidence for conversion of conventional into regulatory T cells in response to a natural self-antigen in pancreatic islets

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093413

Deletional self-tolerance to a melanocyte/melanoma antigen derived from tyrosinase is mediated by a radio-resistant cell in peripheral and mesenteric lymph nodes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093413

Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093413

Zoned out: functional mapping of stromal signaling microenvironments in the thymus

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093413

Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice

28 July 2018

1 reference

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Spontaneous autoimmunity prevented by thymic expression of a single self-antigen

28 July 2018

1 reference

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Alteration of intra-pancreatic target-organ specificity by abrogation of Aire in NOD mice

28 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093413

Autoimmune polyendocrinopathy syndrome type 1 (APS1) and AIRE gene: new views on molecular basis of autoimmunity

28 July 2018

1 reference

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Modifier loci condition autoimmunity provoked by Aire deficiency

28 July 2018

1 reference

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Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093413

Cooperative activation of transcription by autoimmune regulator AIRE and CBP.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093413

Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation

28 July 2018

1 reference

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Gene dosage--limiting role of Aire in thymic expression, clonal deletion, and organ-specific autoimmunity.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093413

Toll-like receptor control of the adaptive immune responses

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093413

Thymic medullary epithelial cell differentiation, thymocyte emigration, and the control of autoimmunity require lympho-epithelial cross talk via LTbetaR.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093413

Aire regulates negative selection of organ-specific T cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093413

Positive and negative selection of T cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093413

Projection of an immunological self shadow within the thymus by the aire protein

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093413

Lineage plasticity and commitment in T-cell development

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093413

Aire deficient mice develop multiple features of APECED phenotype and show altered immune response

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093413

CREB-binding protein and p300 in transcriptional regulation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093413

Normal thymic architecture and negative selection are associated with Aire expression, the gene defective in the autoimmune-polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093413

Mutations in the AIRE gene: effects on subcellular location and transactivation function of the autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy protein

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093413

Thymus and autoimmunity: production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093413

Thymocyte development in the absence of pre-T cell receptor extracellular immunoglobulin domains

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093413

An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093413

Positional cloning of the APECED gene

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093413

Essential role for ZAP-70 in both positive and negative selection of thymocytes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093413

Notch activity influences the alphabeta versus gammadelta T cell lineage decision

28 July 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2011.01008.X

Inactivation of Notch1 impairs VDJbeta rearrangement and allows pre-TCR-independent survival of early alpha beta Lineage Thymocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2011.01008.X

Peripheral-antigen-expressing cells in thymic medulla: factors in self-tolerance and autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2011.01008.X

Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2011.01008.X

Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2011.01008.X

Autoimmune regulator is expressed in the cells regulating immune tolerance in thymus medulla.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1600-065X.2011.01008.X

The NOD mouse: a model of immune dysregulation

21 January 2018

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Effector mechanisms of the autoimmune syndrome in the murine model of autoimmune polyglandular syndrome type 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2011.01008.X

The autoimmune regulator PHD finger binds to non-methylated histone H3K4 to activate gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2011.01008.X

The autoimmune regulator (AIRE) is a DNA-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2011.01008.X

Chromosomal clustering of genes controlled by the aire transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2011.01008.X

AIRE's CARD revealed, a new structure for central tolerance provokes transcriptional plasticity

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1600-065X.2011.01008.X

Global relevance of Aire binding to hypomethylated lysine-4 of histone-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2011.01008.X

Ablation and regeneration of tolerance-inducing medullary thymic epithelial cells after cyclosporine, cyclophosphamide, and dexamethasone treatment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2011.01008.X

Aire-dependent alterations in medullary thymic epithelium indicate a role for Aire in thymic epithelial differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2011.01008.X

Linking signalling pathways, thymic stroma integrity and autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2011.01008.X

The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2011.01008.X

The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2011.01008.X

Deletional tolerance mediated by extrathymic Aire-expressing cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2011.01008.X

The cellular mechanism of Aire control of T cell tolerance.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1600-065X.2011.01008.X

Mechanisms of an autoimmunity syndrome in mice caused by a dominant mutation in Aire

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2011.01008.X

Regulatory T cell defect in APECED patients is associated with loss of naive FOXP3(+) precursors and impaired activated population.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2011.01008.X

A specific anti-Aire antibody reveals aire expression is restricted to medullary thymic epithelial cells and not expressed in periphery

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2011.01008.X

Peripheral antigen display by lymph node stroma promotes T cell tolerance to intestinal self

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2011.01008.X

Self-reactive T cells selected on thymic cortical epithelium are polyclonal and are pathogenic in vivo.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093413

The autoimmune regulator PHD finger binds to non-methylated histone H3K4 to activate gene expression

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093413

Crucial role of the pre-T-cell receptor α gene in development of ap but not γδ T cells

28 October 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2011.01008.X

Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2011.01008.X

Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2011.01008.X

RNA and protein expression of the murine autoimmune regulator gene (Aire) in normal, RelB-deficient and in NOD mouse

21 January 2018

1 reference

12 December 2020

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

1 reference

12 December 2020

Expression of AIRE gene in peripheral monocyte/dendritic cell lineage

1 reference

12 December 2020

T cell receptor excision circle assessment of thymopoiesis in aging mice

1 reference

12 December 2020

Generation of a complete thymic microenvironment by MTS24(+) thymic epithelial cells

1 reference

12 December 2020

Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors

1 reference

12 December 2020

Mapping DNA-binding domains of the autoimmune regulator protein

1 reference

12 December 2020

Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus of Aire-deficient mice

1 reference

12 December 2020

A defect of regulatory T cells in patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy

1 reference

12 December 2020

The autoimmune regulator directly controls the expression of genes critical for thymic epithelial function

1 reference

12 December 2020

Lymphotoxin pathway and Aire influences on thymic medullary epithelial cells are unconnected

1 reference

12 December 2020

Autoantigen-Specific Interactions with CD4+ Thymocytes Control Mature Medullary Thymic Epithelial Cell Cellularity

1 reference

12 December 2020

10.1111/J.1600-065X.2011.01008.X

Identifiers

DOI

1 reference

31 July 2017

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31 July 2017

1 reference