Vascular and metabolic dysfunction in Alzheimer's disease: a review (Q34193337)

31 July 2017

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title

Vascular and metabolic dysfunction in Alzheimer's disease: a review (English)

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31 July 2017

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Ian V J Murray

1

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31 July 2017

Joseph F Proza

series ordinal

2

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31 July 2017

Farida Sohrabji

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3

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31 July 2017

John M Lawler

series ordinal

4

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31 July 2017

language of work or name

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16 June 2011

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Experimental Biology and Medicine

31 July 2017

published in

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31 July 2017

volume

236

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31 July 2017

issue

7

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31 July 2017

page(s)

772-782

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Cerebral perfusion as a diagnostic marker of early Alzheimer's disease

31 July 2017

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Is Alzheimer's disease a neurodegenerative or a vascular disorder? Data, dogma, and dialectics

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Use of angiotensin receptor blockers and risk of dementia in a predominantly male population: prospective cohort analysis

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Modulation of amyloid beta-protein clearance and Alzheimer's disease susceptibility by the LDL receptor-related protein pathway.

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Amyloid-peptide vaccinations reduce {beta}-amyloid plaques but exacerbate vascular deposition and inflammation in the retina of Alzheimer's transgenic mice

21 January 2018

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Consequence of Abeta immunization on the vasculature of human Alzheimer's disease brain.

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Complete rescue of cerebrovascular function in aged Alzheimer's disease transgenic mice by antioxidants and pioglitazone, a peroxisome proliferator-activated receptor gamma agonist

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Alzheimer disease and cerebrovascular pathology: an update

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Triflusal reduces cerebral ischemia induced inflammation in a combined mouse model of Alzheimer's disease and stroke

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Alzheimer's disease: the cholesterol connection

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Link between heart disease, cholesterol, and Alzheimer's disease: a review

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Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model

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Cholesterol, statins and dementia.

21 January 2018

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Inhibition of reactive oxygen species by Lovastatin downregulates vascular endothelial growth factor expression and ameliorates blood-retinal barrier breakdown in db/db mice: role of NADPH oxidase 4.

21 January 2018

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NADPH oxidase isoforms and anti-hypertensive effects of atorvastatin demonstrated in two animal models

21 January 2018

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Promising strategies for the prevention of dementia

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Angiotensins in Alzheimer's disease - friend or foe?

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Valsartan lowers brain beta-amyloid protein levels and improves spatial learning in a mouse model of Alzheimer disease

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Amino-terminal Deletions Enhance Aggregation of β-Amyloid Peptides in Vitro

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Common angiotensin receptor blockers may directly modulate the immune system via VDR, PPAR and CCR2b

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Oxidative stress in Alzheimer's disease brain: new insights from redox proteomics

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Decline in mitochondrial bioenergetics and shift to ketogenic profile in brain during reproductive senescence

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Alzheimer's disease is type 3 diabetes-evidence reviewed

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Ketone bodies as a therapeutic for Alzheimer's disease

21 January 2018

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A metabolic basis for Alzheimer disease

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Modeling sporadic Alzheimer's disease: the insulin resistant brain state generates multiple long-term morphobiological abnormalities including hyperphosphorylated tau protein and amyloid-beta

21 January 2018

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Abeta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine

21 January 2018

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Increased risk of type 2 diabetes in Alzheimer disease

21 January 2018

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The clinical and biological relationship between Type II diabetes mellitus and Alzheimer's disease

21 January 2018

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Common mechanisms of amyloid oligomer pathogenesis in degenerative disease

21 January 2018

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Conformational Abs recognizing a generic amyloid fibril epitope

21 January 2018

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Conformation-dependent anti-amyloid oligomer antibodies

21 January 2018

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The coexistence and differentiation of late onset Huntington's disease and Alzheimer's disease. A case report and review of the literature

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Apolipoprotein E increases the fibrillogenic potential of synthetic peptides derived from Alzheimer's, Gelsolin and AA amyloids

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Molecular cross talk between misfolded proteins in animal models of Alzheimer's and prion diseases

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Lewy bodies in the amygdala: increase of alpha-synuclein aggregates in neurodegenerative diseases with tau-based inclusions

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Initiation and Synergistic Fibrillization of Tau and Alpha-Synuclein

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More than just two peas in a pod: common amyloidogenic properties of tau and alpha-synuclein in neurodegenerative diseases

21 January 2018

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Seeding specificity in amyloid growth induced by heterologous fibrils

21 January 2018

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Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

21 January 2018

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Mitochondrial and Cell Death Mechanisms in Neurodegenerative Diseases

21 January 2018

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Abeta and human amylin share a common toxicity pathway via mitochondrial dysfunction

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The role of metabolic disorders in Alzheimer disease and vascular dementia: two roads converged

21 January 2018

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Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease – is this type 3 diabetes?

21 January 2018

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The cerebral glucose-fatty acid cycle: evolutionary roots, regulation, and (patho)physiological importance

21 January 2018

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Involvement of astroglial ceramide in palmitic acid-induced Alzheimer-like changes in primary neurons

21 January 2018

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Increased neuronal glucose-6-phosphate dehydrogenase and sulfhydryl levels indicate reductive compensation to oxidative stress in Alzheimer disease.

21 January 2018

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Glucose metabolism and Alzheimer's disease

21 January 2018

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Increased cerebral glucose-6-phosphate dehydrogenase activity in Alzheimer's disease may reflect oxidative stress

21 January 2018

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Metabolic reconfiguration is a regulated response to oxidative stress.

21 January 2018

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Proteomic identification of HNE-bound proteins in early Alzheimer disease: Insights into the role of lipid peroxidation in the progression of AD.

21 January 2018

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Redox proteomics identification of oxidized proteins in Alzheimer's disease hippocampus and cerebellum: an approach to understand pathological and biochemical alterations in AD.

21 January 2018

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Altered mitochondria, energy metabolism, voltage-dependent anion channel, and lipid rafts converge to exhaust neurons in Alzheimer's disease

21 January 2018

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Roles of amyloid beta-peptide-associated oxidative stress and brain protein modifications in the pathogenesis of Alzheimer's disease and mild cognitive impairment

21 January 2018

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Identification of nitrated proteins in Alzheimer's disease brain using a redox proteomics approach

21 January 2018

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Oxidatively modified, mitochondria-relevant brain proteins in subjects with Alzheimer disease and mild cognitive impairment

21 January 2018

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Gene expression profiles of metabolic enzyme transcripts in Alzheimer's disease

21 January 2018

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Decrease of dehydrogenase activity of cerebral glyceraldehyde-3-phosphate dehydrogenase in different animal models of Alzheimer's disease

21 January 2018

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Proteins in human brain cortex are modified by oxidation, glycoxidation, and lipoxidation. Effects of Alzheimer disease and identification of lipoxidation targets.

21 January 2018

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Redox proteomics identification of 4-hydroxynonenal-modified brain proteins in Alzheimer's disease: Role of lipid peroxidation in Alzheimer's disease pathogenesis

21 January 2018

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Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part II: dihydropyrimidinase-related protein 2, alpha-enolase and heat shock cognate 71.

21 January 2018

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Epigenetic oxidative redox shift (EORS) theory of aging unifies the free radical and insulin signaling theories

21 January 2018

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Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice

21 January 2018

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Oxidative damage in Alzheimer's disease: the metabolic dimension

21 January 2018

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Mitochondrial abnormalities in Alzheimer brain: mechanistic implications

21 January 2018

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Oxidant-induced changes in mitochondria and calcium dynamics in the pathophysiology of Alzheimer's disease

21 January 2018

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Amyloid beta, mitochondrial structural and functional dynamics in Alzheimer's disease

21 January 2018

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The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology

21 January 2018

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Alzheimer's disease and cholesterol: the fat connection

21 January 2018

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https://api.crossref.org/works/10.1258%2FEBM.2011.010355

NADPH oxidases of the brain: distribution, regulation, and function

21 January 2018

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Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans

21 January 2018

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Ketones: Metabolism's Ugly Duckling

21 January 2018

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Alzheimer's proteins, oxidative stress, and mitochondrial dysfunction interplay in a neuronal model of Alzheimer's disease

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Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology

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Cause and consequence: mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative diseases.

21 January 2018

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Mitochondrial respiratory inhibition and oxidative stress elevate beta-secretase (BACE1) proteins and activity in vivo in the rat retina

21 January 2018

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beta-Amyloid neurotoxicity is exacerbated during glycolysis inhibition and mitochondrial impairment in the rat hippocampus in vivo and in isolated nerve terminals: implications for Alzheimer's disease

21 January 2018

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Energy inhibition elevates beta-secretase levels and activity and is potentially amyloidogenic in APP transgenic mice: possible early events in Alzheimer's disease pathogenesis.

21 January 2018

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Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis

21 January 2018

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Thiamine deficiency induces oxidative stress and exacerbates the plaque pathology in Alzheimer's mouse model

21 January 2018

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Oxidative stress increases expression and activity of BACE in NT2 neurons

21 January 2018

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Beta-site APP cleaving enzyme up-regulation induced by 4-hydroxynonenal is mediated by stress-activated protein kinases pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2011.010355

In vitro effect of quinolinic acid on energy metabolism in brain of young rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2011.010355

Metabolic reprogramming, caloric restriction and aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2011.010355

Cytochrome c oxidase deficiency in neurons decreases both oxidative stress and amyloid formation in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2011.010355

Metabolic links between diabetes and Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2011.010355

Insulin resistance is associated with the pathology of Alzheimer disease: the Hisayama study

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2011.010355

Increased food intake leads to obesity and insulin resistance in the tg2576 Alzheimer's disease mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2011.010355

High-fat diet aggravates amyloid-beta and tau pathologies in the 3xTg-AD mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2011.010355

Insulin-resistant brain state after intracerebroventricular streptozotocin injection exacerbates Alzheimer-like changes in Tg2576 AbetaPP-overexpressing mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2011.010355

Intake of sucrose-sweetened water induces insulin resistance and exacerbates memory deficits and amyloidosis in a transgenic mouse model of Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2011.010355

PPARs in Alzheimer's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2011.010355

Peroxisome proliferator-activated receptor gamma enhances the activity of an insulin degrading enzyme-like metalloprotease for amyloid-beta clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2011.010355

Rosiglitazone reversal of Tg2576 cognitive deficits is independent of peripheral gluco-regulatory status

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2011.010355

Inhibition of hexokinase leads to neuroprotection against excitotoxicity in organotypic hippocampal slice culture.

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2011.010355

Mitochondria are a major source of paraquat-induced reactive oxygen species production in the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2011.010355

Complex I: inhibitors, inhibition and neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2011.010355

3-nitropropionic acid is a suicide inhibitor of mitochondrial respiration that, upon oxidation by complex II, forms a covalent adduct with a catalytic base arginine in the active site of the enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2011.010355

In Situ Oxidative Catalysis by Neurofibrillary Tangles and Senile Plaques in Alzheimer’s Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1258%2FEBM.2011.010355

21 January 2018

Identifiers

DOI

10.1258/EBM.2011.010355

1 reference

31 July 2017

1 reference