The abundance and activation of mTORC1 regulators in skeletal muscle of neonatal pigs are modulated by insulin, amino acids, and age (Q34305303)

1 August 2017

title

The abundance and activation of mTORC1 regulators in skeletal muscle of neonatal pigs are modulated by insulin, amino acids, and age (English)

1 reference

10.1152/JAPPLPHYSIOL.00428.2010

DOI

https://api.crossref.org/works/10.1152/JAPPLPHYSIOL.00428.2010

19 June 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20724570

19 June 2024

author name string

Agus Suryawan

series ordinal

1

1 reference

1 August 2017

Teresa A. Davis

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20724570

19 June 2024

language of work or name

English

0 references

publication date

19 August 2010

1 reference

full work available at URL

1 August 2017

https://europepmc.org/articles/pmc2980373

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20724570

http://intl-jap.physiology.org/cgi/content/abstract/109/5/1448

19 June 2024

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20724570

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20724570/?tool=EBI

19 June 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20724570

https://europepmc.org/articles/PMC2980373

19 June 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20724570

https://doi.org/10.1152/japplphysiol.00428.2010

19 June 2024

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20724570

https://www.physiology.org/doi/pdf/10.1152/japplphysiol.00428.2010

19 June 2024

1 reference

10.1152/JAPPLPHYSIOL.00428.2010

DOI

https://api.crossref.org/works/10.1152/JAPPLPHYSIOL.00428.2010

Journal of Applied Physiology

19 June 2024

published in

1 reference

1 August 2017

volume

109

1 reference

1 August 2017

issue

5

1 reference

1 August 2017

page(s)

1448-1454

1 reference

Reassessment of the role of FKBP38 in the Rheb/mTORC1 pathway

1 August 2017

cites work

1 reference

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Regulation of muscle growth in neonates

6 July 2018

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mVps34 is activated following high-resistance contractions

6 July 2018

1 reference

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mTOR signaling: RAG GTPases transmit the amino acid signal

6 July 2018

1 reference

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mTOR signaling: PLD takes center stage

6 July 2018

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Leucine stimulates protein synthesis in skeletal muscle of neonatal pigs by enhancing mTORC1 activation

6 July 2018

1 reference

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Re-evaluating the roles of proposed modulators of mammalian target of rapamycin complex 1 (mTORC1) signaling

6 July 2018

1 reference

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The switch I region of Rheb is critical for its interaction with FKBP38.

6 July 2018

1 reference

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Regulation of TORC1 by Rag GTPases in nutrient response

6 July 2018

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Phospholipase D1 is an effector of Rheb in the mTOR pathway.

6 July 2018

1 reference

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The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

6 July 2018

1 reference

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The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila.

6 July 2018

1 reference

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Amino acids activate mTOR complex 1 via Ca2+/CaM signaling to hVps34.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2980373

AMPK phosphorylation of raptor mediates a metabolic checkpoint

6 July 2018

1 reference

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Regulation of proline-rich Akt substrate of 40 kDa (PRAS40) function by mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation

6 July 2018

1 reference

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6 July 2018

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6 July 2018

1 reference

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Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2980373

Amino acids and mTOR signalling in anabolic function

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2980373

Activation by insulin and amino acids of signaling components leading to translation initiation in skeletal muscle of neonatal pigs is developmentally regulated

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2980373

PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2980373

The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2980373

The Rheb switch 2 segment is critical for signaling to target of rapamycin complex 1.

6 July 2018

1 reference

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Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2980373

Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1

6 July 2018

1 reference

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Upstream of the mammalian target of rapamycin: do all roads pass through mTOR?

6 July 2018

1 reference

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mTOR and cancer: insights into a complex relationship

6 July 2018

1 reference

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hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase

6 July 2018

1 reference

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Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency

6 July 2018

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6 July 2018

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Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function

6 July 2018

1 reference

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mTOR integrates amino acid- and energy-sensing pathways

6 July 2018

1 reference

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6 July 2018

1 reference

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6 July 2018

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6 July 2018

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Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

6 July 2018

1 reference

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Insulin-activated protein kinase Cbeta bypasses Ras and stimulates mitogen-activated protein kinase activity and cell proliferation in muscle cells.

6 July 2018

1 reference

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Phosphorylation and activation of phospholipase D1 by protein kinase C in vivo: determination of multiple phosphorylation sites

6 July 2018

1 reference

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Protein synthesis in skeletal muscle and jejunum is more responsive to feeding in 7-than in 26-day-old pigs.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2980373

Leucine metabolism in human newborns.

6 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2980373

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2980373

Stimulation of protein synthesis by both insulin and amino acids is unique to skeletal muscle in neonatal pigs

6 July 2018

1 reference

https://api.crossref.org/works/10.1152%2FJAPPLPHYSIOL.00428.2010

Developmental changes in the feeding-induced stimulation of translation initiation in muscle of neonatal pigs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FJAPPLPHYSIOL.00428.2010

Glucose stimulates protein synthesis in skeletal muscle of neonatal pigs through an AMPK- and mTOR-independent process

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FJAPPLPHYSIOL.00428.2010

In rat hepatocytes glucagon increases mammalian target of rapamycin phosphorylation on serine 2448 but antagonizes the phosphorylation of its downstream targets induced by insulin and amino acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FJAPPLPHYSIOL.00428.2010

Cell signaling. mTOR, unleashed

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FJAPPLPHYSIOL.00428.2010

Activation of the cardiac mTOR/p70(S6K) pathway by leucine requires PDK1 and correlates with PRAS40 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FJAPPLPHYSIOL.00428.2010

Developmental changes in the feeding-induced activation of the insulin-signaling pathway in neonatal pigs

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FJAPPLPHYSIOL.00428.2010

Regulation of class III (Vps34) PI3Ks

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FJAPPLPHYSIOL.00428.2010

Amino acids do not alter the insulin-induced activation of the insulin signaling pathway in neonatal pigs

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20724570

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Protein turnover in skeletal muscle of suckling rats

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20724570

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1152/JAPPLPHYSIOL.00428.2010

1 reference

1 August 2017

1 reference

1 August 2017

1 reference