Unlocking the potential of the human genome with RNA interference (Q34348958)

1 August 2017

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title

Unlocking the potential of the human genome with RNA interference (English)

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1 August 2017

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1

Gregory J Hannon

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1 August 2017

John J Rossi

2

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1 August 2017

language of work or name

English

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publication date

1 September 2004

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1 August 2017

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1 August 2017

volume

431

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1 August 2017

issue

7006

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1 August 2017

page(s)

371-378

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par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed

1 August 2017

cites work

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https://api.crossref.org/works/10.1038%2FNATURE02870

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE02870

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

Role of the double-stranded RNA-activated protein kinase (PKR) in cell regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

Role for a bidentate ribonuclease in the initiation step of RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

Argonaute2, a link between genetic and biochemical analyses of RNAi

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE02870

Functional siRNAs and miRNAs Exhibit Strand Bias

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

Asymmetry in the assembly of the RNAi enzyme complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

Rational siRNA design for RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

Identification of Modulators of TRAIL-Induced Apoptosis via RNAi-Based Phenotypic Screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

Determinants of interferon-stimulated gene induction by RNAi vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

Nonspecific, concentration-dependent stimulation and repression of mammalian gene expression by small interfering RNAs (siRNAs).

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE02870

Activation of the interferon system by short-interfering RNAs

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE02870

Interferon induction by siRNAs and ssRNAs synthesized by phage polymerase

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE02870

Expression profiling reveals off-target gene regulation by RNAi

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

Specificity of microRNA target selection in translational repression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

Computational identification of Drosophila microRNA genes

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE02870

Prediction of mammalian microRNA targets

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE02870

MicroRNA targets in Drosophila

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE02870

Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE02870

RNA interference in adult mice.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE02870

Electroporation and RNA interference in the rodent retina in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

In vivo activity of nuclease-resistant siRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

Stable suppression of tumorigenicity by virus-mediated RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

Germline transmission of RNAi in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

A general method for gene knockdown in mice by using lentiviral vectors expressing small interfering RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

Small interfering RNA and gene silencing in transgenic mice and rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

Transgenic RNA interference in ES cell-derived embryos recapitulates a genetic null phenotype.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE02870

A library of siRNA duplexes targeting the phosphoinositide 3-kinase pathway: determinants of gene silencing for use in cell-based screens

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

A large-scale RNAi screen in human cells identifies new components of the p53 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

A resource for large-scale RNA-interference-based screens in mammals.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

An approach to genomewide screens of expressed small interfering RNAs in mammalian cells.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE02870

Small interfering RNA production by enzymatic engineering of DNA (SPEED)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

Enzymatic production of RNAi libraries from cDNAs.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE02870

Restriction enzyme-generated siRNA (REGS) vectors and libraries

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE02870

RNA interference microarrays: high-throughput loss-of-function genetics in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

Microarrays of cells expressing defined cDNAs

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE02870

Modulation of HIV-1 replication by RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

Cloned zebrafish by nuclear transfer from long-term-cultured cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

Potent and specific inhibition of human immunodeficiency virus type 1 replication by RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

RNA interference directed against viral and cellular targets inhibits human immunodeficiency Virus Type 1 replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

Prevention of HIV-1 infection in human peripheral blood mononuclear cells by specific RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

Human immunodeficiency virus type 1 escape from RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

Inhibition of HIV-1 infection by small interfering RNA-mediated RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

Inhibition of HIV-1 by lentiviral vector-transduced siRNAs in T lymphocytes differentiated in SCID-hu mice and CD34+ progenitor cell-derived macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

Inhibition of HIV-1 infection by lentiviral vectors expressing Pol III-promoted anti-HIV RNAs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

In vivo selection for human and murine hematopoietic cells transduced with a therapeutic MGMT lentiviral vector that inhibits HIV replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

Anti-human immunodeficiency virus hematopoietic progenitor cell-delivered ribozyme in a phase I study: myeloid and lymphoid reconstitution in human immunodeficiency virus type-1-infected patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

RNA-mediated inhibition of HIV in a gene therapy setting

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

Inhibition of hepatitis B virus in mice by RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

Efficient initiation of HCV RNA replication in cell culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

Selectable subgenomic and genome-length dicistronic RNAs derived from an infectious molecular clone of the HCV-N strain of hepatitis C virus replicate efficiently in cultured Huh7 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

Characterization of cell lines carrying self-replicating hepatitis C virus RNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

Clearance of replicating hepatitis C virus replicon RNAs in cell culture by small interfering RNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

RNA interference blocks gene expression and RNA synthesis from hepatitis C replicons propagated in human liver cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

Interference of hepatitis C virus RNA replication by short interfering RNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

Development of catheter-based procedures for transducing the isolated rabbit liver with plasmid DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

RNA interference: gene silencing in the fast lane

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

Small RNA: can RNA interference be exploited for therapy?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

siRNA function in RNAi: a chemical modification analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

Structural variations and stabilising modifications of synthetic siRNAs in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

Progress in the delivery of therapeutic oligonucleotides: organ/cellular distribution and targeted delivery of oligonucleotides in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

Effect of imatinib mesylate on chronic myelogenous leukemia hematopoietic progenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

Molecular mechanisms of resistance of leukemia to imatinib mesylate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

Imatinib (STI571) resistance in chronic myelogenous leukemia: molecular basis of the underlying mechanisms and potential strategies for treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

Specific killing of Ph+ chronic myeloid leukemia cells by a lentiviral vector-delivered anti-bcr/abl small hairpin RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

Inhibition of bcr-abl gene expression by small interfering RNA sensitizes for imatinib mesylate (STI571).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

Specific inhibition of bcr-abl gene expression by small interfering RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

Targeting Alzheimer's disease genes with RNA interference: an efficient strategy for silencing mutant alleles

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

Allele-specific silencing of dominant disease genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

Selective silencing by RNAi of a dominant allele that causes amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

Molecular medicine for the brain: silencing of disease genes with RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

MicroRNAs: deviants no longer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

MicroRNAs: hidden in the genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

Sequence-specific inhibition of small RNA function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

Small RNAs with imperfect match to endogenous mRNA repress translation. Implications for off-target activity of small inhibitory RNA in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

Heterozygosity for a deletion in the CKR-5 gene leads to prolonged AIDS-free survival and slower CD4 T-cell decline in a cohort of HIV-seropositive individuals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

Free energy lights the path toward more effective RNAi

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

7 January 2021

Efficient delivery of siRNA for inhibition of gene expression in postnatal mice

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

7 January 2021

Gene silencing by systemic delivery of synthetic siRNAs in adult mice

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

7 January 2021

An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

7 January 2021

Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cells

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

7 January 2021

siRNA-directed inhibition of HIV-1 infection

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

7 January 2021

Suppression of chemokine receptor expression by RNA interference allows for inhibition of HIV-1 replication

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

7 January 2021

In vitro and in vivo hematopoietic potential of human stem cells residing in muscle tissue

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

7 January 2021

Lentivirus in the clinic

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

7 January 2021

RNA interference targeting Fas protects mice from fulminant hepatitis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02870

7 January 2021

Identifiers

DOI

10.1038/NATURE02870

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Dimensions Publication ID

1 August 2017

1017874357

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