An examination of wild-type SOD1 in modulating the toxicity and aggregation of ALS-associated mutant SOD1 (Q34341120)

1 August 2017

title

An examination of wild-type SOD1 in modulating the toxicity and aggregation of ALS-associated mutant SOD1 (English)

1 reference

amyotrophic lateral sclerosis

1 August 2017

main subject

1 reference

0 references

3

Julian P Whitelegge

1 reference

1 August 2017

1

Mercedes Prudencio

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20871097

20 July 2024

author name string

Armando Durazo

series ordinal

2

1 reference

1 August 2017

David R. Borchelt

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20871097

20 July 2024

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=20871097

20 July 2024

publication date

24 September 2010

1 reference

full work available at URL

1 August 2017

https://academic.oup.com/hmg/article-pdf/19/24/4774/17249971/ddq408.pdf

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20871097

http://hmg.oxfordjournals.org/cgi/content/abstract/19/24/4774

20 July 2024

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20871097

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20871097/?tool=EBI

20 July 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20871097

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20871097/pdf/?tool=EBI

20 July 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20871097

https://europepmc.org/articles/PMC2989888

20 July 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20871097

https://europepmc.org/articles/PMC2989888?pdf=render

20 July 2024

online access status

open access

content deliverer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20871097

http://academic.oup.com/hmg/article-pdf/19/24/4774/17249971/ddq408.pdf

20 July 2024

https://api.crossref.org/works/10.1093/HMG/DDQ408

1 reference

20 July 2024

published in

Human Molecular Genetics

1 reference

1 August 2017

volume

19

1 reference

1 August 2017

issue

24

1 reference

1 August 2017

page(s)

4774-4789

1 reference

An examination of alpha B-crystallin as a modifier of SOD1 aggregate pathology and toxicity in models of familial amyotrophic lateral sclerosis.

1 August 2017

cites work

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Wild-type Cu/Zn superoxide dismutase (SOD1) does not facilitate, but impedes the formation of protein aggregates of amyotrophic lateral sclerosis causing mutant SOD1.

6 July 2018

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Variation in aggregation propensities among ALS-associated variants of SOD1: correlation to human disease.

6 July 2018

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Role of mutant SOD1 disulfide oxidation and aggregation in the pathogenesis of familial ALS

6 July 2018

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Wild-type SOD1 overexpression accelerates disease onset of a G85R SOD1 mouse.

6 July 2018

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6 July 2018

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Initiation and elongation in fibrillation of ALS-linked superoxide dismutase

6 July 2018

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Protein aggregation and protein instability govern familial amyotrophic lateral sclerosis patient survival

6 July 2018

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Molecular dissection of ALS-associated toxicity of SOD1 in transgenic mice using an exon-fusion approach.

6 July 2018

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A limited role for disulfide cross-linking in the aggregation of mutant SOD1 linked to familial amyotrophic lateral sclerosis.

6 July 2018

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Heterodimer formation of wild-type and amyotrophic lateral sclerosis-causing mutant Cu/Zn-superoxide dismutase induces toxicity independent of protein aggregation

6 July 2018

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Protein aggregation processes: In search of the mechanism

6 July 2018

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Soluble misfolded subfractions of mutant superoxide dismutase-1s are enriched in spinal cords throughout life in murine ALS models

6 July 2018

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Disease-associated mutations at copper ligand histidine residues of superoxide dismutase 1 diminish the binding of copper and compromise dimer stability

6 July 2018

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Conversion to the amyotrophic lateral sclerosis phenotype is associated with intermolecular linked insoluble aggregates of SOD1 in mitochondria

6 July 2018

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Principles of protein folding, misfolding and aggregation

6 July 2018

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Aggregation and Motor Neuron Toxicity of an ALS-Linked SOD1 Mutant Independent from Wild-Type SOD1

6 July 2018

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Homozygosity for Asn86Ser mutation in the CuZn-superoxide dismutase gene produces a severe clinical phenotype in a juvenile onset case of familial amyotrophic lateral sclerosis

6 July 2018

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Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

6 July 2018

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Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation

6 July 2018

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Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity

6 July 2018

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Superoxide dismutase is an abundant component in cell bodies, dendrites, and axons of motor neurons and in a subset of other neurons

6 July 2018

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Superoxide dismutase 1 subunits with mutations linked to familial amyotrophic lateral sclerosis do not affect wild-type subunit function.

6 July 2018

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Copper-binding-site-null SOD1 causes ALS in transgenic mice: aggregates of non-native SOD1 delineate a common feature

6 July 2018

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An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria

21 January 2018

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High molecular weight complexes of mutant superoxide dismutase 1: age-dependent and tissue-specific accumulation

21 January 2018

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An intersubunit disulfide bond prevents in vitro aggregation of a superoxide dismutase-1 mutant linked to familial amytrophic lateral sclerosis

21 January 2018

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D90A heterozygosity in the SOD1 gene is associated with familial and apparently sporadic amyotrophic lateral sclerosis

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Marked reduction of the Cu/Zn superoxide dismutase polypeptide in a case of familial amyotrophic lateral sclerosis with the homozygous mutation

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12 December 2020

Amyotrophic lateral sclerosis associated with homozygosity for an Asp90Ala mutation in CuZn-superoxide dismutase

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12 December 2020

Somatodendritic accumulation of misfolded SOD1-L126Z in motor neurons mediates degeneration: alphaB-crystallin modulates aggregation

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12 December 2020

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Insoluble Mutant SOD1 Is Partly Oligoubiquitinated in Amyotrophic Lateral Sclerosis Mice

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Wild-type superoxide dismutase acquires binding and toxic properties of ALS-linked mutant forms through oxidation

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Identifiers

DOI

10.1093/HMG/DDQ408

1 reference

1 August 2017

1 reference

1 August 2017

1 reference