Pharmacogenetics of irinotecan: An ethnicity-based prediction of irinotecan adverse events (Q34391234)

1 August 2017

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title

Pharmacogenetics of irinotecan: An ethnicity-based prediction of irinotecan adverse events (English)

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1 August 2017

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Shouji Shimoyama

1

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1 August 2017

publication date

1 January 2010

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World journal of gastrointestinal surgery

1 August 2017

published in

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1 August 2017

volume

2

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1 August 2017

issue

1

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1 August 2017

page(s)

14-21

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Pharmacogenetics of fluoropyrimidine and cisplatin. A future application to gastric cancer treatment

1 August 2017

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6 July 2018

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6 July 2018

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UGT1A1*6 polymorphism is most predictive of severe neutropenia induced by irinotecan in Japanese cancer patients.

27 October 2018

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Genetic testing for UGT1A1*28 and *6 in Japanese patients who receive irinotecan chemotherapy.

27 October 2018

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Importance of UDP-glucuronosyltransferase 1A1*6 for irinotecan toxicities in Japanese cancer patients

27 October 2018

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27 October 2018

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Pharmacogenetic impact of polymorphisms in the coding region of the UGT1A1 gene on SN-38 glucuronidation in Japanese patients with cancer.

27 October 2018

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Uridine diphosphate glucuronosyl transferase 1A1 promoter polymorphism predicts the risk of gastrointestinal toxicity and fatigue induced by irinotecan-based chemotherapy.

27 October 2018

1 reference

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Haplotypes of variants in the UDP-glucuronosyltransferase1A9 and 1A1 genes.

27 October 2018

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Genetic polymorphism in the phenobarbital-responsive enhancer module of the UDP-glucuronosyltransferase 1A1 gene and irinotecan toxicity

27 October 2018

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Identification and characterization of a functional TATA box polymorphism of the UDP glucuronosyltransferase 1A7 gene

27 October 2018

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UGT1A7 and UGT1A9 polymorphisms predict response and toxicity in colorectal cancer patients treated with capecitabine/irinotecan

27 October 2018

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Racial variability in haplotype frequencies of UGT1A1 and glucuronidation activity of a novel single nucleotide polymorphism 686C> T (P229L) found in an African-American

27 October 2018

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Genetic polymorphisms of bilirubin uridine diphosphate-glucuronosyltransferase gene in Japanese patients with Crigler-Najjar syndrome or Gilbert's syndrome as well as in healthy Japanese subjects.

27 October 2018

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Relevance of different UGT1A1 polymorphisms in irinotecan-induced toxicity: a molecular and clinical study of 75 patients

27 October 2018

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27 October 2018

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UGT1A1 haplotypes associated with reduced glucuronidation and increased serum bilirubin in irinotecan-administered Japanese patients with cancer

27 October 2018

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A novel polymorphism in the promoter region of human UGT1A9 gene (UGT1A9*22) and its effects on the transcriptional activity

27 October 2018

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27 October 2018

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The global distribution of length polymorphisms of the promoters of the glucuronosyltransferase 1 gene (UGT1A1): hematologic and evolutionary implications

27 October 2018

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Glucuronidation of 7-ethyl-10-hydroxycamptothecin (SN-38), an active metabolite of irinotecan (CPT-11), by human UGT1A1 variants, G71R, P229Q, and Y486D.

27 October 2018

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Identification of a defect in the UGT1A1 gene promoter and its association with hyperbilirubinemia

27 October 2018

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Frequencies of UDP-glucuronosyltransferase 1 (UGT1A1) gene promoter polymorphisms among distinct ethnic groups from Brazil

27 October 2018

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Relationship between development of diarrhea and the concentration of SN-38, an active metabolite of CPT-11, in the intestine and the blood plasma of athymic mice following intraperitoneal administration of CPT-11.

27 October 2018

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Cancer incidence and mortality in Europe, 2004

27 October 2018

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Genetic polymorphisms of UGT1A6 in a Japanese population

9 December 2018

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12 December 2020

UGT1A1 promoter genotype correlates with SN-38 pharmacokinetics, but not severe toxicity in patients receiving low-dose irinotecan

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Comprehensive analysis of UGT1A polymorphisms predictive for pharmacokinetics and treatment outcome in patients with non-small-cell lung cancer treated with irinotecan and cisplatin

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Genetic linkage of UGT1A7 and UGT1A9 polymorphisms to UGT1A1*6 is associated with reduced activity for SN-38 in Japanese patients with cancer

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12 December 2020

Comprehensive UGT1A1 genotyping in a Japanese population by pyrosequencing

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12 December 2020

Variations of the bilirubin uridine-diphosphoglucuronosyl transferase 1A1 gene in healthy Taiwanese

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12 December 2020

The UGT1A1*28 allele is relatively rare in a Japanese population

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12 December 2020

Contribution of two missense mutations (G71R and Y486D) of the bilirubin UDP glycosyltransferase (UGT1A1) gene to phenotypes of Gilbert's syndrome and Crigler-Najjar syndrome type II

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12 December 2020

UDP-Glucuronosyltransferase 1A1 gene polymorphisms and total bilirubin levels in an ethnically diverse cohort of women

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12 December 2020

Irinotecan pharmacokinetics/pharmacodynamics and UGT1A genetic polymorphisms in Japanese: roles of UGT1A1*6 and *28

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12 December 2020

UGT1A1*28 genotype and irinotecan-induced neutropenia: dose matters

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12 December 2020

Phase I and pharmacokinetic study of the camptothecin derivative irinotecan, administered on a weekly schedule in cancer patients

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12 December 2020

Identifiers

DOI

10.4240/WJGS.V2.I1.14

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1 August 2017

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1 August 2017

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