TOR and ageing: a complex pathway for a complex process. (Q34402682)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21115526%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

review article

1 reference

title

TOR and ageing: a complex pathway for a complex process (English)

1 reference

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17 January 2020

3

1 reference

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17 January 2020

author name string

Mark A McCormick

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21115526%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Shih-Yin Tsai

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21115526%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

language of work or name

English

0 references

publication date

1 January 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21115526%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

number of pages

11

1 reference

Philosophical Transactions of the Royal Society B

inferred from page(s)

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21115526%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

volume

366

1 reference

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17 January 2020

issue

1561

1 reference

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17 January 2020

page(s)

17-27

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21115526%20AND%20SRC:MED&resulttype=core&format=json

Dynamic switch of negative feedback regulation in Drosophila Akt-TOR signaling

17 January 2020

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1 reference

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Aging: Dial M for Mitochondria

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Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies

6 July 2018

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Extension of chronological life span by reduced TOR signaling requires down-regulation of Sch9p and involves increased mitochondrial OXPHOS complex density

6 July 2018

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6 July 2018

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6 July 2018

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Tor directly controls the Atg1 kinase complex to regulate autophagy

6 July 2018

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Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila

6 July 2018

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mTOR signaling at a glance

6 July 2018

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Deleting the 14-3-3 protein Bmh1 extends life span in Saccharomyces cerevisiae by increasing stress response

6 July 2018

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4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila

6 July 2018

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Ribosomal protein S6 kinase 1 signaling regulates mammalian life span

6 July 2018

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The Vam6 GEF controls TORC1 by activating the EGO complex

6 July 2018

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The HIF-1 hypoxia-inducible factor modulates lifespan in C. elegans

6 July 2018

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d4eBP acts downstream of both dTOR and dFoxo to modulate cardiac functional aging in Drosophila

6 July 2018

1 reference

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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

6 July 2018

1 reference

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The TOR pathway comes of age

6 July 2018

1 reference

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The coordination of nuclear and mitochondrial communication during aging and calorie restriction

6 July 2018

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HIF-1 modulates dietary restriction-mediated lifespan extension via IRE-1 in Caenorhabditis elegans

6 July 2018

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Understanding the Warburg effect: the metabolic requirements of cell proliferation

6 July 2018

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Autophagy is required for extension of yeast chronological life span by rapamycin

6 July 2018

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Nutrient control of TORC1, a cell-cycle regulator

6 July 2018

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Proteasomal regulation of the hypoxic response modulates aging in C. elegans

6 July 2018

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Molecular mechanisms of mTOR-mediated translational control

6 July 2018

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Sfp1 interaction with TORC1 and Mrs6 reveals feedback regulation on TOR signaling

6 July 2018

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A molecular mechanism of chronological aging in yeast.

6 July 2018

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Autophagy and amino acid homeostasis are required for chronological longevity in Saccharomyces cerevisiae

6 July 2018

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mTOR and the control of whole body metabolism

6 July 2018

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Rictor/TORC2 regulates Caenorhabditis elegans fat storage, body size, and development through sgk-1

6 July 2018

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Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans

6 July 2018

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Not all substrates are treated equally: implications for mTOR, rapamycin-resistance and cancer therapy

6 July 2018

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Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans

6 July 2018

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Caloric restriction and aging: studies in mice and monkeys

6 July 2018

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Autophagy and aging: keeping that old broom working

6 July 2018

1 reference

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Cancer cell metabolism: Warburg and beyond

6 July 2018

1 reference

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An RNA interference screen identifies a novel regulator of target of rapamycin that mediates hypoxia suppression of translation in Drosophila S2 cells.

6 July 2018

1 reference

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Dietary composition specifies consumption, obesity, and lifespan in Drosophila melanogaster

6 July 2018

1 reference

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Increased respiration in the sch9Delta mutant is required for increasing chronological life span but not replicative life span

6 July 2018

1 reference

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Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4.

6 July 2018

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Quantitative evidence for conserved longevity pathways between divergent eukaryotic species

6 July 2018

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The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

6 July 2018

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A role for autophagy in the extension of lifespan by dietary restriction in C. elegans

6 July 2018

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Life span extension by calorie restriction depends on Rim15 and transcription factors downstream of Ras/PKA, Tor, and Sch9

6 July 2018

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Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling

6 July 2018

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The biology of cancer: metabolic reprogramming fuels cell growth and proliferation

6 July 2018

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New modes of translational control in development, behavior, and disease

6 July 2018

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mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex

6 July 2018

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MSN2 and MSN4 link calorie restriction and TOR to sirtuin-mediated lifespan extension in Saccharomyces cerevisiae.

6 July 2018

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An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans

6 July 2018

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Calorie restriction extends the chronological lifespan of Saccharomyces cerevisiae independently of the Sirtuins

6 July 2018

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Rethinking the mitochondrial theory of aging: the role of mitochondrial gene expression in lifespan determination

6 July 2018

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6 July 2018

The two TORCs and Akt.

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Role of insulin-like signalling in Drosophila lifespan

6 July 2018

1 reference

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Reduced TOR signaling extends chronological life span via increased respiration and upregulation of mitochondrial gene expression

6 July 2018

1 reference

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Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans

6 July 2018

1 reference

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Direct induction of autophagy by Atg1 inhibits cell growth and induces apoptotic cell death

6 July 2018

1 reference

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Dietary deprivation extends lifespan in Caenorhabditis elegans

6 July 2018

1 reference

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Regulation of ribosome biogenesis: where is TOR?

6 July 2018

1 reference

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The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity

6 July 2018

1 reference

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Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance

6 July 2018

1 reference

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Rim15 and the crossroads of nutrient signalling pathways in Saccharomyces cerevisiae

6 July 2018

1 reference

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Extension of chronological life span in yeast by decreased TOR pathway signaling

6 July 2018

1 reference

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Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer

6 July 2018

1 reference

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Regulation of G0 entry by the Pho80-Pho85 cyclin-CDK complex.

6 July 2018

1 reference

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Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients

6 July 2018

1 reference

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Sir2 blocks extreme life-span extension.

6 July 2018

1 reference

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The insulin-PI3K/TOR pathway induces a HIF-dependent transcriptional response in Drosophila by promoting nuclear localization of HIF-alpha/Sima

6 July 2018

1 reference

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Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.

6 July 2018

1 reference

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The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila

6 July 2018

1 reference

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Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

6 July 2018

1 reference

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Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development

6 July 2018

1 reference

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6 July 2018

Putting the rap on Akt.

1 reference

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Superoxide is a mediator of an altruistic aging program in Saccharomyces cerevisiae

6 July 2018

1 reference

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Upstream and downstream of mTOR

6 July 2018

1 reference

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Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001303

Programmed autophagy in the Drosophila fat body is induced by ecdysone through regulation of the PI3K pathway

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001303

Role and regulation of starvation-induced autophagy in the Drosophila fat body

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001303

mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001303

The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001303

Nicotinamide clearance by Pnc1 directly regulates Sir2-mediated silencing and longevity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001303

TOR and PKA signaling pathways converge on the protein kinase Rim15 to control entry into G0.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001303

Genetics: influence of TOR kinase on lifespan in C. elegans

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001303

Autophagy genes are essential for dauer development and life-span extension in C. elegans

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001303

The chronological life span of Saccharomyces cerevisiae

6 July 2018

1 reference

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Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001303

Genetic analysis of insulin signaling in Drosophila

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001303

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001303

Regulation of longevity and stress resistance by Sch9 in yeast

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001303

Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001303

Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001303

Glucose limitation induces GCN4 translation by activation of Gcn2 protein kinase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001303

Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001303

The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001303

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001303

The genetics of caloric restriction in Caenorhabditis elegans

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001303

Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001303

daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001303

Female fitness in Drosophila melanogaster: an interaction between the effect of nutrition and of encounter rate with males.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001303

A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001303

The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001303

General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001303

A C. elegans mutant that lives twice as long as wild type

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001303

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001303

Impact of reduced insulin-like growth factor-1/insulin signaling on aging in mammals: novel findings.

6 July 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2010.0198

Axenic growth up-regulates mass-specific metabolic rate, stress resistance, and extends life span in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2010.0198

Lifespan extension in Caenorhabditis elegans by complete removal of food

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2010.0198

RAG GTPases in nutrient-mediated TOR signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2010.0198

Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss.

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2010.0198

Ribosomal proteins Rpl10 and Rps6 are potent regulators of yeast replicative life span.

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2010.0198

Autophagy regulates ageing in C. elegans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2010.0198

Inhibition of the p53-hdm2 interaction with low molecular weight compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2010.0198

Insights into the genome of large sulfur bacteria revealed by analysis of single filaments

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2010.0198

A method for high-throughput quantitative analysis of yeast chronological life span

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2010.0198

Hypoxic condition- and high cell density-induced expression of Redd1 is regulated by activation of hypoxia-inducible factor-1alpha and Sp1 through the phosphatidylinositol 3-kinase/Akt signaling pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2010.0198

Prime-numbered Atg proteins act at the primary step in autophagy: unphosphorylatable Atg13 can induce autophagy without TOR inactivation

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001303

Insulin/IGF-I and related signaling pathways regulate aging in nondividing cells: from yeast to the mammalian brain.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001303

The novel yeast PAS kinase Rim 15 orchestrates G0-associated antioxidant defense mechanisms

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001303

S6 kinase inactivation impairs growth and translational target phosphorylation in muscle cells maintaining proper regulation of protein turnover

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001303

An intervention resembling caloric restriction prolongs life span and retards aging in yeast

9 December 2018

1 reference

12 December 2020

Phosphorylation of ribosomal protein S6 is inhibitory for autophagy in isolated rat hepatocytes

1 reference

12 December 2020

Alterations of life span in the nematode Caenorhabditis elegans under monoxenic culture conditions

1 reference

12 December 2020

1 reference

12 December 2020

The hypoxic response and aging

1 reference

12 December 2020

Identifiers

DOI

10.1098/RSTB.2010.0198

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21115526%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21115526%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

PubMed publication ID

21115526

1 reference