Obligate roles for p16(Ink4a) and p19(Arf)-p53 in the suppression of murine pancreatic neoplasia (Q34440754)

2 August 2017

title

Obligate roles for p16(Ink4a) and p19(Arf)-p53 in the suppression of murine pancreatic neoplasia (English)

1 reference

2 August 2017

1

Nabeel Bardeesy

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Massimo Loda

6

object named as

Massimo Loda

1 reference

2 August 2017

8

Ronald A DePinho

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2 August 2017

4

Sabina Signoretti

1 reference

2 August 2017

Jeffrey Morgan

2

1 reference

2 August 2017

Manisha Sinha

3

1 reference

2 August 2017

Shefali Srivastava

5

1 reference

2 August 2017

Glenn Merlino

7

1 reference

2 August 2017

language of work or name

English

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publication date

1 January 2002

1 reference

Molecular and Cellular Biology

2 August 2017

published in

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2 August 2017

volume

22

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2 August 2017

issue

2

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2 August 2017

page(s)

635-643

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The p14ARF tumor suppressor protein facilitates nucleolar sequestration of hypoxia-inducible factor-1alpha (HIF-1alpha ) and inhibits HIF-1-mediated transcription

2 August 2017

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6 July 2018

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6 July 2018

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6 July 2018

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Cdkn2a encodes functional variation of p16INK4a but not p19ARF, which confers selection in mouse lung tumorigenesis

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

6 July 2018

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p19(Arf) induces p53-dependent apoptosis during abelson virus-mediated pre-B cell transformation

6 July 2018

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The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

6 July 2018

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E1A signaling to p53 involves the p19(ARF) tumor suppressor

6 July 2018

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Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

6 July 2018

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6 July 2018

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beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes

6 July 2018

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The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

6 July 2018

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Cdkn2a, the cyclin-dependent kinase inhibitor encoding p16INK4a and p19ARF, is a candidate for the plasmacytoma susceptibility locus, Pctr1.

6 July 2018

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p16INK4A participates in a G1 arrest checkpoint in response to DNA damage

6 July 2018

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Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

6 July 2018

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Cyclin E and c-Myc promote cell proliferation in the presence of p16INK4a and of hypophosphorylated retinoblastoma family proteins.

6 July 2018

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Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands

6 July 2018

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Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

6 July 2018

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A cell cycle regulator potentially involved in genesis of many tumor types

6 July 2018

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p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens.

6 July 2018

1 reference

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Insulin-promoter-factor 1 is required for pancreas development in mice

6 July 2018

1 reference

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Tumor spectrum analysis in p53-mutant mice

6 July 2018

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TGF alpha overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas

6 July 2018

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Cystic tumors of the pancreas. New clinical, radiologic, and pathologic observations in 67 patients

6 July 2018

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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

6 July 2018

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Hypertrophic gastropathy resembling Ménétrier's disease in transgenic mice overexpressing transforming growth factor alpha in the stomach

6 July 2018

1 reference

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Cytological changes in the pancreas of transgenic mice overexpressing transforming growth factor alpha

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139752

Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis

6 July 2018

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Expansion of Pdx1-expressing pancreatic epithelium and islet neogenesis in transgenic mice overexpressing transforming growth factor alpha.

27 October 2018

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The p16INK4a/CDKN2A tumor suppressor and its relatives.

27 October 2018

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Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells.

27 October 2018

1 reference

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Role of the INK4a locus in tumor suppression and cell mortality.

27 October 2018

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Tumor suppressor protein VHL is induced at high cell density and mediates contact inhibition of cell growth

27 October 2018

1 reference

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Transforming growth factor alpha disrupts the normal program of cellular differentiation in the gastric mucosa of transgenic mice

9 December 2018

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12 December 2020

Developmental biology of the pancreas

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12 December 2020

Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers

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12 December 2020

Transforming growth factor alpha is a target for the von Hippel-Lindau tumor suppressor

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12 December 2020

The homeodomain protein IDX-1 increases after an early burst of proliferation during pancreatic regeneration

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12 December 2020

Ductal metaplasia of human exocrine pancreas and its association with carcinoma

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12 December 2020

Overexpression of TGFα in transgenic mice: Induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast

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12 December 2020

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12 December 2020

The importance of the centroacinar region in cerulein-induced mouse pancreatic growth

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12 December 2020

10.1128/MCB.22.2.635-643.2002

Identifiers

DOI

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2 August 2017

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2 August 2017

1 reference