Pharmacological inhibition of O-GlcNAcase (OGA) prevents cognitive decline and amyloid plaque formation in bigenic tau/APP mutant mice. (Q34515333)

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21 February 2020

title

Pharmacological inhibition of O-GlcNAcase (OGA) prevents cognitive decline and amyloid plaque formation in bigenic tau/APP mutant mice (English)

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5

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Michael A. Silverman

9

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21 February 2020

David J Vocadlo

12

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10

Neil V Watson

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author name string

Scott A Yuzwa

1

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21 February 2020

Xiaoyang Shan

2

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Bryan A Jones

3

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Gang Zhao

4

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Xiaojing Li

6

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21 February 2020

Yanping Zhu

7

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Ernest J McEachern

8

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Cheng-Xin Gong

11

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21 February 2020

publication date

26 October 2014

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Molecular Neurodegeneration

21 February 2020

published in

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volume

9

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page(s)

42

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describes a project that uses

21 February 2020

ImageJ

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11 June 2022

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based on heuristic

inferred from PubMed Central ID database lookup

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Decreased glucose transporters correlate to abnormal hyperphosphorylation of tau in Alzheimer disease

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An inhibitor of tau hyperphosphorylation prevents severe motor impairments in tau transgenic mice

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Distinct transcriptional regulation and function of the human BACE2 and BACE1 genes

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Degradation of BACE by the ubiquitin-proteasome pathway

7 July 2018

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O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease

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Purification and characterization of an O-GlcNAc selective N-acetyl-beta-D-glucosaminidase from rat spleen cytosol.

7 July 2018

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7 July 2018

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The purification of tau protein and the occurrence of two phosphorylation states of tau in brain

7 July 2018

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Recognition of Alzheimer paired helical filaments by monoclonal neurofilament antibodies is due to crossreaction with tau protein

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7 July 2018

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Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system. Role of hexosamine biosynthesis in the induction of insulin resistance

7 July 2018

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Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

7 July 2018

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Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the beta-amyloid precursor protein gene.

7 July 2018

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A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid

7 July 2018

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Increased O-GlcNAcylation reduces pathological tau without affecting its normal phosphorylation in a mouse model of tauopathy.

7 July 2018

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O-linked β-N-acetylglucosaminidase inhibitor attenuates β-amyloid plaque and rescues memory impairment

27 October 2018

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Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation.

27 October 2018

1 reference

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O-GlcNAcase catalyzes cleavage of thioglycosides without general acid catalysis

27 October 2018

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Multi-metric behavioral comparison of APPsw and P301L models for Alzheimer's disease: linkage of poorer cognitive performance to tau pathology in forebrain

27 October 2018

1 reference

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Accumulation of protein O-GlcNAc modification inhibits proteasomes in the brain and coincides with neuronal apoptosis in brain areas with high O-GlcNAc metabolism

27 October 2018

1 reference

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Localization of the O-GlcNAc transferase and O-GlcNAc-modified proteins in rat cerebellar cortex

27 October 2018

1 reference

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Evidence of a balance between phosphorylation and O-GlcNAc glycosylation of Tau proteins--a role in nuclear localization

27 October 2018

1 reference

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Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils

27 October 2018

1 reference

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Abnormalities of Energy Metabolism in Alzheimer's Disease Studied with PETa

27 October 2018

1 reference

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Topography and polypeptide distribution of terminal N-acetylglucosamine residues on the surfaces of intact lymphocytes. Evidence for O-linked GlcNAc

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25344697

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1186/1750-1326-9-42

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25344697%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

21 February 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25344697%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

PubMed publication ID

25344697

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25344697%20AND%20SRC:MED&resulttype=core&format=json