Target deconvolution techniques in modern phenotypic profiling. (Q34556513)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23337810%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

review article

1 reference

title

Target deconvolution techniques in modern phenotypic profiling (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23337810%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

1 reference

1

1 reference

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22 February 2020

2

Matthew Bogyo

1 reference

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22 February 2020

publication date

18 January 2013

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23337810%20AND%20SRC:MED&resulttype=core&format=json

Current Opinion in Chemical Biology

22 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23337810%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

volume

17

1 reference

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22 February 2020

issue

1

1 reference

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22 February 2020

page(s)

118-126

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23337810%20AND%20SRC:MED&resulttype=core&format=json

Use of phage display technology for the determination of the targets for small-molecule therapeutics

22 February 2020

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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Chemical informatics and target identification in a zebrafish phenotypic screen.

7 July 2018

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Bugs, drugs and chemical genomics

7 July 2018

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Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity

7 July 2018

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7 July 2018

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Thermodynamic analysis of protein-ligand interactions in complex biological mixtures using a shotgun proteomics approach

7 July 2018

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Drug target deconvolution by chemical proteomics

7 July 2018

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Two-step bioorthogonal activity-based proteasome profiling using copper-free click reagents: a comparative study

7 July 2018

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How were new medicines discovered?

7 July 2018

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The metabolic serine hydrolases and their functions in mammalian physiology and disease

7 July 2018

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Proteases as regulators of pathogenesis: examples from the Apicomplexa.

7 July 2018

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Chemical genetic screen identifies Toxoplasma DJ-1 as a regulator of parasite secretion, attachment, and invasion

7 July 2018

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From in silico target prediction to multi-target drug design: current databases, methods and applications

7 July 2018

1 reference

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Screening of protein-protein interaction modulators via sulfo-click kinetic target-guided synthesis

7 July 2018

1 reference

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A yeast-based screen reveals that sulfasalazine inhibits tetrahydrobiopterin biosynthesis.

7 July 2018

1 reference

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Identification of drug targets in vitro and in living cells by soluble-nanopolymer-based proteomics

7 July 2018

1 reference

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Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors

7 July 2018

1 reference

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Rational Design of Inhibitors and Activity-Based Probes Targeting Clostridium difficile Virulence Factor TcdB

7 July 2018

1 reference

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The identification of cellular targets of 17β estradiol using a lytic (T7) cDNA phage display approach

7 July 2018

1 reference

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Probing the proteasome cavity in three steps: bio-orthogonal photo-reactive suicide substrates

7 July 2018

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Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease

7 July 2018

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Functional studies of Plasmodium falciparum dipeptidyl aminopeptidase I using small molecule inhibitors and active site probes

7 July 2018

1 reference

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Activity-based protein profiling for biochemical pathway discovery in cancer

7 July 2018

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Use of activity-based probes to develop high throughput screening assays that can be performed in complex cell extracts.

7 July 2018

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Two-step labeling of endogenous enzymatic activities by Diels-Alder ligation

7 July 2018

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Biochemical target isolation for novices: affinity-based strategies

7 July 2018

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Quantitative proteomics approach for identifying protein-drug interactions in complex mixtures using protein stability measurements.

7 July 2018

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cDNA phage display as a novel tool to screen for cellular targets of chemical compounds

7 July 2018

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In silico directed chemical probing of the adenosine receptor family

7 July 2018

1 reference

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In situ click chemistry: probing the binding landscapes of biological molecules

7 July 2018

1 reference

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Identification of a primary target of thalidomide teratogenicity

7 July 2018

1 reference

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Rapid multilabel detection of geranylgeranylated proteins by using bioorthogonal ligation chemistry

7 July 2018

1 reference

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Terpestacin inhibits tumor angiogenesis by targeting UQCRB of mitochondrial complex III and suppressing hypoxia-induced reactive oxygen species production and cellular oxygen sensing

7 July 2018

1 reference

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RBBP9: a tumor-associated serine hydrolase activity required for pancreatic neoplasia

7 July 2018

1 reference

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Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis

7 July 2018

1 reference

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Predicting new molecular targets for known drugs

7 July 2018

1 reference

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Target profiling of small molecules by chemical proteomics

7 July 2018

1 reference

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The topology of drug-target interaction networks: implicit dependence on drug properties and target families

7 July 2018

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Using small molecules to dissect mechanisms of microbial pathogenesis

7 July 2018

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Design and synthesis of an all-in-one 3-(1,1-difluoroprop-2-ynyl)-3H-diazirin-3-yl functional group for photo-affinity labeling

7 July 2018

1 reference

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Revealing promiscuous drug-target interactions by chemical proteomics.

7 July 2018

1 reference

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A suite of activity-based probes for human cytochrome P450 enzymes

7 July 2018

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Multi-parameter phenotypic profiling: using cellular effects to characterize small-molecule compounds

7 July 2018

1 reference

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Portopulmonary hypertension: imatinib as a novel treatment and the Emory experience with this condition

7 July 2018

1 reference

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Identification of selective inhibitors of uncharacterized enzymes by high-throughput screening with fluorescent activity-based probes

7 July 2018

1 reference

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Functional Proteomic and Structural Insights into Molecular Recognition in the Nitrilase Family Enzymes † ‡

7 July 2018

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In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen

7 July 2018

1 reference

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Thermodynamic analysis of protein stability and ligand binding using a chemical modification- and mass spectrometry-based strategy

7 July 2018

1 reference

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Identification of proteases that regulate erythrocyte rupture by the malaria parasite Plasmodium falciparum

7 July 2018

1 reference

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Integrating high-content screening and ligand-target prediction to identify mechanism of action

7 July 2018

1 reference

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ChemBank: a small-molecule screening and cheminformatics resource database

7 July 2018

1 reference

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Tagging and detection strategies for activity-based proteomics.

7 July 2018

1 reference

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An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling

7 July 2018

1 reference

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Mechanism-based profiling of enzyme families

7 July 2018

1 reference

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Proteomic profiling of metalloprotease activities with cocktails of active-site probes

7 July 2018

1 reference

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DrugBank: a comprehensive resource for in silico drug discovery and exploration

7 July 2018

1 reference

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Probing protein structure by limited proteolysis.

7 July 2018

1 reference

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A three-hybrid approach to scanning the proteome for targets of small molecule kinase inhibitors

7 July 2018

1 reference

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Gleevec inhibits β-amyloid production but not Notch cleavage

7 July 2018

1 reference

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Drug receptor identification from multiple tissues using cellular-derived mRNA display libraries

7 July 2018

1 reference

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Drug discovery: a historical perspective

7 July 2018

1 reference

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RNA-peptide fusions for the in vitro selection of peptides and proteins

7 July 2018

1 reference

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A three-hybrid system for detecting small ligand-protein receptor interactions

7 July 2018

1 reference

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Chemotography for multi-target SAR analysis in the context of biological pathways

7 July 2018

1 reference

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Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes.

27 October 2018

1 reference

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Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe.

27 October 2018

1 reference

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Target identification using drug affinity responsive target stability (DARTS)

27 October 2018

1 reference

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An inhibitor of glutathione S-transferase omega 1 that selectively targets apoptotic cells

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23337810

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CBPA.2012.12.022

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23337810%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23337810%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

PubMed publication ID

23337810

1 reference