Phosphotyrosine-binding domains in signal transduction (Q34627225)

3 August 2017

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title

Phosphotyrosine-binding domains in signal transduction (English)

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3 August 2017

Michael B Yaffe

1

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3 August 2017

publication date

1 March 2002

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Nature Reviews Molecular Cell Biology

3 August 2017

published in

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3 August 2017

volume

3

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3 August 2017

issue

3

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3 August 2017

page(s)

177-186

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Modular peptide recognition domains in eukaryotic signaling

3 August 2017

cites work

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Signaling through scaffold, anchoring, and adaptor proteins

31 March 2020

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A noncatalytic domain conserved among cytoplasmic protein-tyrosine kinases modifies the kinase function and transforming activity of Fujinami sarcoma virus P130gag-fps

31 March 2020

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A conserved domain regulates interactions of the v-fps protein-tyrosine kinase with the host cell

31 March 2020

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N-terminal deletions in Rous sarcoma virus p60src: effects on tyrosine kinase and biological activities and on recombination in tissue culture with the cellular src gene

31 March 2020

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Identification of an amino terminal domain required for the transforming activity of the Rous sarcoma virus src protein

31 March 2020

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The Sequence of the Human Genome

31 March 2020

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Binding of SH2 domains of phospholipase C gamma 1, GAP, and Src to activated growth factor receptors

31 March 2020

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Binding of Transforming Protein, P47 gag-crk , to a Broad Range of Phosphotyrosine-containing Proteins

31 March 2020

1 reference

Identification of domains of the v-crk oncogene product sufficient for association with phosphotyrosine-containing proteins

31 March 2020

1 reference

The noncatalytic src homology region 2 segment of abl tyrosine kinase binds to tyrosine-phosphorylated cellular proteins with high affinity

31 March 2020

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Src homology region 2 domains direct protein-protein interactions in signal transduction

31 March 2020

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Oncogenes and signal transduction

31 March 2020

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A phosphatidylinositol-3 kinase binds to platelet-derived growth factor receptors through a specific receptor sequence containing phosphotyrosine

31 March 2020

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Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways

31 March 2020

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GTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor beta subunit

31 March 2020

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Tyrosines 1021 and 1009 are phosphorylation sites in the carboxy terminus of the platelet-derived growth factor receptor beta subunit and are required for binding of phospholipase C gamma and a 64-kilodalton protein, respectively

31 March 2020

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The 64-kDa protein that associates with the platelet-derived growth factor receptor beta subunit via Tyr-1009 is the SH2-containing phosphotyrosine phosphatase Syp

31 March 2020

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SH2 domains recognize specific phosphopeptide sequences

31 March 2020

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Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav

31 March 2020

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Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structures of the complexed and peptide-free forms

31 March 2020

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Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase

31 March 2020

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Crystal structure of the PI 3-kinase p85 amino-terminal SH2 domain and its phosphopeptide complexes

31 March 2020

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Crystal structures of the human p56lck SH2 domain in complex with two short phosphotyrosyl peptides at 1.0 A and 1.8 A resolution

31 March 2020

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Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition

31 March 2020

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A motif-based profile scanning approach for genome-wide prediction of signaling pathways

31 March 2020

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Protein modules and signalling networks

31 March 2020

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Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides

31 March 2020

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Recognition of a high-affinity phosphotyrosyl peptide by the Src homology-2 domain of p56lck

31 March 2020

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Investigation of phosphotyrosine recognition by the SH2 domain of the Src kinase

31 March 2020

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Calorimetric examination of high-affinity Src SH2 domain-tyrosyl phosphopeptide binding: dissection of the phosphopeptide sequence specificity and coupling energetics

31 March 2020

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Structural basis for specificity switching of the Src SH2 domain

31 March 2020

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The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM

31 March 2020

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mGrb10 interacts with Nedd4

31 March 2020

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Novel mode of ligand binding by the SH2 domain of the human XLP disease gene product SAP/SH2D1A

31 March 2020

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SH2 domain specificity and activity modified by a single residue

31 March 2020

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Phospholipase C-gamma 1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal

31 March 2020

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The platelet-derived growth factor beta receptor triggers multiple cytoplasmic signaling cascades that arrive at the nucleus as distinguishable inputs

31 March 2020

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Retention of PDGFR-beta function in mice in the absence of phosphatidylinositol 3'-kinase and phospholipase Cgamma signaling pathways

31 March 2020

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Positive and negative tissue-specific signaling by a nematode epidermal growth factor receptor

31 March 2020

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Developmental roles of HGF/SF and its receptor, the c-Met tyrosine kinase

31 March 2020

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Coupling Met to specific pathways results in distinct developmental outcomes

31 March 2020

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The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

31 March 2020

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A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

31 March 2020

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High-efficiency expression/cloning of epidermal growth factor-receptor-binding proteins with Src homology 2 domains

31 March 2020

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Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

31 March 2020

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A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos.

31 March 2020

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Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

31 March 2020

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Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

31 March 2020

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Identification of a putative Syp substrate, the PDGF beta receptor

31 March 2020

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Drosophila terminal structure development is regulated by the compensatory activities of positive and negative phosphotyrosine signaling sites on the Torso RTK.

31 March 2020

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Opposing actions of CSW and RasGAP modulate the strength of Torso RTK signaling in the Drosophila terminal pathway.

31 March 2020

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Tyrosine phosphorylation of the c-cbl proto-oncogene protein product and association with epidermal growth factor (EGF) receptor upon EGF stimulation

31 March 2020

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Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase

31 March 2020

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The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase

31 March 2020

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c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor

31 March 2020

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The evolutionarily conserved N-terminal region of Cbl is sufficient to enhance down-regulation of the epidermal growth factor receptor

31 March 2020

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The tyrosine kinase regulator Cbl enhances the ubiquitination and degradation of the platelet-derived growth factor receptor alpha

31 March 2020

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The RING finger of c-Cbl mediates desensitization of the epidermal growth factor receptor

31 March 2020

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Three-dimensional structure of the tyrosine kinase c-Src

31 March 2020

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Crystal structure of the Src family tyrosine kinase Hck

31 March 2020

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Crystal structures of c-Src reveal features of its autoinhibitory mechanism

31 March 2020

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Dynamic coupling between the SH2 and SH3 domains of c-Src and Hck underlies their inactivation by C-terminal tyrosine phosphorylation

31 March 2020

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Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement

31 March 2020

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Evidence that SH2 domains promote processive phosphorylation by protein-tyrosine kinases

31 March 2020

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Enhanced phosphorylation of Src family kinase substrates containing SH2 domain binding sites

31 March 2020

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A peptide model system for processive phosphorylation by Src family kinases

31 March 2020

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Spatial constraints on the recognition of phosphoproteins by the tandem SH2 domains of the phosphatase SH-PTP2

31 March 2020

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Tandem SH2 domains confer high specificity in tyrosine kinase signaling

31 March 2020

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Crystal structure of the tyrosine phosphatase SHP-2

31 March 2020

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Structural basis for Syk tyrosine kinase ubiquity in signal transduction pathways revealed by the crystal structure of its regulatory SH2 domains bound to a dually phosphorylated ITAM peptide

31 March 2020

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An alternative to SH2 domains for binding tyrosine-phosphorylated proteins

31 March 2020

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Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain

31 March 2020

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Structure and function of the phosphotyrosine binding (PTB) domain

31 March 2020

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SH2 and PTB domain interactions in tyrosine kinase signal transduction.

31 March 2020

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How and why phosphotyrosine-containing peptides bind to the SH2 and PTB domains

31 March 2020

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Diversity in protein recognition by PTB domains

31 March 2020

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The function of PTB domain proteins

31 March 2020

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Specificity of the PTB domain of Shc for beta turn-forming pentapeptide motifs amino-terminal to phosphotyrosine

31 March 2020

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A conserved amino-terminal Shc domain binds to phosphotyrosine motifs in activated receptors and phosphopeptides

31 March 2020

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Identification of residues that control specific binding of the Shc phosphotyrosine-binding domain to phosphotyrosine sites

31 March 2020

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PTB domains of IRS-1 and Shc have distinct but overlapping binding specificities

31 March 2020

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The phosphotyrosine interaction domain of SHC recognizes tyrosine-phosphorylated NPXY motif

31 March 2020

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Characterization of the phosphotyrosine-binding domain of the Drosophila Shc protein.

31 March 2020

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Affinity, specificity, and kinetics of the interaction of the SHC phosphotyrosine binding domain with asparagine-X-X-phosphotyrosine motifs of growth factor receptors

31 March 2020

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The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein

31 March 2020

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Sequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domain

31 March 2020

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The mammalian numb phosphotyrosine-binding domain. Characterization of binding specificity and identification of a novel PDZ domain-containing numb binding protein, LNX

31 March 2020

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Numb-associated kinase interacts with the phosphotyrosine binding domain of Numb and antagonizes the function of Numb in vivo

31 March 2020

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Structure of a Numb PTB domain-peptide complex suggests a basis for diverse binding specificity

31 March 2020

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Interaction of c-Jun amino-terminal kinase interacting protein-1 with p190 rhoGEF and its localization in differentiated neurons

31 March 2020

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Deletion of a conserved juxtamembrane sequence in Trk abolishes NGF-promoted neuritogenesis

31 March 2020

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The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation

31 March 2020

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Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins

31 March 2020

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FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors

31 March 2020

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Structure and ligand recognition of the phosphotyrosine binding domain of Shc

31 March 2020

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Structure of the IRS-1 PTB domain bound to the juxtamembrane region of the insulin receptor

31 March 2020

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Structural basis for IL-4 receptor phosphopeptide recognition by the IRS-1 PTB domain

31 March 2020

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Multiple modes of peptide recognition by the PTB domain of the cell fate determinant Numb

31 March 2020

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Structural basis of SNT PTB domain interactions with distinct neurotrophic receptors

31 March 2020

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Structure of the enabled/VASP homology 1 domain-peptide complex: a key component in the spatial control of actin assembly

31 March 2020

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Structure of EVH1, a novel proline-rich ligand-binding module involved in cytoskeletal dynamics and neural function

31 March 2020

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Signal-dependent membrane targeting by pleckstrin homology (PH) domains

31 March 2020

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Evidence for a requirement for both phospholipid and phosphotyrosine binding via the Shc phosphotyrosine-binding domain in vivo

31 March 2020

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The disabled 1 phosphotyrosine-binding domain binds to the internalization signals of transmembrane glycoproteins and to phospholipids

31 March 2020

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Phosphotyrosine binding domains of Shc and insulin receptor substrate 1 recognize the NPXpY motif in a thermodynamically distinct manner

31 March 2020

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Signaling via Shc family adapter proteins

31 March 2020

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Identification of the Abl- and rasGAP-associated 62 kDa protein as a docking protein, Dok

31 March 2020

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p62(dok): a constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells

31 March 2020

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The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R

31 March 2020

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Recruitment of Dok-R to the EGF receptor through its PTB domain is required for attenuation of Erk MAP kinase activation

31 March 2020

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Multiple ErbB-2/Neu Phosphorylation Sites Mediate Transformation through Distinct Effector Proteins.

31 March 2020

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Insulin receptor-mediated p62dok tyrosine phosphorylation at residues 362 and 398 plays distinct roles for binding GTPase-activating protein and Nck and is essential for inhibiting insulin-stimulated activation of Ras and Akt.

31 March 2020

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Evidence that Llck-mediated phosphorylation of p56dok and p62dok may play a role in CD2 signaling

31 March 2020

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Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells

31 March 2020

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Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein

31 March 2020

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Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2

31 March 2020

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Scrambler, a new neurological mutation of the mouse with abnormalities of neuronal migration

31 March 2020

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Scrambler and yotari disrupt the disabled gene and produce a reeler-like phenotype in mice

31 March 2020

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Aberrant splicing of a mouse disabled homolog, mdab1, in the scrambler mouse

31 March 2020

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Neuronal position in the developing brain is regulated by mouse disabled-1

31 March 2020

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Autosomal recessive hypercholesterolemia caused by mutations in a putative LDL receptor adaptor protein

31 March 2020

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Control of daughter cell fates during asymmetric division: interaction of Numb and Notch

31 March 2020

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Functional analysis of the Numb phosphotyrosine-binding domain using site-directed mutagenesis

31 March 2020

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Structural basis for specificity of Grb2-SH2 revealed by a novel ligand binding mode

31 March 2020

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Solution structure of the SH2 domain of Grb2 complexed with the Shc-derived phosphotyrosine-containing peptide

31 March 2020

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Brief report: a point mutation in the SH2 domain of Bruton's tyrosine kinase in atypical X-linked agammaglobulinemia.

31 March 2020

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Host response to EBV infection in X-linked lymphoproliferative disease results from mutations in an SH2-domain encoding gene

31 March 2020

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Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome

31 March 2020

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Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome

31 March 2020

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SH2 and SH3 domains as targets for anti-proliferative agents

31 March 2020

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Structure-based design of an osteoclast-selective, nonpeptide src homology 2 inhibitor with in vivo antiresorptive activity

31 March 2020

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Mapping specificity determinants for protein-protein association using protein fusions and random peptide libraries

31 March 2020

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A combined experimental and computational strategy to define protein interaction networks for peptide recognition modules

31 March 2020

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SH3-SPOT: an algorithm to predict preferred ligands to different members of the SH3 gene family.

31 March 2020

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SMART, a simple modular architecture research tool: identification of signaling domains

31 March 2020

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Interactions of polyomavirus middle T with the SH2 domains of the pp85 subunit of phosphatidylinositol-3-kinase

31 March 2020

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRM759

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Dimensions Publication ID

3 August 2017

1038206998

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