Energy landscapes as a tool to integrate GPCR structure, dynamics, and function (Q34664404)

3 August 2017

title

Energy landscapes as a tool to integrate GPCR structure, dynamics, and function (English)

1 reference

G protein-coupled receptor

3 August 2017

main subject

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1 reference

2

Brian K Kobilka

1 reference

3 August 2017

Xavier Deupi

1

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publication date

1 October 2010

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3 August 2017

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3 August 2017

volume

25

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3 August 2017

issue

5

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3 August 2017

page(s)

293-303

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Tracking G-protein-coupled receptor activation using genetically encoded infrared probes.

3 August 2017

cites work

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7 July 2018

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7 July 2018

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7 July 2018

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Conserved waters mediate structural and functional activation of family A (rhodopsin-like) G protein-coupled receptors

7 July 2018

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Rhodopsin activation switches in a native membrane environment.

7 July 2018

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Two protonation switches control rhodopsin activation in membranes

7 July 2018

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Crystal structure of opsin in its G-protein-interacting conformation

7 July 2018

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Distinct conformational changes in beta-arrestin report biased agonism at seven-transmembrane receptors.

7 July 2018

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A role for membrane potential in regulating GPCRs?

7 July 2018

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Structure of a beta1-adrenergic G-protein-coupled receptor

7 July 2018

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Dynamic personalities of proteins

7 July 2018

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High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor

7 July 2018

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GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function

7 July 2018

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Crystal structure of the human beta2 adrenergic G-protein-coupled receptor

7 July 2018

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Activation of G protein-coupled receptors

7 July 2018

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Beta-arrestin-biased ligands at seven-transmembrane receptors

7 July 2018

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Conformational complexity of G-protein-coupled receptors

7 July 2018

1 reference

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Structural and functional properties of metarhodopsin III: recent spectroscopic studies on deactivation pathways of rhodopsin

7 July 2018

1 reference

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The role of internal water molecules in the structure and function of the rhodopsin family of G protein-coupled receptors

7 July 2018

1 reference

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G protein-coupled receptors sense fluid shear stress in endothelial cells

7 July 2018

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Local peptide movement in the photoreaction intermediate of rhodopsin

7 July 2018

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Crystallographic analysis of primary visual photochemistry

7 July 2018

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beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor

7 July 2018

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Changes in interhelical hydrogen bonding upon rhodopsin activation

7 July 2018

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Structure of bovine rhodopsin in a trigonal crystal form.

7 July 2018

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Electron crystallography reveals the structure of metarhodopsin I.

7 July 2018

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Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors

7 July 2018

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Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2.

7 July 2018

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Ligand-selective receptor conformations revisited: the promise and the problem

7 July 2018

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Sequence analyses of G-protein-coupled receptors: similarities to rhodopsin

7 July 2018

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Agonist induction and conformational selection during activation of a G-protein-coupled receptor

7 July 2018

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Single-molecule spectroscopy of the beta(2) adrenergic receptor: observation of conformational substates in a membrane protein

7 July 2018

1 reference

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Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6.

7 July 2018

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The effect of pH on beta(2) adrenoceptor function. Evidence for protonation-dependent activation.

7 July 2018

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Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A.

7 July 2018

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Cloning of the gene and cDNA for mammalian beta-adrenergic receptor and homology with rhodopsin

7 July 2018

1 reference

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Functional dynamics of response regulators using NMR relaxation techniques

7 July 2018

1 reference

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Differential transcriptional activation in vitro by NF-kappa B/Rel proteins

21 January 2018

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Functionally different agonists induce distinct conformations in the G protein coupling domain of the beta 2 adrenergic receptor

21 January 2018

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Evolutionary trace of G protein-coupled receptors reveals clusters of residues that determine global and class-specific functions

21 January 2018

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Probing the beta2 adrenoceptor binding site with catechol reveals differences in binding and activation by agonists and partial agonists

21 January 2018

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https://api.crossref.org/works/10.1152%2FPHYSIOL.00002.2010

Exploring the mechanism of agonist efficacy: a relationship between efficacy and agonist dissociation rate at the muscarinic M3 receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00002.2010

Functional role of the "ionic lock"--an interhelical hydrogen-bond network in family A heptahelical receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00002.2010

Coupling ligand structure to specific conformational switches in the beta2-adrenoceptor

21 January 2018

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Elucidating membrane protein function through long-timescale molecular dynamics simulation.

21 January 2018

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Beta-adrenergic receptor subtype-specific signaling in cardiac myocytes from beta(1) and beta(2) adrenoceptor knockout mice

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056154

Visual pigment: G-protein-coupled receptor for light signals

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056154

Using relaxation dispersion NMR spectroscopy to determine structures of excited, invisible protein states

26 October 2018

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12 December 2020

Rhodopsin photoenergetics: lumirhodopsin and the complete energy profile

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12 December 2020

Identification of two serine residues involved in agonist activation of the beta-adrenergic receptor

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12 December 2020

Fluorescent labeling of purified beta 2 adrenergic receptor. Evidence for ligand-specific conformational changes

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12 December 2020

10.1152/PHYSIOL.00002.2010

Identifiers

DOI

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3 August 2017

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3 August 2017

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