A "two-hit" hypothesis for inclusion formation by carboxyl-terminal fragments of TDP-43 protein linked to RNA depletion and impaired microtubule-dependent transport (Q34998181)

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English	A "two-hit" hypothesis for inclusion formation by carboxyl-terminal fragments of TDP-43 protein linked to RNA depletion and impaired microtubule-dependent transport	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

5 August 2017

A "two-hit" hypothesis for inclusion formation by carboxyl-terminal fragments of TDP-43 protein linked to RNA depletion and impaired microtubule-dependent transport (English)

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Europe PubMed Central

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5 August 2017

John Q. Trojanowski

4

object named as

John Q Trojanowski

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Europe PubMed Central

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5 August 2017

author name string

G Scott Pesiridis

1

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Europe PubMed Central

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5 August 2017

Kalyan Tripathy

2

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5 August 2017

Selçuk Tanik

3

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5 August 2017

Virginia M-Y Lee

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5 August 2017

language of work or name

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publication date

24 March 2011

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5 August 2017

Journal of Biological Chemistry

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Europe PubMed Central

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5 August 2017

286

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Europe PubMed Central

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5 August 2017

21

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Europe PubMed Central

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5 August 2017

18845-18855

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Europe PubMed Central

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5 August 2017

describes a project that uses

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3099701/fullTextXML

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Identification of neuronal RNA targets of TDP-43-containing ribonucleoprotein complexes

1 reference

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Phosphorylation regulates proteasomal-mediated degradation and solubility of TAR DNA binding protein-43 C-terminal fragments

1 reference

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Amyotrophic lateral sclerosis-associated proteins TDP-43 and FUS/TLS function in a common biochemical complex to co-regulate HDAC6 mRNA.

1 reference

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8 July 2018

ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS.

1 reference

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1 reference

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Nuclear import impairment causes cytoplasmic trans-activation response DNA-binding protein accumulation and is associated with frontotemporal lobar degeneration

1 reference

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A Drosophila model for TDP-43 proteinopathy

1 reference

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Mutations in TDP-43 link glycine-rich domain functions to amyotrophic lateral sclerosis

1 reference

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Frontotemporal dementia and amyotrophic lateral sclerosis-associated disease protein TDP-43 promotes dendritic branching

1 reference

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Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin

1 reference

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8 July 2018

Truncation and pathogenic mutations facilitate the formation of intracellular aggregates of TDP-43.

1 reference

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TDP-43 is intrinsically aggregation-prone, and amyotrophic lateral sclerosis-linked mutations accelerate aggregation and increase toxicity

1 reference

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Functional mapping of the interaction between TDP-43 and hnRNP A2 in vivo

1 reference

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Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity

1 reference

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Rethinking ALS: the FUS about TDP-43.

1 reference

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mRuby, a bright monomeric red fluorescent protein for labeling of subcellular structures

1 reference

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Structural insights into TDP-43 in nucleic-acid binding and domain interactions

1 reference

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Expression of TDP-43 C-terminal Fragments in Vitro Recapitulates Pathological Features of TDP-43 Proteinopathies

1 reference

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Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies

1 reference

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Structural determinants of the cellular localization and shuttling of TDP-43.

1 reference

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Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.

1 reference

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Enrichment of C-terminal fragments in TAR DNA-binding protein-43 cytoplasmic inclusions in brain but not in spinal cord of frontotemporal lobar degeneration and amyotrophic lateral sclerosis

1 reference

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8 July 2018

Disturbance of nuclear and cytoplasmic TAR DNA-binding protein (TDP-43) induces disease-like redistribution, sequestration, and aggregate formation

1 reference

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A novel CpG-free vertebrate insulator silences the testis-specific SP-10 gene in somatic tissues: role for TDP-43 in insulator function

1 reference

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Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

1 reference

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TDP-43 binds heterogeneous nuclear ribonucleoprotein A/B through its C-terminal tail: an important region for the inhibition of cystic fibrosis transmembrane conductance regulator exon 9 splicing

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1 reference

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1 reference

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1 reference

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Characterization and functional implications of the RNA binding properties of nuclear factor TDP-43, a novel splicing regulator of CFTR exon 9

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1 reference

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Identifiers

10.1074/JBC.M111.231118

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

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