T cell anergy and costimulation (Q35096703)

6 August 2017

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title

T cell anergy and costimulation (English)

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6 August 2017

Leonard J Appleman

1

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6 August 2017

Vassiliki A Boussiotis

series ordinal

2

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6 August 2017

publication date

1 April 2003

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6 August 2017

published in

Immunological Reviews

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6 August 2017

volume

192

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6 August 2017

page(s)

161-180

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Impact of negative selection on the T cell repertoire reactive to a self-peptide: a large fraction of T cell clones escapes clonal deletion

6 August 2017

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Promiscuous gene expression and central T-cell tolerance: more than meets the eye.

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Regulation of T cell apoptosis during the immune response

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Activation-induced cell death: the controversial role of Fas and Fas ligand in immune privilege and tumour counterattack

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Generation of functional thymocytes in the human adult.

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Clonal anergy: persistence in tolerant mice of antigen-binding B lymphocytes incapable of responding to antigen or mitogen

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Induction of tolerance in influenza virus-immune T lymphocyte clones with synthetic peptides of influenza hemagglutinin

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The origin and mechanism of the allograft reaction

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Integration of calcium and cyclic AMP signaling pathways by 14-3-3

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Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo

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Molecular regulation of interleukin-2 expression by CD28 co-stimulation and anergy

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Reversal of in vitro T cell clonal anergy by IL-2 stimulation

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CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines

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7 January 2021

Regulation of lymphokine messenger RNA stability by a surface-mediated T cell activation pathway

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7 January 2021

B-cell surface antigen B7 provides a costimulatory signal that induces T cells to proliferate and secrete interleukin 2.

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7 January 2021

Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation

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7 January 2021

Cloning of B7-2: a CTLA-4 Counter-Receptor That Costimulates Human T Cell Proliferation

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7 January 2021

The B7-CD28 superfamily

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CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones

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7 January 2021

Extrathymic acquisition of tolerance by T lymphocytes

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7 January 2021

CD40 AND CD154 IN CELL-MEDIATED IMMUNITY

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7 January 2021

CD2 sets quantitative thresholds in T cell activation

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7 January 2021

Initiation of signal transduction through the T cell receptor requires the multivalent engagement of peptide/MHC ligands [corrected]

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7 January 2021

MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation

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7 January 2021

Altered T cell receptor ligands trigger a subset of early T cell signals

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7 January 2021

Altered peptide ligand-induced partial T cell activation: molecular mechanisms and role in T cell biology

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7 January 2021

Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells

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7 January 2021

Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+ T cells

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7 January 2021

High levels of interleukin 10 production in vivo are associated with tolerance in SCID patients transplanted with HLA mismatched hematopoietic stem cells.

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7 January 2021

Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression

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7 January 2021

A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

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7 January 2021

Selective anergy of V beta 8+,CD4+ T cells in Staphylococcus enterotoxin B-primed mice

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

Programmed cell death and extrathymic reduction of Vβ8+CD4+ T cells in mice tolerant to Staphylococcus aureus enterotoxin B

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7 January 2021

In vivo induction of anergy in peripheral V beta 8+ T cells by staphylococcal enterotoxin B.

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7 January 2021

Clonal expansion precedes anergy and death of V beta 8+ peripheral T cells responding to staphylococcal enterotoxin B in vivo

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7 January 2021

Absence of B7-dependent responses in CD28-deficient mice

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7 January 2021

Differential T cell costimulatory requirements in CD28-deficient mice

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7 January 2021

CTLA-4 is a second receptor for the B cell activation antigen B7

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7 January 2021

CTLA-4 can function as a negative regulator of T cell activation

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7 January 2021

CTLA-4 ligation blocks CD28-dependent T cell activation

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7 January 2021

Enhancement of antitumor immunity by CTLA-4 blockade

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7 January 2021

Protective immunity to nematode infection is induced by CTLA-4 blockade

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7 January 2021

Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4

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7 January 2021

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

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7 January 2021

IL-10-producing T cells suppress immune responses in anergic tuberculosis patients

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7 January 2021

Interleukin 10-mediated immunosuppression by a variant CD4 T cell epitope of Plasmodium falciparum

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7 January 2021

Cross-reactivity of Borrelia burgdorferi and myelin basic protein-specific T cells is not observed in borrelial encephalomyelitis

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7 January 2021

Cellular Immunity Against Tumor Antigens

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7 January 2021

Alterations in signal transduction molecules in T lymphocytes from tumor-bearing mice

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7 January 2021

CD8(+) tumor-infiltrating T cells are deficient in perforin-mediated cytolytic activity due to defective microtubule-organizing center mobilization and lytic granule exocytosis

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

T cells from late tumor-bearing mice express normal levels of p56lck, p59fyn, ZAP-70, and CD3 zeta despite suppressed cytolytic activity

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

The neglected role of type I interferon in the T-cell response: implications for its clinical use

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https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

Induction of antigen-specific T cell anergy: An early event in the course of tumor progression

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7 January 2021

Mice bearing late-stage tumors have normal functional systemic T cell responses in vitro and in vivo

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7 January 2021

Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients

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7 January 2021

Prevention of chronic rejection in mouse aortic allografts by combined treatment with CTLA4-Ig and anti-CD40 ligand monoclonal antibody

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7 January 2021

CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates

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7 January 2021

Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways

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7 January 2021

p27kip1 functions as an anergy factor inhibiting interleukin 2 transcription and clonal expansion of alloreactive human and mouse helper T lymphocytes

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7 January 2021

Transplantation of anergic histoincompatible bone marrow allografts

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7 January 2021

Identification of the components of the murine T cell antigen receptor complex

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7 January 2021

A new subunit of the human T-cell antigen receptor complex

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7 January 2021

Antigen activation of murine T cells induces tyrosine phosphorylation of a polypeptide associated with the T cell antigen receptor

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7 January 2021

ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain

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7 January 2021

LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation

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7 January 2021

Signal transduction mediated by the T cell antigen receptor: the role of adapter proteins

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7 January 2021

Partial T cell signaling: altered phospho-zeta and lack of zap70 recruitment in APL-induced T cell anergy

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7 January 2021

Zeta phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists

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7 January 2021

Anergic T-lymphocyte clones have altered inositol phosphate, calcium, and tyrosine kinase signaling pathways

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7 January 2021

Induction of the increased Fyn kinase activity in anergic T helper type 1 clones requires calcium and protein synthesis and is sensitive to cyclosporin A

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7 January 2021

Impaired Ca/calcineurin pathway in in vivo anergized CD4 T cells

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7 January 2021

Differential association of protein tyrosine kinases with the T cell receptor is linked to the induction of anergy and its prevention by B7 family-mediated costimulation

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7 January 2021

Human T cell activation. II. A new activation pathway used by a major T cell population via a disulfide-bonded dimer of a 44 kilodalton polypeptide (9.3 antigen)

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7 January 2021

Transmembrane signalling by the T cell antigen receptor. Perturbation of the T3-antigen receptor complex generates inositol phosphates and releases calcium ions from intracellular stores

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7 January 2021

T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif

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7 January 2021

Binding of phosphatidylinositol-3-OH kinase to CD28 is required for T-cell signalling

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7 January 2021

Two distinct intracytoplasmic regions of the T-cell adhesion molecule CD28 participate in phosphatidylinositol 3-kinase association

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7 January 2021

Ligation of CD28 receptor by B7 induces formation of D-3 phosphoinositides in T lymphocytes independently of T cell receptor/CD3 activation

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7 January 2021

CD28 of T lymphocytes associates with phosphatidylinositol 3-kinase

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7 January 2021

p56Lck and p59Fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: implications for T-cell costimulation

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7 January 2021

Src-induced activation of inducible T cell kinase (ITK) requires phosphatidylinositol 3-kinase activity and the Pleckstrin homology domain of inducible T cell kinase

1 reference

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7 January 2021

The role of p21ras in CD28 signal transduction: triggering of CD28 with antibodies, but not the ligand B7-1, activates p21ras

1 reference

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7 January 2021

The cytoplasmic domain of CD28 is both necessary and sufficient for costimulation of interleukin-2 secretion and association with phosphatidylinositol 3'-kinase

1 reference

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7 January 2021

T cell antigen CD28 binds to the GRB-2/SOS complex, regulators of p21ras

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7 January 2021

Direct association of Grb2 with the p85 subunit of phosphatidylinositol 3-kinase

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7 January 2021

The CD28 and CTLA-4 receptors associate with the serine/threonine phosphatase PP2A.

1 reference

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7 January 2021

Evidence that a kinase distinct from protein kinase C and phosphatidylinositol 3-kinase mediates ligation-dependent serine/threonine phosphorylation of the T-lymphocyte co-stimulatory molecule CD28.

1 reference

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7 January 2021

CTLA-4 regulates cell cycle progression during a primary immune response.

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7 January 2021

CD80 (B7-1) binds both CD28 and CTLA-4 with a low affinity and very fast kinetics

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7 January 2021

Structural analysis of CTLA-4 function in vivo

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7 January 2021

Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4

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7 January 2021

Cytotoxic T lymphocyte antigen 4 (CTLA-4) interferes with extracellular signal-regulated kinase (ERK) and Jun NH2-terminal kinase (JNK) activation, but does not affect phosphorylation of T cell receptor zeta and ZAP70.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

CTLA-4 suppresses proximal TCR signaling in resting human CD4(+) T cells by inhibiting ZAP-70 Tyr(319) phosphorylation: a potential role for tyrosine phosphatases

1 reference

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7 January 2021

CTLA-4 ligation suppresses CD28-induced NF-kappaB and AP-1 activity in mouse T cell blasts

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7 January 2021

CTLA4 ligation attenuates AP-1, NFAT and NF-kappaB activity in activated T cells

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

Pathways for phosphoinositide synthesis

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

Increase of the Catalytic Activity of Phospholipase C-γ1 by Tyrosine Phosphorylation

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

CD3 stimulation causes phosphorylation of phospholipase C-gamma 1 on serine and tyrosine residues in a human T-cell line

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

Activation of polyphosphoinositide phospholipase C by guanosine 5'-O-(3-thio)triphosphate and fluoroaluminate in membranes prepared from a human T cell leukemia line, JURKAT

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

Protein kinase C-theta;: signaling from the center of the T-cell synapse

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

Early steps of lymphocyte activation bypassed by synergy between calcium ionophores and phorbol ester

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https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

Phosphatidylinositol hydrolysis in freshly isolated human T lymphocytes

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

CD28 co-stimulates TCR/CD3-induced phosphoinositide turnover in human T lymphocytes

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

The duration of antigenic stimulation determines the fate of naive and effector T cells.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

Selective activation of the calcium signaling pathway by altered peptide ligands

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

Transcriptional mechanisms underlying lymphocyte tolerance.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

Effects of cyclosporin A, rapamycin, and FK520 on peripheral T-cell deletion and anergy

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

T-cell clonal anergy.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

Expression of NFAT-family proteins in normal human T cells

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

An enhanced immune response in mice lacking the transcription factor NFAT1.

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https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

Hyperproliferation and dysregulation of IL-4 expression in NF-ATp-deficient mice

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https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

The phosphoinositide 3-kinase pathway

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https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

A phosphatidylinositol 3-kinase is induced during soybean nodule organogenesis and is associated with membrane proliferation

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https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase

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https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85

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7 January 2021

A novel 55-kDa regulatory subunit for phosphatidylinositol 3-kinase structurally similar to p55PIK Is generated by alternative splicing of the p85alpha gene

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7 January 2021

The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase

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7 January 2021

Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

Activation of phosphatidylinositol 3-kinase in cells expressing abl oncogene variants

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

Inhibition of CD28-mediated T cell costimulation by the phosphoinositide 3-kinase inhibitor wortmannin

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

Phosphoinositide 3-kinase regulation of T cell receptor-mediated interleukin-2 gene expression in normal T cells

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

CD28 costimulation mediates down-regulation of p27kip1 and cell cycle progression by activation of the PI3K/PKB signaling pathway in primary human T cells

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

Selective CD28pYMNM mutations implicate phosphatidylinositol 3-kinase in CD86-CD28-mediated costimulation

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

Tyrosine phosphorylation of the CD3-epsilon subunit of the T cell antigen receptor mediates enhanced association with phosphatidylinositol 3-kinase in Jurkat T cells

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

Essential role for protein kinase B (PKB) in insulin-induced glycogen synthase kinase 3 inactivation. Characterization of dominant-negative mutant of PKB.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

A molecular mechanism for the effect of lithium on development

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

PI 3-K and T-cell activation: limitations of T-leukemic cell lines as signaling models.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

p110δ, a novel phosphoinositide 3-kinase in leukocytes

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

Critical requirement for the membrane-proximal cytosolic tyrosine residue for CD28-mediated costimulation in vivo

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

A point mutation in CD28 distinguishes proliferative signals from survival signals

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

RapV12 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat-1 fibroblasts

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

CD28 and the tyrosine kinase lck stimulate mitogen-activated protein kinase activity in T cells via inhibition of the small G protein Rap1.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

Maintenance of human T cell anergy: blocking of IL-2 gene transcription by activated Rap1

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

Rap1 functions as a key regulator of T-cell and antigen-presenting cell interactions and modulates T-cell responses

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

Costimulation through CD28 suppresses T cell receptor-dependent activation of the Ras-like small GTPase Rap1 in human T lymphocytes

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

Extracellular signal-regulated activation of Rap1 fails to interfere in Ras effector signalling

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

Stimulation of p21 ras upon T-cell activation

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

RasGRP, a Ras guanyl nucleotide- releasing protein with calcium- and diacylglycerol-binding motifs

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

CalDAG-GEFIII activation of Ras, R-ras, and Rap1.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

GRB2 and phospholipase C-gamma 1 associate with a 36- to 38-kilodalton phosphotyrosine protein after T-cell receptor stimulation

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

Activation of Raf as a result of recruitment to the plasma membrane

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

Involvement of p21ras in activation of extracellular signal-regulated kinase 2.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

MAP kinase kinase kinase, MAP kinase kinase and MAP kinase

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

Blocked Signal Transduction to the ERK and JNK Protein Kinases in Anergic CD4+ T Cells

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

Blocked Ras activation in anergic CD4+ T cells

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

Identification of Rap1 as a target for the Crk SH3 domain-binding guanine nucleotide-releasing factor C3G

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

A family of cAMP-binding proteins that directly activate Rap1

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

Role of the CDC25 homology domain of phospholipase Cepsilon in amplification of Rap1-dependent signaling

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

CD98 induces LFA-1-mediated cell adhesion in lymphoid cells via activation of Rap1.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

Cyclic AMP-mediated inhibition of cell growth requires the small G protein Rap1.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

The role of cell division in the induction of clonal anergy

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

CD28 costimulation mediates T cell expansion via IL-2-independent and IL-2-dependent regulation of cell cycle progression

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

CDK inhibitors: positive and negative regulators of G1-phase progression

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

Direct control of the Forkhead transcription factor AFX by protein kinase B

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

Role of the F-box protein Skp2 in lymphomagenesis

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

CD28 affects the earliest signaling events generated by TCR engagement

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

Requirements for peptide-induced T cell receptor downregulation on naive CD8+ T cells

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

T lymphocyte costimulation mediated by reorganization of membrane microdomains

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

Three-dimensional segregation of supramolecular activation clusters in T cells

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00009.X

7 January 2021

10.1034/J.1600-065X.2003.00009.X

Identifiers

DOI

1 reference

release_hqirzarhlbdbjey2xafpaz7niy

6 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/hqirzarhlbdbjey2xafpaz7niy

24 November 2022

mapped directly with Wikidata item

1 reference