Casein kinase II induced polymerization of soluble TDP-43 into filaments is inhibited by heat shock proteins (Q35111101)

6 August 2017

title

Casein kinase II induced polymerization of soluble TDP-43 into filaments is inhibited by heat shock proteins (English)

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6 August 2017

10

Leonard Petrucelli

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6 August 2017

Yari Carlomagno

1

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6 August 2017

Yongjie Zhang

2

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6 August 2017

Mary Davis

3

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6 August 2017

Wen-Lang Lin

4

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6 August 2017

Casey Cook

5

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6 August 2017

Judy Dunmore

6

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6 August 2017

William Tay

7

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6 August 2017

Kyle Menkosky

8

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6 August 2017

Xiangkun Cao

9

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6 August 2017

Michael Deture

11

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6 August 2017

language of work or name

English

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publication date

4 March 2014

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6 August 2017

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6 August 2017

volume

9

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6 August 2017

issue

3

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6 August 2017

page(s)

e90452

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Creative Commons Attribution 4.0 International

6 August 2017

copyright license

start time

4 March 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

TDP-43 Phosphorylation by casein kinase Iε promotes oligomerization and enhances toxicity in vivo.

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Prion-like nuclear aggregation of TDP-43 during heat shock is regulated by HSP40/70 chaperones

9 July 2018

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Prion-like properties of pathological TDP-43 aggregates from diseased brains

9 July 2018

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TARDBP mutation analysis in TDP-43 proteinopathies and deciphering the toxicity of mutant TDP-43

9 July 2018

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Targeted depletion of TDP-43 expression in the spinal cord motor neurons leads to the development of amyotrophic lateral sclerosis-like phenotypes in mice

9 July 2018

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Cdc37/Hsp90 protein complex disruption triggers an autophagic clearance cascade for TDP-43 protein

9 July 2018

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Microglial activation and TDP-43 pathology correlate with executive dysfunction in amyotrophic lateral sclerosis

9 July 2018

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Heat shock protein 70 prevents both tau aggregation and the inhibitory effects of preexisting tau aggregates on fast axonal transport.

9 July 2018

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Pseudohyperphosphorylation has differential effects on polymerization and function of tau isoforms

9 July 2018

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Apigenin inhibits proliferation and induces apoptosis in human multiple myeloma cells through targeting the trinity of CK2, Cdc37 and Hsp90

9 July 2018

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Hyperphosphorylation as a defense mechanism to reduce TDP-43 aggregation

9 July 2018

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An ALS-associated mutation affecting TDP-43 enhances protein aggregation, fibril formation and neurotoxicity

9 July 2018

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A "two-hit" hypothesis for inclusion formation by carboxyl-terminal fragments of TDP-43 protein linked to RNA depletion and impaired microtubule-dependent transport

9 July 2018

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A seeding reaction recapitulates intracellular formation of Sarkosyl-insoluble transactivation response element (TAR) DNA-binding protein-43 inclusions

9 July 2018

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β-amyloid triggers ALS-associated TDP-43 pathology in AD models

9 July 2018

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Phosphorylation promotes neurotoxicity in a Caenorhabditis elegans model of TDP-43 proteinopathy

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3942448

Regulation of TDP-43 aggregation by phosphorylation and p62/SQSTM1.

9 July 2018

1 reference

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Tar DNA Binding Protein-43 (TDP-43) Associates with Stress Granules: Analysis of Cultured Cells and Pathological Brain Tissue

9 July 2018

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Phosphorylation regulates proteasomal-mediated degradation and solubility of TAR DNA binding protein-43 C-terminal fragments

9 July 2018

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Interaction with polyglutamine aggregates reveals a Q/N-rich domain in TDP-43.

9 July 2018

1 reference

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Hsc70 rapidly engages tau after microtubule destabilization

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3942448

Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3942448

Gain and loss of function of ALS-related mutations of TARDBP (TDP-43) cause motor deficits in vivo

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3942448

TDP-43 is intrinsically aggregation-prone, and amyotrophic lateral sclerosis-linked mutations accelerate aggregation and increase toxicity

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3942448

Amyotrophic lateral sclerosis, frontotemporal dementia and beyond: the TDP-43 diseases

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3942448

Phosphorylated and ubiquitinated TDP-43 pathological inclusions in ALS and FTLD-U are recapitulated in SH-SY5Y cells

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3942448

Aging analysis reveals slowed tau turnover and enhanced stress response in a mouse model of tauopathy

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3942448

Fine structural analysis of the neuronal inclusions of frontotemporal lobar degeneration with TDP-43 proteinopathy.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3942448

Novel mutations in TARDBP (TDP-43) in patients with familial amyotrophic lateral sclerosis

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3942448

Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3942448

Two motifs within the tau microtubule-binding domain mediate its association with the hsc70 molecular chaperone.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3942448

TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis

9 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3942448

TDP-43 A315T mutation in familial motor neuron disease

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3942448

Progranulin mediates caspase-dependent cleavage of TAR DNA binding protein-43.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3942448

Molecular chaperone-mediated tau protein metabolism counteracts the formation of granular tau oligomers in human brain

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3942448

The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3942448

Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3942448

TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3942448

Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3942448

TDP-43 binds heterogeneous nuclear ribonucleoprotein A/B through its C-terminal tail: an important region for the inhibition of cystic fibrosis transmembrane conductance regulator exon 9 splicing

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3942448

Chaperones increase association of tau protein with microtubules

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3942448

Higher order arrangement of the eukaryotic nuclear bodies

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3942448

The assembly and intermolecular properties of the hsp70-Hop-hsp90 molecular chaperone complex

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3942448

Casein kinase II alteration precedes tau accumulation in tangle formation

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3942448

The 90-kDa heat shock protein, HSP90, binds and protects casein kinase II from self-aggregation and enhances its kinase activity.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3942448

Molecular analysis and biochemical classification of TDP-43 proteinopathy

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3942448

Ultrastructural localization of TDP-43 in filamentous neuronal inclusions in various neurodegenerative diseases

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3942448

Concurrence of TDP-43, tau and alpha-synuclein pathology in brains of Alzheimer's disease and dementia with Lewy bodies

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3942448

Absence of heterogeneous nuclear ribonucleoproteins and survival motor neuron protein in TDP-43 positive inclusions in frontotemporal lobar degeneration

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3942448

Human, Drosophila, and C.elegans TDP43: nucleic acid binding properties and splicing regulatory function

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3942448

Neurodegenerative disease: amyloid pores from pathogenic mutations

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3942448

Aberrant casein kinase II in Alzheimer's disease

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3942448

10.1371/JOURNAL.PONE.0090452

27 September 2018

Identifiers

DOI

1 reference

6 August 2017

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1 reference

6 August 2017

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