The 'ORC cycle': a novel pathway for regulating eukaryotic DNA replication (Q35152182)

6 August 2017

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title

The 'ORC cycle': a novel pathway for regulating eukaryotic DNA replication (English)

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6 August 2017

Melvin L DePamphilis

1

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6 August 2017

language of work or name

English

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publication date

1 May 2003

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6 August 2017

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6 August 2017

volume

310

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6 August 2017

page(s)

1-15

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Cell cycle modulation of protein-DNA interactions at a human replication origin

6 August 2017

cites work

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7 January 2021

Start sites of bidirectional DNA synthesis at the human lamin B2 origin

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7 January 2021

Localization of proteins bound to a replication origin of human DNA along the cell cycle

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7 January 2021

The Chinese hamster dihydrofolate reductase replication origin beta is active at multiple ectopic chromosomal locations and requires specific DNA sequence elements for activity

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7 January 2021

E2F mediates developmental and cell cycle regulation of ORC1 in Drosophila

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7 January 2021

Drosophila ORC specifically binds to ACE3, an origin of DNA replication control element

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7 January 2021

Role for a Drosophila Myb-containing protein complex in site-specific DNA replication.

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7 January 2021

The origin recognition complex: from simple origins to complex functions

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7 January 2021

DNA replication in eukaryotic cells

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7 January 2021

Origin recognition complex binding to a metazoan replication origin

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7 January 2021

Initiation of eukaryotic DNA replication: conservative or liberal?

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7 January 2021

DNA replication control through interaction of E2F-RB and the origin recognition complex

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7 January 2021

Identification of a novel 81-kDa component of the Xenopus origin recognition complex

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Functional analysis of mutant and wild-type Drosophila origin recognition complex

1 reference

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7 January 2021

The Xenopus Cdc6 protein is essential for the initiation of a single round of DNA replication in cell-free extracts

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7 January 2021

Multiple mechanisms regulate subcellular localization of human CDC6.

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7 January 2021

Eukaryotic DNA replication: anatomy of an origin

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7 January 2021

Review: nuclear structure and DNA replication

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7 January 2021

Identification and characterization of the human ORC6 homolog

1 reference

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7 January 2021

Architecture of the human origin recognition complex

1 reference

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7 January 2021

Two steps in the assembly of complexes at yeast replication origins in vivo

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7 January 2021

Remodeling sperm chromatin in Xenopus laevis egg extracts: the role of core histone phosphorylation and linker histone B4 in chromatin assembly

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7 January 2021

The spatial position and replication timing of chromosomal domains are both established in early G1 phase

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https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Mcm2, but not RPA, is a component of the mammalian early G1-phase prereplication complex

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Dynamics of association of origins of DNA replication with the nuclear matrix during the cell cycle

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https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

The Cdc4/34/53 pathway targets Cdc6p for proteolysis in budding yeast

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

MCM2-7 complexes bind chromatin in a distributed pattern surrounding the origin recognition complex in Xenopus egg extracts.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Cyclin A-dependent kinase activity affects chromatin binding of ORC, Cdc6, and MCM in egg extracts of Xenopus laevis

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Cell cycle dependent topological changes of chromosomal replication origins in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Nuclear organization of DNA replication initiation proteins in mammalian cells

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https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Site-specific initiation of DNA replication in Xenopus egg extract requires nuclear structure

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Reconstitution of licensed replication origins on Xenopus sperm nuclei using purified proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

A new ticket for entry into budding vesicles-ubiquitin

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Identification of a preinitiation step in DNA replication that is independent of origin recognition complex and cdc6, but dependent on cdk2

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Transition in specification of embryonic metazoan DNA replication origins

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Site-specific and temporally controlled initiation of DNA replication in a human cell-free system

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

The origin recognition complex marks a replication origin in the human TOP1 gene promoter

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Multiple orientation-dependent, synergistically interacting, similar domains in the ribosomal DNA replication origin of the fission yeast, Schizosaccharomyces pombe

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

ATP bound to the origin recognition complex is important for preRC formation

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Coordinate binding of ATP and origin DNA regulates the ATPase activity of the origin recognition complex

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Site-specific DNA binding of the Schizosaccharomyces pombe origin recognition complex is determined by the Orc4 subunit

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Site-specific ORC binding, pre-replication complex assembly and DNA synthesis at Schizosaccharomyces pombe replication origins

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

The human origin recognition complex protein 1 dissociates from chromatin during S phase in HeLa cells

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

G1-phase and B-type cyclins exclude the DNA-replication factor Mcm4 from the nucleus

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Identification of a binding region for human origin recognition complex proteins 1 and 2 that coincides with an origin of DNA replication

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Cyclin-mediated export of human Orc1.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Regulation of origin recognition complex conformation and ATPase activity: differential effects of single-stranded and double-stranded DNA binding

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

The Schizosaccharomyces pombe origin recognition complex interacts with multiple AT-rich regions of the replication origin DNA by means of the AT-hook domains of the spOrc4 protein

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

E2F3 activity is regulated during the cell cycle and is required for the induction of S phase.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Mammalian Orc1 protein is selectively released from chromatin and ubiquitinated during the S-to-M transition in the cell division cycle

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

The replication timing program of the Chinese hamster beta-globin locus is established coincident with its repositioning near peripheral heterochromatin in early G1 phase

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Persistent initiation of DNA replication and chromatin-bound MCM proteins during the cell cycle in cdc6 mutants

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Aberrant replication timing induces defective chromosome condensation in Drosophila ORC2 mutants

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

DNA replication in quiescent cell nuclei: regulation by the nuclear envelope and chromatin structure

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Functionally distinct, sequence-specific replicator and origin elements are required for Drosophila chorion gene amplification

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

The roles of the MCM, ORC, and Cdc6 proteins in determining the replication competence of chromatin in quiescent cells

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Selective instability of Orc1 protein accounts for the absence of functional origin recognition complexes during the M-G(1) transition in mammals

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Clb/Cdc28 kinases promote nuclear export of the replication initiator proteins Mcm2-7.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Cyclin-dependent kinases prevent DNA re-replication through multiple mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

The comparative effects of short-term DNA inhibition on replicon synthesis in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

The ORC1 cycle in human cells: I. cell cycle-regulated oscillation of human ORC1.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Expression of the HsOrc1 gene, a human ORC1 homolog, is regulated by cell proliferation via the E2F transcription factor

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Regulation of cell growth-dependent expression of mammalian CDC6 gene by the cell cycle transcription factor E2F.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Stability, chromatin association and functional activity of mammalian pre-replication complex proteins during the cell cycle

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Association of the origin recognition complex with heterochromatin and HP1 in higher eukaryotes

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Nuclear localization of Schizosaccharomyces pombe Mcm2/Cdc19p requires MCM complex assembly

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Unphosphorylatable mutants of Cdc6 disrupt its nuclear export but still support DNA replication once per cell cycle

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Cell cycle- and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Nucleoplasmin remodels sperm chromatin in Xenopus egg extracts

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Orc6 involved in DNA replication, chromosome segregation, and cytokinesis.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Replication dynamics of the yeast genome.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Human minichromosome maintenance proteins and human origin recognition complex 2 protein on chromatin

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

The Xenopus origin recognition complex is essential for DNA replication and MCM binding to chromatin

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Interaction of Xenopus Cdc2 x cyclin A1 with the origin recognition complex

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Interaction between the origin recognition complex and the replication licensing system in Xenopus.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Initiation complex assembly at budding yeast replication origins begins with the recognition of a bipartite sequence by limiting amounts of the initiator, ORC

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Functional domains involved in the interaction between Orc1 and transcriptional repressor AlF-C that bind to an origin/promoter of the rat aldolase B gene

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Activation of dormant origins of DNA replication in budding yeast

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Specification of regions of DNA replication initiation during embryogenesis in the 65-kilobase DNApolalpha-dE2F locus of Drosophila melanogaster

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Heterogeneity in nuclear transport does not affect the timing of DNA synthesis in quiescent mammalian nuclei induced to replicate in Xenopus egg extracts

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Cell cycle-dependent regulation of the association between origin recognition proteins and somatic cell chromatin

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Association of human origin recognition complex 1 with chromatin DNA and nuclease-resistant nuclear structures

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Subsets of human origin recognition complex (ORC) subunits are expressed in non-proliferating cells and associate with non-ORC proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

The Orc4p and Orc5p subunits of the Xenopus and human origin recognition complex are related to Orc1p and Cdc6p

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Control of DNA rereplication via Cdc2 phosphorylation sites in the origin recognition complex

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Assembly of the human origin recognition complex

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Regulated chromosomal DNA replication in the absence of a nucleus

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Binding of cyclin-dependent kinases to ORC and Cdc6p regulates the chromosome replication cycle

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Intracellular targeting of proteins by sumoylation

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Inhibition of eukaryotic DNA replication by geminin binding to Cdt1

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Xenopus Mcm10 binds to origins of DNA replication after Mcm2-7 and stimulates origin binding of Cdc45.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

A distinct G1 step required to specify the Chinese hamster DHFR replication origin

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

The Replication Origin Decision Point Is a Mitogen-Independent, 2-Aminopurine-Sensitive, G1-Phase Event That Precedes Restriction Point Control

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Stable association of mitotic cyclin B/Cdc2 to replication origins prevents endoreduplication

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Genome-wide distribution of ORC and MCM proteins in S. cerevisiae: high-resolution mapping of replication origins.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Analysis of mammalian origin specification in ORC-depleted Xenopus egg extracts

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

The units of DNA replication in the mammalian chromosomes: evidence for a large size of replication units

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2803%2900546-8

7 January 2021

Mammalian nuclei become licensed for DNA replication during late telophase

1 reference

2 April 2022

https://opencitations.net/index/coci/api/v1/citations/10.1242/JCS.115.1.51

Identifiers

DOI

10.1016/S0378-1119(03)00546-8

1 reference

6 August 2017

1 reference