Presenilin-like GxGD membrane proteases have dual roles as proteolytic enzymes and ion channels (Q35172983)

25609250

6 August 2017

title

Presenilin-like GxGD membrane proteases have dual roles as proteolytic enzymes and ion channels (English)

1 reference

6 August 2017

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1

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31 May 2020

Barbara E. Ehrlich

series ordinal

4

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31 May 2020

author name string

Jian Hu

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25609250%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

Ya Ha

series ordinal

3

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31 May 2020

language of work or name

English

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publication date

21 January 2015

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25609250

Journal of Biological Chemistry

6 August 2017

published in

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31 May 2020

volume

290

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31 May 2020

issue

10

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31 May 2020

page(s)

6419-6427

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Three-dimensional structure of human γ-secretase

31 May 2020

cites work

1 reference

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Presenilins and calcium signaling-systems biology to the rescue

13 July 2018

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Structure of a presenilin family intramembrane aspartate protease

13 July 2018

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Calcium leak through ryanodine receptors leads to atrial fibrillation in 3 mouse models of catecholaminergic polymorphic ventricular tachycardia.

13 July 2018

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Repression of transcription of presenilin-1 inhibits γ-secretase independent ER Ca²⁺ leak that is impaired by FAD mutations

13 July 2018

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Lack of evidence for presenilins as endoplasmic reticulum Ca2+ leak channels

13 July 2018

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The crystal structure of GXGD membrane protease FlaK

13 July 2018

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Endoplasmic reticulum Ca(2+) handling in excitable cells in health and disease

13 July 2018

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Presenilins function in ER calcium leak and Alzheimer's disease pathogenesis

13 July 2018

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Compounding artefacts with uncertainty, and an amyloid cascade hypothesis that is 'too big to fail'.

13 July 2018

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Mutagenesis mapping of the presenilin 1 calcium leak conductance pore

13 July 2018

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Altered ryanodine receptor expression in mild cognitive impairment and Alzheimer's disease

13 July 2018

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Identification of an archaeal presenilin-like intramembrane protease

13 July 2018

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Gain-of-function enhancement of IP3 receptor modal gating by familial Alzheimer's disease-linked presenilin mutants in human cells and mouse neurons

13 July 2018

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ER calcium and Alzheimer's disease: in a state of flux

13 July 2018

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The amyloid hypothesis for Alzheimer's disease: a critical reappraisal

13 July 2018

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Presenilin-2 dampens intracellular Ca2+ stores by increasing Ca2+ leakage and reducing Ca2+ uptake

13 July 2018

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Mechanism of Ca2+ disruption in Alzheimer's disease by presenilin regulation of InsP3 receptor channel gating.

13 July 2018

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Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1

13 July 2018

1 reference

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Structure of the catalytic pore of gamma-secretase probed by the accessibility of substituted cysteines.

13 July 2018

1 reference

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Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations

13 July 2018

1 reference

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The presenilin-2 loop peptide perturbs intracellular Ca2+ homeostasis and accelerates apoptosis

13 July 2018

1 reference

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Organic cation permeation through the channel formed by polycystin-2.

13 July 2018

1 reference

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Reduction of Ca2+ stores and capacitative Ca2+ entry is associated with the familial Alzheimer's disease presenilin-2 T122R mutation and anticipates the onset of dementia.

13 July 2018

1 reference

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Calcium dysregulation, IP3 signaling, and Alzheimer's disease

13 July 2018

1 reference

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Functional implications of the presenilin dimerization: reconstitution of gamma-secretase activity by assembly of a catalytic site at the dimer interface of two catalytically inactive presenilins

13 July 2018

1 reference

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Mg2+ Homeostasis: The Mg2+nificent TRPM Chanzymes

13 July 2018

1 reference

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Dimerization of presenilin-1 in vivo: suggestion of novel regulatory mechanisms leading to higher order complexes

13 July 2018

1 reference

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Calsenilin reverses presenilin-mediated enhancement of calcium signaling

13 July 2018

1 reference

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Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

13 July 2018

1 reference

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Presenilin-2 mutations modulate amplitude and kinetics of inositol 1, 4,5-trisphosphate-mediated calcium signals

13 July 2018

1 reference

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Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

13 July 2018

1 reference

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Alzheimer's presenilin-1 mutation potentiates inositol 1,4,5-trisphosphate-mediated calcium signaling in Xenopus oocytes

13 July 2018

1 reference

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Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

13 July 2018

1 reference

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Regulators of calcium homeostasis identified by inference of kinetic model parameters from live single cells perturbed by siRNA.

13 July 2018

1 reference

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Structural biology: Membrane enzyme cuts a fine figure

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4358277

Enhanced ryanodine-mediated calcium release in mutant PS1-expressing Alzheimer's mouse models

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4358277

Enhanced ryanodine receptor recruitment contributes to Ca2+ disruptions in young, adult, and aged Alzheimer's disease mice.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4358277

Detection of presenilin-1 homodimer formation in intact cells using fluorescent lifetime imaging microscopy.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4358277

Homodimerization of presenilin N-terminal fragments is affected by mutations linked to Alzheimer's disease

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4358277

27 September 2018

Identifiers

DOI

10.1074/JBC.M114.629584

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25609250%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

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31 May 2020

25609250

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