Clonal Deletion Prunes but Does Not Eliminate Self-Specific αβ CD8(+) T Lymphocytes (Q35683291)

25992863

9 August 2017

title

Clonal Deletion Prunes but Does Not Eliminate Self-Specific αβ CD8(+) T Lymphocytes (English)

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9 August 2017

2

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12 June 2020

Brian A Kidd

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12 June 2020

Sabina Müller

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12 June 2020

Michael E Birnbaum

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12 June 2020

Evan W Newell

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12 June 2020

Salvatore Valitutti

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Stephen R Quake

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12 June 2020

author name string

Wong Yu

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12 June 2020

Peter J R Ebert

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12 June 2020

Peder J Lund

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Jeremy Juang

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Keishi Adachi

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Tiffany Tse

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Darrell M Wilson

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Gijsbert M Grotenbreg

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Mark M Davis

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12 June 2020

language of work or name

English

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publication date

1 May 2015

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9 August 2017

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12 June 2020

volume

42

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12 June 2020

issue

5

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12 June 2020

page(s)

929-941

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The TCR's sensitivity to self peptide-MHC dictates the ability of naive CD8(+) T cells to respond to foreign antigens

12 June 2020

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12 July 2018

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12 July 2018

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Circulating preproinsulin signal peptide-specific CD8 T cells restricted by the susceptibility molecule HLA-A24 are expanded at onset of type 1 diabetes and kill β-cells

12 July 2018

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Personal omics profiling reveals dynamic molecular and medical phenotypes

12 July 2018

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Cytometry by time-of-flight shows combinatorial cytokine expression and virus-specific cell niches within a continuum of CD8+ T cell phenotypes

12 July 2018

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Quantitative impact of thymic selection on Foxp3+ and Foxp3- subsets of self-peptide/MHC class II-specific CD4+ T cells

12 July 2018

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12 July 2018

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Simultaneous detection of circulating autoreactive CD8+ T-cells specific for different islet cell-associated epitopes using combinatorial MHC multimers.

12 July 2018

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On the composition of the preimmune repertoire of T cells specific for Peptide-major histocompatibility complex ligands

12 July 2018

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Regulatory T cells exert checks and balances on self tolerance and autoimmunity

12 July 2018

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Loss of parity between IL-2 and IL-21 in the NOD Idd3 locus

12 July 2018

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Simultaneous detection of many T-cell specificities using combinatorial tetramer staining.

12 July 2018

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Intraclonal competition limits the fate determination of regulatory T cells in the thymus

12 July 2018

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Association of reactive oxygen species levels and radioresistance in cancer stem cells

12 July 2018

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Complete but curtailed T-cell response to very low-affinity antigen

12 July 2018

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Hepatitis C virus immune escape via exploitation of a hole in the T cell repertoire

12 July 2018

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Clonal deletion of thymocytes can occur in the cortex with no involvement of the medulla

12 July 2018

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CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope

12 July 2018

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Deletional tolerance mediated by extrathymic Aire-expressing cells

12 July 2018

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Naive precursor frequencies and MHC binding rather than the degree of epitope diversity shape CD8+ T cell immunodominance

12 July 2018

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Thymic selection determines gammadelta T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon gamma

12 July 2018

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Endogenous naive CD8+ T cell precursor frequency regulates primary and memory responses to infection

12 July 2018

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Naive CD4(+) T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude.

12 July 2018

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12 July 2018

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12 July 2018

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T cells with low avidity for a tissue-restricted antigen routinely evade central and peripheral tolerance and cause autoimmunity

12 July 2018

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12 July 2018

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Functional avidity directs T-cell fate in autoreactive CD4+ T cells

12 July 2018

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Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice

12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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The HLA-A*0201-restricted H-Y antigen contains a posttranslationally modified cysteine that significantly affects T cell recognition

12 July 2018

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12 July 2018

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CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL.

12 July 2018

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Somatic generation of antibody diversity

12 July 2018

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Positive and negative selection of an antigen receptor on T cells in transgenic mice.

12 July 2018

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Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

12 July 2018

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In transgenic mice the introduced functional T cell receptor beta gene prevents expression of endogenous beta genes

12 July 2018

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Unresponsiveness to a foreign antigen can be caused by self-tolerance

12 July 2018

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12 July 2018

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12 July 2018

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Phenotypic differences between alpha beta versus beta T-cell receptor transgenic mice undergoing negative selection

12 July 2018

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12 July 2018

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Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice

12 July 2018

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Superantigens: mechanism of T-cell stimulation and role in immune responses

12 July 2018

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Immunodominance of HLA-A2-restricted hepatitis C virus-specific CD8+ T cell responses is linked to naive-precursor frequency

12 July 2018

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25 September 2018

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25 September 2018

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25 September 2018

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25 September 2018

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25 September 2018

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25 September 2018

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Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections

25 September 2018

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High frequencies of naive Melan-A/MART-1-specific CD8(+) T cells in a large proportion of human histocompatibility leukocyte antigen (HLA)-A2 individuals

25 September 2018

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25 September 2018

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23 October 2018

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12 December 2020

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Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope

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12 December 2020

CD8+ T-cell responses identify beta-cell autoimmunity in human type 1 diabetes

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The frequency and immunodominance of islet-specific CD8+ T-cell responses change after type 1 diabetes diagnosis and treatment

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12 December 2020

Flow cytometric analysis of the Vbeta repertoire in healthy controls

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12 December 2020

Impact of negative selection on the T cell repertoire reactive to a self-peptide: a large fraction of T cell clones escapes clonal deletion

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12 December 2020

Analysis of endogenous peptides bound by soluble MHC class I molecules: a novel approach for identifying tumor-specific antigens

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DOI

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25992863

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