Back to central tolerance (Q35772859)

10 August 2017

title

Back to central tolerance (English)

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10 August 2017

2

Christophe Benoist

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10 August 2017

Diane Mathis

1

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10 August 2017

language of work or name

English

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publication date

1 May 2004

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10 August 2017

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10 August 2017

volume

20

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10 August 2017

issue

5

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10 August 2017

page(s)

509-516

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Understanding autoimmune diabetes: insights from mouse models.

10 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

Lymphostromal interactions in thymic development and function

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

Projection of an immunological self shadow within the thymus by the aire protein

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

Origin of regulatory T cells with known specificity for antigen

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

Deficient activation and resistance to activation-induced apoptosis of CD8+ T cells is associated with defective peripheral tolerance in nonobese diabetic mice.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

Type 1 diabetes: new perspectives on disease pathogenesis and treatment

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

Tolerance to islet autoantigens in type 1 diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

Association between alphabetaTCR+CD4-CD8- T-cell deficiency and IDDM in NOD/Lt mice

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

CTLA-4-/- mice display T cell-apoptosis resistance resembling that ascribed to autoimmune-prone non-obese diabetic (NOD) mice

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

Diabetes protection and restoration of thymocyte apoptosis in NOD Idd6 congenic strains

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

Thymic medullary epithelial cell differentiation, thymocyte emigration, and the control of autoimmunity require lympho-epithelial cross talk via LTbetaR.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

Dynamics of thymocyte-stromal cell interactions visualized by two-photon microscopy.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

Insulin expression levels in the thymus modulate insulin-specific autoreactive T-cell tolerance: the mechanism by which the IDDM2 locus may predispose to diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

Lymphotoxin pathway directs thymic Aire expression

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

Apoptosis resistance of nonobese diabetic peripheral lymphocytes linked to the Idd5 diabetes susceptibility region

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

Defect in activation-induced cell death in non-obese diabetic (NOD) T lymphocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

Proinsulin 2 knockout NOD mice: a model for genetic variation of insulin gene expression in type 1 diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

Genetic analysis of immune dysfunction in non-obese diabetic (NOD) mice: Mapping of a susceptibility locus close to theBcl-2 gene correlates with increased resistance of NOD T cells to apoptosis induction

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

Thymic generation and regeneration

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

Early quantitative and functional deficiency of NK1+-like thymocytes in the NOD mouse

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

Medullary epithelial cells of the human thymus express a highly diverse selection of tissue-specific genes colocalized in chromosomal clusters

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

A defect in tryptophan catabolism impairs tolerance in nonobese diabetic mice

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

APECED mutations in the autoimmune regulator (AIRE) gene

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

The repertoire of T cells shaped by a single MHC/peptide ligand.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

T-cell tolerance toward a transgenic beta-cell antigen and transcription of endogenous pancreatic genes in thymus

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

Autoreactivity of T cells from nonobese diabetic mice: an I-Ag7-dependent reaction

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

Difference in antigen presentation pathways between cortical and medullary thymic epithelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

CLIP-derived self peptides bound to MHC class II molecules of medullary thymic epithelial cells differ from those of cortical thymic epithelial cells in their diversity, length, and C-terminal processing

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

Negative selection in the thymus includes semimature T cells

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

Several different cell surface molecules control negative selection of medullary thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

A defect in central tolerance in NOD mice

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

Differing roles for B7 and intercellular adhesion molecule-1 in negative selection of thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

CD4 T cell tolerance to human C-reactive protein, an inducible serum protein, is mediated by medullary thymic epithelium

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

Defective CD8+ T Cell Peripheral Tolerance in Nonobese Diabetic Mice

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

The autoimmune regulator (AIRE) is a DNA-binding protein

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

CCR7 directs the migration of thymocytes into the thymic medulla

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

Promiscuous gene expression and central T-cell tolerance: more than meets the eye.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

Resistance of T-cells to apoptosis in autoimmune diabetic (NOD) mice is increased early in life and is associated with dysregulated expression of Bcl-x.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

Non-obese diabetic (NOD) mice display enhanced immune responses and prolonged survival of lymphoid cells

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

Failure to censor forbidden clones of CD4 T cells in autoimmune diabetes.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

T cell response to myelin basic protein epitopes in multiple sclerosis patients and healthy subjects

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

Modulation of Th1 activation and inflammation by the NF-kappaB repressor Foxj1

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

Aire regulates negative selection of organ-specific T cells

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

The role of autoimmunity in islet allograft destruction: major histocompatibility complex class II matching is necessary for autoimmune destruction of allogeneic islet transplants after T-cell costimulatory blockade

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

NOD mice have a generalized defect in their response to transplantation tolerance induction.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

Does T-cell tolerance require a dedicated antigen-presenting cell?

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

Evidence for a single-niche model of positive selection

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

Medullary but not cortical thymic epithelial cells present soluble antigens to helper T cells

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

Prolonged islet graft survival in NOD mice by blockade of the CD40-CD154 pathway of T-cell costimulation

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

Evidence for a primary islet autoantigen (preproinsulin 1) for insulitis and diabetes in the nonobese diabetic mouse

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

Positional cloning of the APECED gene

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

Negative selection and autoimmunity

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

CD4 T cell tolerance to nuclear proteins induced by medullary thymic epithelium

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

Selectivity of the major histocompatibility complex class II presentation pathway of cortical thymic epithelial cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

Genetic disassociation of autoimmunity and resistance to costimulation blockade-induced transplantation tolerance in nonobese diabetic mice.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

NOD congenic mice genetically protected from autoimmune diabetes remain resistant to transplantation tolerance induction

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

Type 1 diabetes and the control of dexamethazone-induced apoptosis in mice maps to the same region on chromosome 6

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

The insulin gene in diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

Relative resistance to nasally induced tolerance in non-obese diabetic mice but not other I-A(g7)-expressing mouse strains

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

Aire deficient mice develop multiple features of APECED phenotype and show altered immune response

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

Breaking self-tolerance in nonobese diabetic mice

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

Analysis of the role of variation of major histocompatibility complex class II expression on nonobese diabetic (NOD) peripheral T cell response

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

Targeted complementation of MHC class II deficiency by intrathymic delivery of recombinant adenoviruses

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

Thymic emigration: conveyor belts or lucky dips?

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

Autoreactive T and B cells responding to myelin proteolipid protein in multiple sclerosis and controls

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

Insulin-dependent diabetes mellitus

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

Selection of a broad repertoire of CD4+ T cells in H-2Ma0/0 mice

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

AIRE functions as an E3 ubiquitin ligase

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

Quantitative impact of thymic clonal deletion on the T cell repertoire

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

Good riddance: Thymocyte clonal deletion prevents autoimmunity

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

Efficient T cell receptor–mediated apoptosis in nonobese diabetic mouse thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

The genetic background of autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy and its autoimmune disease components

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

The enemy within: keeping self-reactive T cells at bay in the periphery

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

Human thymic stromal lymphopoietin promotes dendritic cell-mediated CD4+ T cell homeostatic expansion.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2804%2900111-6

7 January 2021

10.1016/S1074-7613(04)00111-6

Identifiers

DOI

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10 August 2017

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