Modulation of neurodegeneration by molecular chaperones (Q35990274)

11 August 2017

1 reference

title

Modulation of neurodegeneration by molecular chaperones (English)

1 reference

11 August 2017

0 references

1 reference

Paul J Muchowski

1

1 reference

11 August 2017

Jennifer L Wacker

series ordinal

2

1 reference

11 August 2017

language of work or name

English

0 references

publication date

1 January 2005

1 reference

Nature Reviews Neuroscience

11 August 2017

published in

1 reference

11 August 2017

volume

6

1 reference

11 August 2017

issue

1

1 reference

11 August 2017

page(s)

11-22

1 reference

Protein misfolding, amyloid formation, and neurodegeneration: a critical role for molecular chaperones?

11 August 2017

cites work

1 reference

Chaperones and aging: role in neurodegeneration and in other civilizational diseases

31 March 2020

1 reference

Principles that govern the folding of protein chains

31 March 2020

1 reference

Macromolecular crowding: an important but neglected aspect of the intracellular environment

31 March 2020

1 reference

Molecular chaperones in the cytosol: from nascent chain to folded protein

31 March 2020

1 reference

31 March 2020

The heat-shock response

1 reference

Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions

31 March 2020

1 reference

CHIP is a U-box-dependent E3 ubiquitin ligase: identification of Hsc70 as a target for ubiquitylation

31 March 2020

1 reference

The ubiquitin-related BAG-1 provides a link between the molecular chaperones Hsc70/Hsp70 and the proteasome

31 March 2020

1 reference

Lysosomes, a meeting point of proteins, chaperones, and proteases

31 March 2020

1 reference

Protein folding and misfolding

31 March 2020

1 reference

Clinical, pathological, and neurochemical changes in dementia: A subgroup with preserved mental status and numerous neocortical plaques

31 March 2020

1 reference

Some morphometric aspects of the brain in senile dementia of the alzheimer type

31 March 2020

1 reference

Neuropathological stageing of Alzheimer-related changes

31 March 2020

1 reference

Contribution of somal Lewy bodies to neuronal death

31 March 2020

1 reference

Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation

31 March 2020

1 reference

Requirement of an intact microtubule cytoskeleton for aggregation and inclusion body formation by a mutant huntingtin fragment.

31 March 2020

1 reference

Aggresomes protect cells by enhancing the degradation of toxic polyglutamine-containing protein

31 March 2020

1 reference

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

31 March 2020

1 reference

Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders

31 March 2020

1 reference

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

31 March 2020

1 reference

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

31 March 2020

1 reference

Cellular defenses against unfolded proteins: a cell biologist thinks about neurodegenerative diseases

31 March 2020

1 reference

Intranuclear ataxin1 inclusions contain both fast- and slow-exchanging components

31 March 2020

1 reference

Live-cell imaging reveals divergent intracellular dynamics of polyglutamine disease proteins and supports a sequestration model of pathogenesis.

31 March 2020

1 reference

Polyglutamine protein aggregates are dynamic

31 March 2020

1 reference

Expression of the molecular chaperone Hsp70 in detergent-resistant microdomains correlates with its membrane delivery and release

31 March 2020

1 reference

Microglial activation and amyloid-beta clearance induced by exogenous heat-shock proteins

31 March 2020

2 references

31 March 2020

inferred from DOI database lookup

7 January 2021

based on heuristic

Bip/GRP78-induced production of cytokines and uptake of amyloid-beta(1-42) peptide in microglia

1 reference

Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models

31 March 2020

1 reference

Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation.

31 March 2020

1 reference

Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain

31 March 2020

1 reference

Behavioral disturbances without amyloid deposits in mice overexpressing human amyloid precursor protein with Flemish (A692G) or Dutch (E693Q) mutation.

31 March 2020

1 reference

Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor protein

31 March 2020

1 reference

Novel beta-secretase cleavage of beta-amyloid precursor protein in the endoplasmic reticulum/intermediate compartment of NT2N cells

31 March 2020

1 reference

Alzheimer's A beta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells

31 March 2020

1 reference

Presenilin-1, Nicastrin, Amyloid Precursor Protein, and γ-Secretase Activity Are Co-localized in the Lysosomal Membrane

31 March 2020

1 reference

The chaperone BiP/GRP78 binds to amyloid precursor protein and decreases Abeta40 and Abeta42 secretion.

31 March 2020

1 reference

Heat shock protein 70 participates in the neuroprotective response to intracellularly expressed beta-amyloid in neurons.

31 March 2020

1 reference

Evolving questions and paradigm shifts in endoplasmic-reticulum-associated degradation (ERAD).

31 March 2020

1 reference

The molecular chaperone alphaB-crystallin enhances amyloid beta neurotoxicity

31 March 2020

1 reference

Binding of tau to heat shock protein 27 leads to decreased concentration of hyperphosphorylated tau and enhanced cell survival

31 March 2020

1 reference

Chaperones increase association of tau protein with microtubules

31 March 2020

1 reference

CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation

31 March 2020

1 reference

CHIP-Hsc70 Complex Ubiquitinates Phosphorylated Tau and Enhances Cell Survival

31 March 2020

1 reference

Alpha-synuclein-enhanced green fluorescent protein fusion proteins form proteasome sensitive inclusions in primary neurons

31 March 2020

1 reference

TorsinA and heat shock proteins act as molecular chaperones: suppression of alpha-synuclein aggregation

31 March 2020

1 reference

Hsp70 Reduces alpha-Synuclein Aggregation and Toxicity

31 March 2020

1 reference

Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

31 March 2020

1 reference

Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease

31 March 2020

1 reference

Pharmacological prevention of Parkinson disease in Drosophila.

31 March 2020

1 reference

Stress-inducible responses and heat shock proteins: new pharmacologic targets for cytoprotection

31 March 2020

1 reference

High threshold for induction of the stress response in motor neurons is associated with failure to activate HSF1.

31 March 2020

1 reference

The stress protein response in cultured neurons: characterization and evidence for a protective role in excitotoxicity

31 March 2020

1 reference

Localization of the heat-shock protein Hsp70 to the synapse following hyperthermic stress in the brain

31 March 2020

1 reference

Up-regulation of protein chaperones preserves viability of cells expressing toxic Cu/Zn-superoxide dismutase mutants associated with amyotrophic lateral sclerosis

31 March 2020

1 reference

Mutant Cu/Zn-superoxide dismutase proteins have altered solubility and interact with heat shock/stress proteins in models of amyotrophic lateral sclerosis

31 March 2020

1 reference

Hsp70 and Hsp40 improve neurite outgrowth and suppress intracytoplasmic aggregate formation in cultured neuronal cells expressing mutant SOD1.

31 March 2020

1 reference

Analysis of the role of heat shock protein (Hsp) molecular chaperones in polyglutamine disease

31 March 2020

1 reference

Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity

31 March 2020

1 reference

Protective effect of chaperones on polyglutamine diseases

31 March 2020

1 reference

Heat shock protein 27 prevents cellular polyglutamine toxicity and suppresses the increase of reactive oxygen species caused by huntingtin

31 March 2020

1 reference

Chaperone suppression of cellular toxicity of huntingtin is independent of polyglutamine aggregation

31 March 2020

1 reference

Aggregation of huntingtin in yeast varies with the length of the polyglutamine expansion and the expression of chaperone proteins

31 March 2020

1 reference

Huntington toxicity in yeast model depends on polyglutamine aggregation mediated by a prion-like protein Rnq1

31 March 2020

1 reference

Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils

31 March 2020

1 reference

Regulation of Aging and Age-Related Disease by DAF-16 and Heat-Shock Factor

31 March 2020

1 reference

Expanded polyglutamine protein forms nuclear inclusions and causes neural degeneration in Drosophila

31 March 2020

1 reference

Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70.

31 March 2020

1 reference

Mechanisms of chaperone suppression of polyglutamine disease: selectivity, synergy and modulation of protein solubility in Drosophila.

31 March 2020

1 reference

Disruption of Axonal Transport by Loss of Huntingtin or Expression of Pathogenic PolyQ Proteins in Drosophila

31 March 2020

1 reference

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

31 March 2020

1 reference

Overexpression of heat shock protein 70 in R6/2 Huntington's disease mice has only modest effects on disease progression

31 March 2020

1 reference

Progressive decrease in chaperone protein levels in a mouse model of Huntington's disease and induction of stress proteins as a therapeutic approach

31 March 2020

1 reference

Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice

31 March 2020

1 reference

Heat shock protein 70 chaperone overexpression ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model by reducing nuclear-localized mutant androgen receptor protein

31 March 2020

1 reference

Identification of genes that modify ataxin-1-induced neurodegeneration.

31 March 2020

1 reference

Genetic suppression of polyglutamine toxicity in Drosophila

31 March 2020

1 reference

Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein

31 March 2020

1 reference

Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation

31 March 2020

1 reference

Hsp70 and Hsp40 attenuate formation of spherical and annular polyglutamine oligomers by partitioning monomer

31 March 2020

1 reference

Cellular toxicity of polyglutamine expansion proteins: mechanism of transcription factor deactivation

31 March 2020

1 reference

Mechanism of prion propagation: amyloid growth occurs by monomer addition

31 March 2020

1 reference

The role of trehalose synthesis for the acquisition of thermotolerance in yeast. II. Physiological concentrations of trehalose increase the thermal stability of proteins in vitro

31 March 2020

1 reference

A naturally occurring protective system in urea-rich cells: mechanism of osmolyte protection of proteins against urea denaturation

31 March 2020

1 reference

Trehalose accumulates in Saccharomyces cerevisiae during exposure to agents that induce heat shock response

31 March 2020

1 reference

Multiple effects of trehalose on protein folding in vitro and in vivo

31 March 2020

1 reference

Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease

31 March 2020

1 reference

Molecular chaperones and the stress of oncogenesis

31 March 2020

1 reference

Abnormal proteins serve as eukaryotic stress signals and trigger the activation of heat shock genes

31 March 2020

1 reference

Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1

31 March 2020

1 reference

Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone

31 March 2020

1 reference

Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin

31 March 2020

1 reference

Bimoclomol, a heat shock protein co-inducer, acts by the prolonged activation of heat shock factor-1

31 March 2020

1 reference

Treatment with arimoclomol, a coinducer of heat shock proteins, delays disease progression in ALS mice

31 March 2020

1 reference

HSP104 required for induced thermotolerance

31 March 2020

1 reference

Heat-shock protein 104 expression is sufficient for thermotolerance in yeast

31 March 2020

1 reference

Hsp104 catalyzes formation and elimination of self-replicating Sup35 prion conformers

31 March 2020

1 reference

Chaperones and transcriptional regulation by nuclear receptors

31 March 2020

1 reference

The Hsp70 and Hsp60 chaperone machines

31 March 2020

1 reference

A hitchhiker's guide to the human Hsp70 family

31 March 2020

1 reference

Chaperone-mediated protein folding

31 March 2020

1 reference

The conserved G/F motif of the DnaJ chaperone is necessary for the activation of the substrate binding properties of the DnaK chaperone

31 March 2020

1 reference

Regulation of the heat-shock protein 70 reaction cycle by the mammalian DnaJ homolog, Hsp40.

31 March 2020

1 reference

Molecular chaperones in cellular protein folding

31 March 2020

1 reference

Structure, function and evolution of DnaJ: conservation and adaptation of chaperone function

31 March 2020

1 reference

Alpha-crystallin can function as a molecular chaperone

31 March 2020

1 reference

Small heat-shock proteins and their potential role in human disease

31 March 2020

1 reference

Autosomal dominant congenital cataract associated with a missense mutation in the human alpha crystallin gene CRYAA

31 March 2020

1 reference

A missense mutation in the alphaB-crystallin chaperone gene causes a desmin-related myopathy

31 March 2020

1 reference

Mutant small heat-shock protein 27 causes axonal Charcot-Marie-Tooth disease and distal hereditary motor neuropathy

31 March 2020

1 reference

Hot-spot residue in small heat-shock protein 22 causes distal motor neuropathy

31 March 2020

1 reference

Hereditary spastic paraplegia SPG13 is associated with a mutation in the gene encoding the mitochondrial chaperonin Hsp60

31 March 2020

1 reference

Roles of molecular chaperones in protein misfolding diseases

31 March 2020

1 reference

Expression of heat shock proteins in Alzheimer's disease

31 March 2020

1 reference

Alpha B crystallin and HSP28 are enhanced in the cerebral cortex of patients with Alzheimer's disease.

31 March 2020

1 reference

Expression of small heat-shock protein hsp 27 in reactive gliosis in Alzheimer disease and other types of dementia

31 March 2020

1 reference

Cross-linking of ubiquitin, HSP27, parkin, and alpha-synuclein by gamma-glutamyl-epsilon-lysine bonds in Alzheimer's neurofibrillary tangles

31 March 2020

1 reference

Histological evidence of protein aggregation in mutant SOD1 transgenic mice and in amyotrophic lateral sclerosis neural tissues

31 March 2020

1 reference

Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1.

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRN1587

1 reference

11 August 2017

1 reference