Drug resistance in epilepsy: putative neurobiologic and clinical mechanisms (Q36157234)

12 August 2017

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title

Drug resistance in epilepsy: putative neurobiologic and clinical mechanisms (English)

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12 August 2017

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Dieter Schmidt

1

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12 August 2017

Wolfgang Löscher

series ordinal

2

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12 August 2017

language of work or name

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1 June 2005

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12 August 2017

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12 August 2017

volume

46

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12 August 2017

issue

6

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12 August 2017

page(s)

858-877

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Remission of epilepsy: results from the National General Practice Study of Epilepsy.

12 August 2017

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Clinical aspects and biological bases of drug-resistant epilepsies

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Refractory epilepsy: a progressive, intractable but preventable condition?

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Current status and future directions in the pharmacotherapy of epilepsy

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Pharmacoresistance: modern concept and basic data derived from human brain tissue

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When should temporal-lobe epilepsy be treated surgically?

21 January 2018

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New horizons in the development of antiepileptic drugs: the search for new targets.

21 January 2018

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Does the cause of localisation-related epilepsy influence the response to antiepileptic drug treatment?

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Treatment outcome in patients with mesial temporal sclerosis.

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Is the underlying cause of epilepsy a major prognostic factor for recurrence?

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Antiepileptogenesis and seizure prevention trials with antiepileptic drugs: meta-analysis of controlled trials

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Effectiveness of first antiepileptic drug.

21 January 2018

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How long does it take for partial epilepsy to become intractable?

21 January 2018

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Do epileptic seizures damage the brain?

21 January 2018

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Hippocampal sclerosis is a progressive disorder: a longitudinal volumetric MRI study

21 January 2018

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Progressive neocortical damage in epilepsy

21 January 2018

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Effects of chronic epilepsy on declarative memory systems

21 January 2018

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Dose-response trial of pregabalin adjunctive therapy in patients with partial seizures

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New visions in the pharmacology of anticonvulsion

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The neurobiology of antiepileptic drugs

21 January 2018

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The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam

21 January 2018

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Effect of valproic acid on sodium currents in cortical neurons from patients with pharmaco-resistant temporal lobe epilepsy

21 January 2018

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A novel mechanism underlying drug resistance in chronic epilepsy

21 January 2018

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Anticonvulsant pharmacology of voltage-gated Na+ channels in hippocampal neurons of control and chronically epileptic rats

21 January 2018

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Molecular and functional changes in voltage-dependent Na(+) channels following pilocarpine-induced status epilepticus in rat dentate granule cells

21 January 2018

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Effects of conventional antiepileptic drugs in a model of spontaneous recurrent seizures in rats

21 January 2018

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Effects of the novel antiepileptic drug levetiracetam on spontaneous recurrent seizures in the rat pilocarpine model of temporal lobe epilepsy

21 January 2018

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Effect of phenytoin on sodium and calcium currents in hippocampal CA1 neurons of phenytoin-resistant kindled rats

21 January 2018

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Channelopathies as a genetic cause of epilepsy

21 January 2018

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Genes and mutations in human idiopathic epilepsy

21 January 2018

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A new benzodiazepine pharmacology.

21 January 2018

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Analysis of GABAA receptor function and dissection of the pharmacology of benzodiazepines and general anesthetics through mouse genetics

21 January 2018

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GABAA receptor beta 1-3 subunit gene expression in the hippocampus of kindled rats

21 January 2018

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Biphasic differential changes of GABAA receptor subunit mRNA levels in dentate gyrus granule cells following recurrent kindling-induced seizures

21 January 2018

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Selective changes in single cell GABA(A) receptor subunit expression and function in temporal lobe epilepsy

21 January 2018

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Increased number of synaptic GABA(A) receptors underlies potentiation at hippocampal inhibitory synapses.

21 January 2018

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Expression of GABA(A) receptor subunits in the hippocampus of the rat after kainic acid-induced seizures

21 January 2018

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GABAergic neurons and GABA(A)-receptors in temporal lobe epilepsy.

21 January 2018

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Dentate granule cell GABA(A) receptors in epileptic hippocampus: enhanced synaptic efficacy and altered pharmacology

21 January 2018

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Characterization of pharmacoresistance to benzodiazepines in the rat Li-pilocarpine model of status epilepticus

21 January 2018

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The anti-epileptic drug levetiracetam reverses the inhibition by negative allosteric modulators of neuronal GABA- and glycine-gated currents

21 January 2018

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ABC transporters and the blood-brain barrier

21 January 2018

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Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview.

21 January 2018

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Drug efflux transporters in the CNS.

21 January 2018

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Overexpression of multiple drug resistance genes in endothelial cells from patients with refractory epilepsy.

21 January 2018

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Expression and cellular distribution of multidrug transporter proteins in two major causes of medically intractable epilepsy: focal cortical dysplasia and glioneuronal tumors

21 January 2018

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Expression and cellular distribution of multidrug resistance-related proteins in the hippocampus of patients with mesial temporal lobe epilepsy

21 January 2018

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Induction of P-glycoprotein expression in astrocytes following intracerebroventricular kainate injections

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2005.54904.X

Transient increase of P-glycoprotein expression in endothelium and parenchyma of limbic brain regions in the kainate model of temporal lobe epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2005.54904.X

Neuronal expression of the drug efflux transporter P-glycoprotein in the rat hippocampus after limbic seizures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2005.54904.X

Increased expression of the multidrug transporter P-glycoprotein in limbic brain regions after amygdala-kindled seizures in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2005.54904.X

Pharmacoresistance and expression of multidrug transporter P-glycoprotein in kindled rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2005.54904.X

Multidrug-resistance protein 1 in focal cortical dysplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2005.54904.X

Major vault protein, a marker of drug resistance, is upregulated in refractory epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2005.54904.X

Potential role of drug transporters in the pathogenesis of medically intractable epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2005.54904.X

Role of multidrug transporters in pharmacoresistance to antiepileptic drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2005.54904.X

Vascular and Parenchymal Mechanisms in Multiple Drug Resistance: a Lesson from Human Epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2005.54904.X

Mechanisms of antiepileptic drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2005.54904.X

Blood-brain barrier active efflux transporters: ATP-binding cassette gene family

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2005.54904.X

Drug delivery via the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2005.54904.X

Significance of MDR1 and multiple drug resistance in refractory human epileptic brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2005.54904.X

In vivo evidence for P-glycoprotein-mediated transport of phenytoin at the blood-brain barrier of rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2005.54904.X

Multidrug resistance-associated protein is involved in the regulation of extracellular levels of phenytoin in the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2005.54904.X

Multidrug resistance protein MRP2 contributes to blood-brain barrier function and restricts antiepileptic drug activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2005.54904.X

P-glycoprotein and multidrug resistance-associated protein are involved in the regulation of extracellular levels of the major antiepileptic drug carbamazepine in the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2005.54904.X

P-glycoprotein-mediated efflux of antiepileptic drugs: preliminary studies in mdr1a knockout mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2005.54904.X

Distribution of valproate across the interface between blood and cerebrospinal fluid

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2005.54904.X

Expression of multidrug resistance-associated protein (MRP) in brain microvessel endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2005.54904.X

Valproic acid uptake by bovine brain microvessel endothelial cells: role of active efflux transport.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2005.54904.X

P-Glycoprotein-mediated efflux of phenobarbital, lamotrigine, and felbamate at the blood-brain barrier: evidence from microdialysis experiments in rats

21 January 2018

1 reference

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Brain access and anticonvulsant efficacy of carbamazepine, lamotrigine, and felbamate in ABCC2/MRP2-deficient TR- rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2005.54904.X

Inhibition of multidrug transporters by verapamil or probenecid does not alter blood-brain barrier penetration of levetiracetam in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2005.54904.X

The multidrug resistance protein family.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2005.54904.X

Plasma membrane localization of multidrug resistance-associated protein homologs in brain capillary endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2005.54904.X

Clinical aspects of the MDR1 (ABCB1) gene polymorphism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2005.54904.X

Pharmacogenomics of drug transporters: a new approach to functional analysis of the genetic polymorphisms of ABCB1 (P-glycoprotein/MDR1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2005.54904.X

Interaction of antiepileptic drugs with human P-glycoprotein in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2005.54904.X

Carbamazepine is not a substrate for P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2005.54904.X

Do seizures beget seizures? An assessment of the clinical evidence in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2005.54904.X

Use of verapamil as a potential P-glycoprotein inhibitor in a patient with refractory epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2005.54904.X

New horizons in the development of antiepileptic drugs

21 January 2018

1 reference

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Emergent properties of CNS neuronal networks as targets for pharmacology: application to anticonvulsant drug action

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2005.54904.X

Distribution of glutamate transporters in the hippocampus of patients with pharmaco-resistant temporal lobe epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2005.54904.X

Strategies in antiepileptic drug development: is rational drug design superior to random screening and structural variation?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2005.54904.X

PET Studies on P-glycoprotein function in the blood-brain barrier: how it affects uptake and binding of drugs within the CNS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2005.54904.X

What is the evidence that oxcarbazepine and carbamazepine are distinctly different antiepileptic drugs?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2005.54904.X

The clinical impact of new antiepileptic drugs after a decade of use in epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2005.54904.X

Is epilepsy a progressive disorder? Prospects for new therapeutic approaches in temporal-lobe epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2005.54904.X

Disease modification in partial epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2005.54904.X

New strategies for the identification of drugs to prevent the development or progression of epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2005.54904.X

Multidrug resistance transporters and modulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2005.54904.X

Association of Multidrug Resistance in Epilepsy with a Polymorphism in the Drug-Transporter GeneABCB1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2005.54904.X

Seizure-associated hippocampal volume loss: A longitudinal magnetic resonance study of temporal lobe epilepsy

21 January 2018

1 reference

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10.1111/J.1528-1167.2005.54904.X

21 January 2018

Identifiers

DOI

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12 August 2017

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